Prof. Dr. Alexzander A. A. Asea is a highly innovative and accomplished world renowned clinical and basic research scientist and visionary executive leader who has exceptional experience spearheading clinical and basic science research, training, education, and commercialization initiatives within top ranked academic biomedical institutes. Prof. Dr. Asea’s initial findings studying the effects of Hsp72 on human monocytes lead to the proposal of a novel paradigm that Hsp72, previously known to be an intracellular molecular chaperones, can be found in the extracellular milieu where it has regulatory effects on immuno-competent cells - a term now called chaperokine. Prof. Asea has authored over 255 scientific publications including peer-reviewed articles, reviews, books, book chapters, editorials, and news headliners in a wide range of biomedical-related disciplines. Prof. Asea is the series editor of the widely successful book series Heat Shock Proteins (Springer Nature Publishing) and is an editorial board member of numerous scientific peer-reviewed journals. Currently, Prof. Dr. Asea is at the University of Toledo College of Medicine and Life Sciences in Toledo, USA.Dr. Punit Kaur is an expert in onco-proteogenomics, with extensive training and experience in quantitative mass spectrometry imaging, protein chemistry and biomarker discovery. Dr. Kaur’s main research focus is on the use of heat-induced nanotechnology in combination with radiotherapy and chemotherapy in the cancer stem cell therapy. Dr. Kaur has published more than 40 scientific articles, book chapters, and reviews, and currently serves as editorial board member for the European Journal of Cancer Prevention and the Journal of Proteomics and Bioinformatics. Dr. Kaur is an editor of 9 books in the highly successful Heat Shock Proteins book series by Springer Nature Publishers. Currently, Dr. Kaur is a Visiting Scientist Professor at the University of Texas MD Anderson Cancer Center in Houston, USA.

• Section I: Neurological Aspects of HSP.- Chapter 1. Hsp60 Friend and Foe of the Nervous System.- Chapter 2. Role of Heat Shock Proteins in Brain Tumors.- Chapter 3. Body Temperature Regulation Determines Immune Reactions and Species Longevity.- Chapter 4. Interaction between Heat Shock Proteins and Components of the Plasminogen Activator System in the Central Nervous System.- Chapter 5. Role of HSP70 in Plasticity and Mem.- Chapter 6. Role of Heat Shock Proteins (HSP) in Neuroprotection for Ischemic Stroke.- Section II: Aspects of HSP in Neurodegenerative Diseases and Disorders.- Chapter 7. Dysregulation of Heat Shock Proteins in Neurodegenerative Diseases: Restorative Roles of Small Molecules and Natural Compounds.- Chapter 8. Molecular Chaperones and Protein Quality Control System in the Canine Model of Brain Aging and Neurodegenerative Diseases.- Chapter 9. Role of Hsp90 Interacting Molecular Chaperones on Tau And Aß Processing in Alzheimer’s Disease.- Section III: Aspects of HSP in Multiple Sclerosis.- Chapter 10. Role of Hsp70 in Multiple Sclerosis: An Overview.- Chapter 11. Protective Role of Glial Heat Shock Proteins in Amyotrophic Lateral Sclerosis.- Section IV: Development of HSP-Based Therapies for Neurological Disorders.- Chapter 12. Therapeutic Drugs and Natural Products: The Effect of Suppressing Hsps in Brain Tumors.- Chapter 13. Can HSP Targeted Gene Therapy be a New Hope for Gliomas?.- Chapter 14. Therapeutic Aspects of Heat Shock Proteins in Glioma: Cementing the Crevasses between Bench and Bedside.- Chapter 15. Engineering Chaperones for Alzheimer’s Disease: Insights from Drosophila Models.- Chapter 16. Role of HSP in the Treatment of Internal Dıseases.

Prof. Dr. Alexzander A. A. Asea is a highly innovative and accomplished world renowned clinical and basic research scientist and visionary executive leader who has exceptional experience spearheading clinical and basic science research, training, education, and commercialization initiatives within top ranked academic biomedical institutes. Prof. Dr. Asea’s initial findings studying the effects of Hsp72 on human monocytes lead to the proposal of a novel paradigm that Hsp72, previously known to be an intracellular molecular chaperones, can be found in the extracellular milieu where it has regulatory effects on immuno-competent cells - a term now called chaperokine. Prof. Asea has authored over 255 scientific publications including peer-reviewed articles, reviews, books, book chapters, editorials, and news headliners in a wide range of biomedical-related disciplines. Prof. Asea is the series editor of the widely successful book series Heat Shock Proteins (Springer Nature Publishing) and is an editorial board member of numerous scientific peer-reviewed journals. Currently, Prof. Dr. Asea is at the University of Toledo College of Medicine and Life Sciences in Toledo, USA.Dr. Punit Kaur is an expert in onco-proteogenomics, with extensive training and experience in quantitative mass spectrometry imaging, protein chemistry and biomarker discovery. Dr. Kaur’s main research focus is on the use of heat-induced nanotechnology in combination with radiotherapy and chemotherapy in the cancer stem cell therapy. Dr. Kaur has published more than 40 scientific articles, book chapters, and reviews, and currently serves as editorial board member for the European Journal of Cancer Prevention and the Journal of Proteomics and Bioinformatics. Dr. Kaur is an editor of 9 books in the highly successful Heat Shock Proteins book series by Springer Nature Publishers. Currently, Dr. Kaur is a Visiting Scientist Professor at the University of Texas MD Anderson Cancer Center in Houston, USA.

