Carbohydrate Chemistry

Dr Yves Queneau, Research Director at CNRS, is Head of the Organic and Bioorganic Chemistry Laboratory at INSA Lyon, Deputy-Director of the “Institut de Chimie et Biochimie Moléculaires et Supramoléculaires” (ICBMS), University of Lyon, France and Honorary Professor at the University of Hull, UK. After his doctorate on aqueous Diels-Alder reactions involving glycodienes under the supervision of Professor André Lubineau (Orsay, 1988) he was appointed as CNRS fellow and worked on cycloaddition reactions towards complex sugars. He then spent one year in 1992 in Professor Samuel J. Danishefsky’s group in Memorial Sloan Kettering Cancer Center in New York, USA. He later moved to Lyon in a mixed CNRS-industrial research facility dedicated to sucrose chemistry (1995-2003) before joining its present position where he develops his research in organic and biological chemistry with a particular interest for the use of carbohydrates as renewable raw materials.

• N-Glycans as fundamental immune-checkpoints at the frontiers of inflammation, autoimmunity and cancerKeeping an eye on the sialyl-Tn targetExploring the complex role of protein glycosylation in the pathogenesis of Parkinson’s diseaseGlycosyltransferases in tumour-associated O-glycan biosynthesis: structural features and molecular recognitionMycobacterial pathways from simple glycosides to fatty acid-sheltering polymethylated polysaccharidesExploring the three-dimensional structures of LytR-CpsA-Psr proteins: implications for the maturation of the peptidoglycanSustainable synthesis of value-added compounds from carbohydrates and carbohydrate-based platform moleculesEmergent chemical and glycoengineering approaches for accessing the cancer glycoproteomeOverview of glycans in disease: plant lectins as sensitive tools to decode glycosylation changes