This book constitutes the refereed proceedings of the 13th PLAIS EuroSymposium 2021 which was held in Sopot, Poland, on September 23, 2021.The objective of the PLAIS EuroSymposium 2021 is to promote and develop high quality research on all issues related to digital transformation. It provides a forum for IS researchers and practitioners in Europe and beyond to interact, collaborate, and develop this field.The 10 papers presented in this volume were carefully reviewed and selected from 34 submissions. They were organized in topical sections named: digital enterprises; smart cities; digital education; and innovative methods in data and process analysis.