• Section I: Neurological Aspects of HSP.- Chapter 1. Hsp60 Friend and Foe of the Nervous System.- Chapter 2. Role of Heat Shock Proteins in Brain Tumors.- Chapter 3. Body Temperature Regulation Determines Immune Reactions and Species Longevity.- Chapter 4. Interaction between Heat Shock Proteins and Components of the Plasminogen Activator System in the Central Nervous System.- Chapter 5. Role of HSP70 in Plasticity and Mem.- Chapter 6. Role of Heat Shock Proteins (HSP) in Neuroprotection for Ischemic Stroke.- Section II: Aspects of HSP in Neurodegenerative Diseases and Disorders.- Chapter 7. Dysregulation of Heat Shock Proteins in Neurodegenerative Diseases: Restorative Roles of Small Molecules and Natural Compounds.- Chapter 8. Molecular Chaperones and Protein Quality Control System in the Canine Model of Brain Aging and Neurodegenerative Diseases.- Chapter 9. Role of Hsp90 Interacting Molecular Chaperones on Tau And Aß Processing in Alzheimer’s Disease.- Section III: Aspects of HSP in Multiple Sclerosis.- Chapter 10. Role of Hsp70 in Multiple Sclerosis: An Overview.- Chapter 11. Protective Role of Glial Heat Shock Proteins in Amyotrophic Lateral Sclerosis.- Section IV: Development of HSP-Based Therapies for Neurological Disorders.- Chapter 12. Therapeutic Drugs and Natural Products: The Effect of Suppressing Hsps in Brain Tumors.- Chapter 13. Can HSP Targeted Gene Therapy be a New Hope for Gliomas?.- Chapter 14. Therapeutic Aspects of Heat Shock Proteins in Glioma: Cementing the Crevasses between Bench and Bedside.- Chapter 15. Engineering Chaperones for Alzheimer’s Disease: Insights from Drosophila Models.- Chapter 16. Role of HSP in the Treatment of Internal Dıseases.

Prof. Dr. Alexzander A. A. Asea is a highly innovative and accomplished world renowned clinical and basic research scientist and visionary executive leader who has exceptional experience spearheading clinical and basic science research, training, education, and commercialization initiatives within top ranked academic biomedical institutes. Prof. Dr. Asea’s initial findings studying the effects of Hsp72 on human monocytes lead to the proposal of a novel paradigm that Hsp72, previously known to be an intracellular molecular chaperones, can be found in the extracellular milieu where it has regulatory effects on immuno-competent cells - a term now called chaperokine. Prof. Asea has authored over 255 scientific publications including peer-reviewed articles, reviews, books, book chapters, editorials, and news headliners in a wide range of biomedical-related disciplines. Prof. Asea is the series editor of the widely successful book series Heat Shock Proteins (Springer Nature Publishing) and is an editorial board member of numerous scientific peer-reviewed journals. Currently, Prof. Dr. Asea is at the University of Toledo College of Medicine and Life Sciences in Toledo, USA.Dr. Punit Kaur is an expert in onco-proteogenomics, with extensive training and experience in quantitative mass spectrometry imaging, protein chemistry and biomarker discovery. Dr. Kaur’s main research focus is on the use of heat-induced nanotechnology in combination with radiotherapy and chemotherapy in the cancer stem cell therapy. Dr. Kaur has published more than 40 scientific articles, book chapters, and reviews, and currently serves as editorial board member for the European Journal of Cancer Prevention and the Journal of Proteomics and Bioinformatics. Dr. Kaur is an editor of 9 books in the highly successful Heat Shock Proteins book series by Springer Nature Publishers. Currently, Dr. Kaur is a Visiting Scientist Professor at the University of Texas MD Anderson Cancer Center in Houston, USA.

• Section I: Neurological Aspects of HSP.- Chapter 1. Hsp60 Friend and Foe of the Nervous System.- Chapter 2. Role of Heat Shock Proteins in Brain Tumors.- Chapter 3. Body Temperature Regulation Determines Immune Reactions and Species Longevity.- Chapter 4. Interaction between Heat Shock Proteins and Components of the Plasminogen Activator System in the Central Nervous System.- Chapter 5. Role of HSP70 in Plasticity and Mem.- Chapter 6. Role of Heat Shock Proteins (HSP) in Neuroprotection for Ischemic Stroke.- Section II: Aspects of HSP in Neurodegenerative Diseases and Disorders.- Chapter 7. Dysregulation of Heat Shock Proteins in Neurodegenerative Diseases: Restorative Roles of Small Molecules and Natural Compounds.- Chapter 8. Molecular Chaperones and Protein Quality Control System in the Canine Model of Brain Aging and Neurodegenerative Diseases.- Chapter 9. Role of Hsp90 Interacting Molecular Chaperones on Tau And Aß Processing in Alzheimer’s Disease.- Section III: Aspects of HSP in Multiple Sclerosis.- Chapter 10. Role of Hsp70 in Multiple Sclerosis: An Overview.- Chapter 11. Protective Role of Glial Heat Shock Proteins in Amyotrophic Lateral Sclerosis.- Section IV: Development of HSP-Based Therapies for Neurological Disorders.- Chapter 12. Therapeutic Drugs and Natural Products: The Effect of Suppressing Hsps in Brain Tumors.- Chapter 13. Can HSP Targeted Gene Therapy be a New Hope for Gliomas?.- Chapter 14. Therapeutic Aspects of Heat Shock Proteins in Glioma: Cementing the Crevasses between Bench and Bedside.- Chapter 15. Engineering Chaperones for Alzheimer’s Disease: Insights from Drosophila Models.- Chapter 16. Role of HSP in the Treatment of Internal Dıseases.