Melatonin

Professor Venkataramanujam Srinivasan, PhD, MAMS, started his professional career as an assistant professor at the Institute of Physiology, Madurai Medical College, Madurai, Tamil Nadu, India, where he served for 24 years. Along with teaching physiology to undergraduate medical students, he undertook various collaborative research studies with the Department of Psychiatry and published a number of papers on lithium, catecholamine metabolism, the pineal gland, and melatonin both in national and international medical and life sciences journals. He has also served as one of the advisory council members for the International Society of Psychoneuroendocrinology (ISPNE) for ten years. Professor Srinivasan then undertook teaching assignments as associate professor of physiology at the University Sains Malaysia (USM). He has collaborated on research publications with a number of professors and research scientists working in different universities internationally. Since May 2009, he has undertaken research studies on melatonin and melatonergic drugs from Sri Sathya Sai Medical Educational and Research Foundation, an international medical sciences research study center in Kovai Thirunagar, Tamil Nadu, India and has published number of papers in indexed medical journals. He also edited a book on melatonin and melatonergic drugs in clinical practice, published by Springer in February 2014.Dr. Gabriella Gobbi is an associate professor in the Department of Psychiatry, McGill University and a staff psychiatrist at the McGill University Health Center (MUHC), Montreal, Canada. Her research interests include understanding the pathophysiology of major depression and related disorders and discovering new treatments for them. In particular, her laboratory conducts research on the short- and long-term effects of cannabis use in mood and anxiety and the potential beneficial effects of drugs acting on the endocannabinoid system (endogenous cannabis) to cure mental dise

"This is a significant contribution to the knowledge base in melatonin physiology and its therapeutic application, written by prominent experts in the field." -M. Isabel L. Crisostomo, MD, Rush University Medical Center in Doody's Book Reviews

• Melatonin Production and Bioavailability. Deviations of Melatonin Levels and Signaling in Aging and Diseases: Options and Limits of Treatment. Pineal Gland Volume and Melatonin. Melatonin’s Beneficial Effects in Metabolic Syndrome with Therapeutic Applications. Therapeutic Applications of Melatonin in Pediatrics. Neuroprotective Effect of Melatonin on Perinatal Hypoxia–Ischemia. Melatonin as a Therapeutic Agent for Sepsis. Melatonin’s Cardioprotective Role. Melatonin: Therapeutic Value and Neuroprotection in Stroke. Melatonin’s Antiapoptotic Activity in Neurodegenerative Diseases. MT2 Melatonin Receptors: Their Role in Sleep and Neuropsychiatric Disorders. Melatonin: Its Hepatoprotective Actions and the Role of Melatonin Receptors. Melatonin Signaling in the Control of Development and Replication. Melatonin: Regulator of Adult Hippocampal Neurogenesis. Comparison of Neuroprotective Effect of Melatonin in the Nigrostriatal and Mesolimbic Dopaminergic Systems of the Zitter Rat. Melatonin’s Neuroprotective Role in Parkinson’s Disease. Neuroprotective Role of Melatonin in Glaucoma. Melatonin Receptors and Their Preventive Role in Carcinogenesis. Enhancement of Antitumor Activity of Ursolic Acid by Melatonin in Colon Cancer Cells. Synthetic Melatonin Receptor Ligands. Evaluation of Synthetic Melatonin Analog Antioxidant Compounds. Melatonin’s Analogues in Glaucoma. Melatonergic Drugs as Therapeutic Agents for Insomnia and Depressive Disorders. Agomelatine: A Neuroprotective Agent with Clinical Utility beyond Depression and Anxiety. Melatonergic Antidepressant Agomelatine in Depressive and Anxiety Disorders. Effects of Melatonin and Melatonergic Drugs in Transgenic Mouse Models of Alzheimer’s Disease. Melatonin’s Mitochondrial Protective Role in Alzheimer’s Mice: Role of Melatonin Receptors. Melatonin and Its Therapeutic Implications in Injuries of the Developing Brain and Retina. Melatonin’s Protection against Human Prion-Mediated Neurotoxicity. Melatonin’s Protection