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Beskrivning
Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds.
Synthetic Chemistry and Biochemistry.- Platinum DNA Chemistry.- New Insights About the Interaction of Cisplatinum with Intracellular Components.- Modelling Platinum — DNA Interactions.- From the Modelization of DNA Platination to the Conception of New Drugs.- cis-Diammineplatinum (II) Complexes Tethered to DNA-Affinic Ligands: Antitumor Activity and DNA-binding Properties.- Complexes of Peptides and Related Molecules with Diammineplatinum (II) as Models for Platinum-Protein Interactions.- Reactivity of DNA and cis-Diamminedichloroplatinum (II) in the Presence of Intercalating Agents.- Structurally Novel Platinum Antitumor Compounds.- Synthesis and Reactions of a New Class of Orally Active Platinum (IV) Antitumor Complexes.- Pt-DNA Interactions: Oligonucleotide Models.- New Approaches to the Design of Platinum Antitumor Agents.- Developmental Approach to Prepare New Types of Antitumor Platinum Complexes with Dual Function.- Synthesis and Antitumor Activity of Some Novel Platinum(II) Organoamides and Organometallics.- Biochemical and Molecular Pharmacology.- Role of Membrane Ion Transport in Cisplatin Accumulation.- Enhancement of the Antiproliferative Effect of cis-Diamminedichloroplatinum (II) and Other Antitumor Agents by Inhibitors of Enzymes Involved in Growth Factor Signal-Transduction.- Signal Transduction Pathway Regulation of DDP Sensitivity.- The Role of Platinum-DNA Lesions in the Inhibition of DNA Replication.- Activation of a Genetic Program for Cell Death.- Molecular Aspects of Repair and Mutagenesis of cis-Platin-Induced Lesions.- Isolation of a Gene Associated with Resistance to Cisplatin.- Repair of Damaged DNA In Vitro by Extracts from Human Cell Lines.- Gene Specific Damage and Repair of Platinum Adducts and Crosslinks.- A Protein from Mammalian CellsThat Recognizes Piatinated DNA.- Sensitization of Resistant Human Tumor Cells to Cisplatin or Carboplatin by Inhibitors of DNA Excision Repair.- Carrier Ligand Effects in Platinum-resistant Cell Lines.- Immunocytochemical Analysis of Platinum-DNA Adducts.- Strategies for Increasing the Efficacy of and Overcoming Resistance to Platinum Complexes In Vivo.- The Role of c-fos Oncogenes in Cisplatin Resistance.- Metallothioneins and Cisplatin Resistance.- A New Membrane Protein Associated with Resistance to cis-Platinum and Methotrexate.- Toxicology and Clinical Pharmacology of New Drugs.- Pharmacokinetics of Carboplatin in Children and the Development of a Paediatric Dose Equation.- Clinical Studies with Cisplatin Analogues, 254-S, DWA2114R and NK121.- Clinical and Pharmacokinetic Studies on the New Platinum Complex, Zeniplatin (CL286, 558).- Oxalatoplatinum (I-OHP): Experimental and Clinical Studies.- Pharmacologic Studies with New Liposome-Entrapped Cisplatin Derivatives.- Ammine/Amine Platinum IV Dicarboxylates: A Novel Class of Complexes Which Circumvent Intrinsic Cisplatin Resistance.- Clinical Trials.- Dose Intensity Analysis May Help Resolve Issues in Chemotherapy with Platinum Compounds.- Cisplatin Dose-intensity in Testicular Cancer Treatment: Analysis of a Randomized Clinical Trial.- Phase I/II Study to Further Escalate the Dose of Carboplatin in Combination with GM-CSF in the Treatment of Refractory Ovarian Cancer.- High Dose Carboplatin with Peripheral Blood Stem Cell and Growth Factor Support.- Pharmacologic, Pre-clinical and Clinical Investigations of the Cisplatin/Taxol Combination.- Phase I Trials with Ormaplatin (Tetraplatin).- Intraperitoneal Cisplatin and Carboplatin in the Management of Ovarian Cancer.- Radiotherapy Combined with Daily or Weekly cis-Diamminedichloroplatinum (II) in Inoperable Non-metastasized Non-small Cell Lung Cancer: A Toxicity Report of the Randomized Phase III Study of the EORTC Lung Cancer Cooperative and Radiotherapy Cooperative Groups.- Optimizing Dose-Intensity: Combining Carboplatin with Cisplatin.- High Dose Cisplatin: Modulation of Toxicity.- Probenecid and Diethyldithiocarbamate as Modifiers of Cisplatin Toxicity.- ORG 2766 in the Prevention of Cisplatin Neuropathy.- WR-2721 (Ethyol): Reduction in Toxicity of Anticancer Therapy without Loss of Efficacy.- High-Dose Cisplatin with Glutathione Protection in Gynecologic Malignancies.- Improved Efficacy of “Two-route Chemotherapy” Using Cisplatin and its Antidote, Sodium Thiosulfate in Combination with Angiotensin II.
