Molecular Imaging in Oncology - Volume 1

Otmar Schober was Director of the Department of Nuclear Medicine at the University of Münster from 1988 to 2013 and Deputy Rector of the university from 1994 to 1998. He has extensive expertise in the natural sciences and clinical medicine and has focused on imaging methods and their implementation in preclinical and clinical applications. Professor Schober completed his studies in laser physics with Herbert Welling and in surface physics with Nobel Laureate Gerhard Ertl at the Universities of Hanover and Munich. He received his medical training in Frankfurt, Hanover, and London; Heinz Hundeshagen was his mentor. From 1995 to 2003, he was a German Research Foundation expert reviewer for Radiology, Nuclear Medicine, and Radiation Biology. He has served as Editor-in-Chief of the Journal Nuklearmedizin (2001–2011) and as a coeditor of various international journals. Professor Schober served as coordinator of the Collaborative Research Center on Molecular Cardiovascular Imaging from 1999 to 2013. As a founder of the European Institute for Molecular Imaging, he was the principal investigator at the Cluster of Excellence “Cells in Motion.”Fabian Kiessling leads the Institute for Experimental Molecular Imaging at the RWTH University in Aachen, where he is working to develop novel diagnostic and theranostic concepts, probes, and technologies. Professor Kiessling studied medicine at Heidelberg University and subsequently worked as a resident at the Department of Radiology, German Cancer Research Center (until the end of 2002). In 2003, he moved to the Department of Medical Physics in Radiology as leader of a Molecular Imaging Group. At the same time, he pursued his clinical training, becoming a board-certified radiologist in 2007. He is the author of more than 500 publications and book chapters and has been an editorial board member for various journals, including Radiology, European Radiology, Molecular Imaging and Biology, and npj Imaging. From 2019-2025 he was featured as Highly Cited Researcher by Clarivate Analytics and he has won a number of awards, including the Emil Salzer Prize for Cancer Research and the Richtzenhain Prize. He is a fellow of the World Molecular Imaging Society, served as president of the European Society for Molecular Imaging and is a member of the Academia Europaea and the German Academy of Science and Engineering (acatech). Furthermore, he co-founded the in vivo Contrast GmbH and the SonoMAC GmbH, which both distribute diagnostic probes for preclinical imaging. Jürgen Debus is a medical doctor and holds a PhD in physics. Since 2003 he is full professor and chairman of the department of Radiation Oncology at the Heidelberg University Hospital. In July 2024 he became chief medical director and chairman of the management board of Heidelberg University Hospital. Prof. Debus did pioneering work in modern conformal high precision radiotherapy and significantly contributed to development of IMRT, stereotactic irradiation techniques and particle therapy as director of the department Radiation Oncology of the DKFZ (German Cancer Center). In co-operation with Gesellschaft für Schwerionenforschung (GSI) he introduced carbon ion therapy in Germany that led to the foundation of the Heidelberg Ion beam Therapy center (HIT) in 2009. Since then, he is medical and executive director of the HIT.The scientific activities of Prof. Debus are focused on the optimization and individualization of radiation therapy, especially research and development of ion beam therapy and image guided adaptive radiotherapy with photons and ions.

• Part 1: Technology and Probe Design 1 Advanced X-ray Imaging Technology.- 2 Computed Tomography and Magnetic Resonance Imaging.- 3 (Hybrid) SPECT and PET Technologies.- 4 Total Body PET.- 5 Ultrasound Imaging.- 6 Optical and Optoacoustic Imaging.- 7 Multifunctional Magnetic Resonance Imaging Probes.- 8 Single Photon Emission Computed Tomography Tracer.- 9 F-Labeled Small-Molecule and Low-Molecular-Weight PET Tracers for the Noninvasive Detection of Cancer.- 10 Microbubble Contrast Agents for Molecular Ultrasound Imaging of Tumor Vasculature.- 11 Optical and Optoacoustic Imaging Probes.- 12 Artificial Intelligence and Radiomics in Molecular Oncology Imaging.- Part 2: Preclinical Studies 13 Pre-Clinical SPECT and SPECT-CT in Oncology.- 14 Preclinical Applications of Magnetic Resonance Imaging in Oncology.- 15 Optical and photoacoustic imaging.- 16 Preclinical PET, PET/CT and PET/MRI.- 17 Molecular Ultrasound Imaging.- 18 Advanced Microscopy Techniques.- Part 3: Clinical Applications 19 Quantitative SPECT/CT - Technique and Clinical Applications.- 20 Fluorescence Imaging of Cancer.- 21 FDG PET Hybrid Imaging.- 22 Non-FDG PET/CT.- 23 Clinical MR biomarkers.- 24 Potential clinical applications of hyperpolarized 13C and 2H MRI.- 25 Clinical PET/MR.- 26 Clinical Applications of Advanced Ultrasound Imaging.- 27 Image-Guided Radiooncology: The Potential of Artificial Intelligence in Clinical Application.- 28 Non-invasive Imaging Techniques: From Histology to In Vivo Imaging.- 29 Image-guided brain tumor surgery.- 30 Imaging Immunotherapy.- 31 Advancements in Intraoperative Imaging for Enhanced Surgical Precision.- Part 4: Image Guided Radiooncology 32 Molecular Imaging in Photon Radiotherapy.- 33 The Role of Molecular Imaging in Ion Beam Therapy.- 34 Internal Radiation Therapy.- 35 Clinical Applications of Theranostics.- Part 5: Future Challenges 36 Future Challenges of Molecular Imaging in Oncology.