Neurotransmitter Transporters

Structure, Function, and Regulation

AvMaarten E. A. Reith

Häftad, Engelska, 2010

Del i serien Contemporary Neuroscience

2 117 kr

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Beskrivning

Maarten Reith and his contributors fully update all the material in his widely acclaimed first edition, expanding it to include the important progress made in characterizing the structure, function, regulation, and physiological relevance of each transporter. The new material includes discussions of gene organization and the relationship of polymorphisms of monoamine transporters with a variety of diseases, transgenic animals carrying altered genes for plasma membrane monoamine transporters, and the regulation of transporters by trafficking in relation to their phosphorylation state. Also addressed are transporter imaging techniques that allow in vivo measurement in men and animals, chimera and site-directed mutagenesis of transporters, and transporter electrophysiology. Neurotransmitter Transporters: Structure, Function, and Regulation, Second Edition continues to be the most informative and useful review of the field, allowing comparison between the characteristics of various neurotransmitter transporters and their biological roles in such a way that progress for one transporter can help move the field of another transporter forward.

Produktinformation

Utgivningsdatum:2010-11-19
Mått:152 x 229 x 29 mm
Vikt:762 g
Format:Häftad
Språk:Engelska
Serie:Contemporary Neuroscience
Antal sidor:518
Upplaga:2
Förlag:Humana Press Inc.
ISBN:9781617372674

Utforska kategorier

Biovetenskap inom Naturvetenskap och teknik

Recensioner i media

From Reviews of the first edition... "...highly informative and useful..."-Trends in Neurosciences

Innehållsförteckning

1 • Regulation of Monoamine Transporters: Regulated Phosphorylation, Dephosphorylation, and Trafficking.- 2 • Mechanisms of Biogenic Amine Neurotransmitter Transporters.- 3 • Structure-Function Relationships for Biogenic Amine Neurotransmitter Transporters.- 4 • Gene Organization and Polymorphisms of Monoamine Transporters: Relationship to Psychiatric and Other Complex Diseases.- 5 • Monoamine Transporters: Their Role in Maintaining Neuronal Homeostasis.- 6 • Family of Sodium-Coupled Transporters for GABA, Glycine, Proline, Betaine, Taurine, and Creatine: Pharmacology, Physiology, and Regulation.- 7 • Sodium-Coupled GABA and Glutamate Transporters: Structure and Function.- 8 • The High-Affinity Glutamate and Neutral Amino-Acid Transporter Family: Structure, Function, and Physiological Relevance.- 9 • Vesicular Neurotransmitter Transporters: Pharmacology, Biochemistry, and Molecular Analysis.- 10 • Neurotransmitter-Transporter Proteins: Post-Translational Modifications.- 11 • Dopamine-Transporter Uptake Blockers: Structure-Activity Relationships.- 12 • Imaging the Brain Dopamine Transporter Using PET and SPECT.- 13 • In Vitro and In Vivo Imaging of the Human Dopamine Transporter in Cocaine Abusers.