Metabolic Interaction in Infection

Ricardo Silvestre is Principal Investigator at the Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Portugal. His research interest is to integrate the study of basic molecular and cellular mechanisms to develop a greater understanding of the immune-metabolic interface in innate immune cells. He addresses how the modifications of host cell metabolism and bioenergetics arising during inflammatory or infectious processes impact the immune functions of monocytes/macrophage and dendritic cells and the further consequences to tissue homeostasis with the objective of developing new approaches to prevention and treatment. Egídio Torrado is Assistant Researcher at the Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Portugal. His research is focused on the mechanisms that regulate the protective immune response to Mycobacterium tuberculosisboth during the innate and chronic phases of the infection. The emphasis of his work is on cytokines and the maintenance of the T cell response and the development of pathological consequences to the host.

• Part I: A guide of metabolism during host-pathogen interactions.- 1. Cellular metabolism at a glance.- 2. Interaction between nutrition and metabolism.- 3. Interplay between metabolic sensors and cell signaling.- 4. Alterations on cellular redox states upon infection and implications for host cell homeostasis.- 5. Mitochondrial bioenergetics and dynamics during infection.- 6. Computational systems biology of metabolism in infection.- 7. Metabolomic-based methods in diagnosis and monitoring infection progression.- Part II: Microbial metabolic adaptation and pathogen rewiring of host cell metabolism during infection.- 8. Metabolic host response to intracellular infections.- 9. Protozoan parasites auxotrophies and metabolic dependencies.- 10. Viral manipulation of the host metabolic network.- 11. Metabolic regulation of innate immunity to fungal infection.- 12. Metabolic crosstalk between host and parasitic pathogens.- 13. Microbiome and gut dysbiosis.