Guigen Zhang, PhD, is a professor of bioengineering and of electrical and computer engineering at Clemson University. He is the executive director of the Institute for Biological Interfaces of Engineering, a research and education/training institute designated by the South Carolina Commission on Higher Education. Prof. Zhang is also a fellow of the American Institute for Medical and Biological Engineering (AIMBE). He has published extensively in the areas of biomechanics, biomaterials, and biosensors, and he holds numerous patents in nanotechnology-enhanced structures and biosensors.

"... an excellent overview of state-of-the-art methods developed to approach complex cardiovascular problems. It provides a way to model the integrative physiology aspects of the circulatory system - an aspect necessary when dealing with "patient specific" modeling." -Lakshmi Prasad Dasi, Colorado State University "... very well written ... large range of computation modeling approaches discussed in the book and that have been developed to address a broad spectrum of problems in the field of bioengineering." -Sundar Srinivasan, University of Washington "... presents a timely and interactive compilation of work in the forefronts of computational bioengineering. ... ideal for the use in both research and training; it will benefit and bringer closer the scientific computation and bioengineering communities." -Hao Lin, Rutgers, The State University of New Jersey

• Preface 1. An Integrative Way of Solving Bioengineering Problems 2. Toward Predicting the Performance of Joint Arthroplasty 3. Mathematical Modelling of Basic Multicellular Units: The Functional Units of Bone Remodeling 4. Effect of Nonlinearity in Tensioned Wires of an External Fixation Device 5. Viscoelasticity of Load-Bearing Soft Tissues: Constitutive Formulation, Numerical Integration, and Computational Implementation 6. Physical Signals and Solute Transport in Human Intervertebral Disc: Multiphasic Mechano-Electrochemical Finite Element Analysis 7. Multiscale Modeling of Cardiovascular Flows 8. Computational Fluid Modeling of Heart Valves 9. Mathematical Modeling of Cancer Metastases 10. Dynamic Processes in Photodynamic Therapy 11. Computational Cell Phenotyping in the Lab, Plant, and Clinic 12. Molecular Simulation of Protein–Surface Interactions 13. Structure of the Electrical Double Layers: Insights from Continuum and Atomistic Simulations 14. A Solid-State Nanopore as Biosensor 15. DNA Electrokinetic Translocation through a Nanopore16. Dielectrophoresis for Bioengineering Applications and Some Associated Issues 17. Image-Based Modeling for Bioengineering Problems