The topics analyzed cover a broad spectrum of lipid droplets and presents new information in this area of research. The themes analyzed include: Lipid droplets as potential antiviral targets; lipid droplets during embryonic development; lipid droplets and their contribution to vldl and chylomicron maturation; important advances in the knowledge of lipid droplets in the last six decades; lipid droplets: structure, composition, formation and function, connection with the endoplasmic reticulum, signaling of lipid droplet metabolism by tor and ampk pathways; and lipid droplets and the pathophysiology of liver diseases.