Calcitonin Gene-Related Peptide (CGRP) Mechanisms

Focus on Migraine

AvSusan D. Brain,Pierangelo Geppetti

Häftad, Engelska, 2020

Del 255 i serien Handbook of Experimental Pharmacology

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Beskrivning

Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.

Produktinformation

Utgivningsdatum:2020-09-11
Mått:155 x 235 x 12 mm
Vikt:312 g
Format:Häftad
Språk:Engelska
Serie:Handbook of Experimental Pharmacology
Antal sidor:192
Förlag:Springer Nature Switzerland AG
ISBN:9783030214562

Utforska kategorier

Farmakologi inom Medicin
Smärta och smärtbehandling inom Medicin
Biovetenskap inom Naturvetenskap och teknik

Innehållsförteckning

1. CGRP Discovery and Timeline.- 2. CGRP Receptor Biology: Is There More Than One Receptor?.- 3. The Structure of the CGRP and Related Receptors.- 4. CGRP Receptor Signalling Pathways.- 5. Pathways of CGRP Release from Primary Sensory Neurons.- 6. CGRP in Animal Models of Migraine.- 7. CGRP in Human Models of Migraine.- 8. Role of CGRP in Migraine.- 9. Understanding CGRP and Cardiovascular Risk.- 10. CGRP and Painful Pathologies other than Headache.- 11. Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies.