Maryam Yavari, M.D., Ph.D., N.D. is a medical graduate of Isfahan University of Medical Sciences. She has been a research scholar at Duke University Clinical Research Institute. She then pursued a Ph.D. degree in traditional humoral (Persian) medicine at Shahid Beheshti University of Medical Sciences and worked as an assistant professor at Isfahan University of Medical Sciences. She received a naturopathic medicine doctorate (N.D.) from the Canadian College of Naturopathic Medicine (CCNM) and is currently working as a resident and clinic supervisor at CCNM. She has been active in medical education, research and development for her entire career. Her passion for evidence-based practice, holistic integrative medicine, medical education and research contributed to holding and instructing more than 40 academic courses and workshops and directing or mentoring several research projects. She has authored or coauthored over 50 peer-reviewed articles, 7 scientific books and has received 17 awards and grants in her endeavours in science and clinical practice.

• 1 Introduction: Hot and Cold Theory, the Path Towards Personalized Medicine.- Part I Definitions and Beliefs .- 2 Principle of Hot and Cold and Its Clinical Application in Traditional Chinese Medicine.- 3 Principle of Hot and Cold and Its Clinical Application  in Persian Medicine.- 4 Principle of Hot (Ushna) and Cold (Sheeta) and Its Clinical Application in Ayurvedic Medicine.- 5 Principle of Hot and Cold and Its Clinical Application in Latin American and Caribbean Medicines.- Part II Scientific Evidence.- 6 Hot and Cold Theory: Evidence in Nutrition.- 7 Hot and Cold Theory: Evidence in Pharmacology.- 8 Hot and Cold Theory: Evidence in Physiology.- 9 Hot and Cold Theory: Evidence in Systems Biology.- Part III Perspective .- 10 Hot and Cold Theory: A Personalized Medicine Approach.- 11 Hot and Cold Theory: Future Perspective.

Maryam Yavari, M.D., Ph.D., N.D. is a medical graduate of Isfahan University of Medical Sciences. She has been a research scholar at Duke University Clinical Research Institute. She then pursued a Ph.D. degree in traditional humoral (Persian) medicine at Shahid Beheshti University of Medical Sciences and worked as an assistant professor at Isfahan University of Medical Sciences. She received a naturopathic medicine doctorate (N.D.) from the Canadian College of Naturopathic Medicine (CCNM) and is currently working as a resident and clinic supervisor at CCNM. She has been active in medical education, research and development for her entire career. Her passion for evidence-based practice, holistic integrative medicine, medical education and research contributed to holding and instructing more than 40 academic courses and workshops and directing or mentoring several research projects. She has authored or coauthored over 50 peer-reviewed articles, 7 scientific books and has received 17 awards and grants in her endeavours in science and clinical practice.

• 1 Introduction: Hot and Cold Theory, the Path Towards Personalized Medicine.- Part I Definitions and Beliefs .- 2 Principle of Hot and Cold and Its Clinical Application in Traditional Chinese Medicine.- 3 Principle of Hot and Cold and Its Clinical Application  in Persian Medicine.- 4 Principle of Hot (Ushna) and Cold (Sheeta) and Its Clinical Application in Ayurvedic Medicine.- 5 Principle of Hot and Cold and Its Clinical Application in Latin American and Caribbean Medicines.- Part II Scientific Evidence.- 6 Hot and Cold Theory: Evidence in Nutrition.- 7 Hot and Cold Theory: Evidence in Pharmacology.- 8 Hot and Cold Theory: Evidence in Physiology.- 9 Hot and Cold Theory: Evidence in Systems Biology.- Part III Perspective .- 10 Hot and Cold Theory: A Personalized Medicine Approach.- 11 Hot and Cold Theory: Future Perspective.

Maryam Yavari, M.D., Ph.D., N.D. is a medical graduate of Isfahan University of Medical Sciences. She has been a research scholar at Duke University Clinical Research Institute. She then pursued a Ph.D. degree in traditional humoral (Persian) medicine at Shahid Beheshti University of Medical Sciences and worked as an assistant professor at Isfahan University of Medical Sciences. She received a naturopathic medicine doctorate (N.D.) from the Canadian College of Naturopathic Medicine (CCNM) and is currently working as a resident and clinic supervisor at CCNM. She has been active in medical education, research and development for her entire career. Her passion for evidence-based practice, holistic integrative medicine, medical education and research contributed to holding and instructing more than 40 academic courses and workshops and directing or mentoring several research projects. She has authored or coauthored over 50 peer-reviewed articles, 7 scientific books and has received 17 awards and grants in her endeavours in science and clinical practice.

• 1 Introduction: Hot and Cold Theory, the Path Towards Personalized Medicine.- Part I Definitions and Beliefs .- 2 Principle of Hot and Cold and Its Clinical Application in Traditional Chinese Medicine.- 3 Principle of Hot and Cold and Its Clinical Application  in Persian Medicine.- 4 Principle of Hot (Ushna) and Cold (Sheeta) and Its Clinical Application in Ayurvedic Medicine.- 5 Principle of Hot and Cold and Its Clinical Application in Latin American and Caribbean Medicines.- Part II Scientific Evidence.- 6 Hot and Cold Theory: Evidence in Nutrition.- 7 Hot and Cold Theory: Evidence in Pharmacology.- 8 Hot and Cold Theory: Evidence in Physiology.- 9 Hot and Cold Theory: Evidence in Systems Biology.- Part III Perspective .- 10 Hot and Cold Theory: A Personalized Medicine Approach.- 11 Hot and Cold Theory: Future Perspective.