Recent Results in Cancer Research – serie

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272 produkter

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272 produkter

Del 213 - Recent Results in Cancer Research
Regulatory and Economic Aspects in Oncology
AvEvelyn Walter
Inbunden, Engelska, 2019
1 363 kr
Skickas inom 10-15 vardagar
This book explores topics of importance to all who have an interest in economic methods for assessment of the efficacy and effectiveness of new cancer treatments and in regulatory measures relating to their marketing authorization and pricing. Targeted therapies and modern immunotherapy are placing a substantial strain on health care budgets. Regulation and economic methods to assess the parameters for establishing efficacy and effectiveness are therefore of prime importance. Payer authorities have to determine whether the use of these novel therapies yields clinical benefits that justify their increasing cost. In the simplest terms, cost-effectiveness analyses quantify the ratio between the extent to which an intervention raises healthcare costs and the extent to which it improves health outcomes. Rigorous cost-effectiveness analyses translate all health outcomes into quality-adjusted life years. On the other hand, in order to sustain innovation, price regulations must be coupled with efforts to ensure that drug companies are still able to recoup their investments in high-risk and high-costs research programs. Ultimately, decisions regarding health care expenditures are also a question of society’s willingness to pay.
Del 212 - Recent Results in Cancer Research
Small Molecules in Hematology
AvUwe M. Martens
Häftad, Engelska, 2019
968 kr
Skickas inom 10-15 vardagar
This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title.
Del 211 - Recent Results in Cancer Research
Small Molecules in Oncology
AvUwe M. Martens
Häftad, Engelska, 2019
1 363 kr
Skickas inom 10-15 vardagar
This book, written by respected experts, discusses in detail the latest developments in targeted oncology therapy using small molecules. It covers a wide range of small molecules, including tyrosine kinase inhibitors, mTOR, MEK, PARP, and multikinase inhibitors, as well as cell cycle and NTRK interacting agents. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book is the third edition of Small Molecules in Oncology, but has now been divided into two volumes, with the other volume focusing specifically on small molecules in hematology.
Del 214 - Recent Results in Cancer Research
Current Immunotherapeutic Strategies in Cancer
AvMatthias Theobald
Inbunden, Engelska, 2019
1 363 kr
Skickas inom 10-15 vardagar
This book offers a comprehensive review of recent advances in cancer immunotherapy, and explores the value and limitations of the most effective current therapeutic strategies and emerging treatment modalities. It discusses in detail the successes achieved using monoclonal antibodies (mAbs), including developments with regard to conjugated mAbs and also bispecific mAbs as novel treatment options for leukemia and solid tumors. It also examines the advances toward personalized immunotherapy, focusing on the effectiveness of adoptive cell therapy using genetically engineered T cells with tumor-associated antigen-specific T-cell receptors and chimeric antigen receptors, as well as the role of tailored vaccines based on the patient’s cancer mutanome. Further, it describes the impressive therapeutic results recently achieved with checkpoint inhibitors, and analyzes novel strategies to modulate the immunosuppressive tumor microenvironment. Written by leading international experts and providing up-to-date information on emerging strategies, such as oncolytic virus-based therapy, epigenetic therapy, and combination therapy, the book appeals to all those with an interest in immunotherapy as it comes of age.
Del 214 - Recent Results in Cancer Research
Current Immunotherapeutic Strategies in Cancer
AvMatthias Theobald
Häftad, Engelska, 2020
968 kr
Skickas inom 10-15 vardagar
This book offers a comprehensive review of recent advances in cancer immunotherapy, and explores the value and limitations of the most effective current therapeutic strategies and emerging treatment modalities. It discusses in detail the successes achieved using monoclonal antibodies (mAbs), including developments with regard to conjugated mAbs and also bispecific mAbs as novel treatment options for leukemia and solid tumors. It also examines the advances toward personalized immunotherapy, focusing on the effectiveness of adoptive cell therapy using genetically engineered T cells with tumor-associated antigen-specific T-cell receptors and chimeric antigen receptors, as well as the role of tailored vaccines based on the patient’s cancer mutanome. Further, it describes the impressive therapeutic results recently achieved with checkpoint inhibitors, and analyzes novel strategies to modulate the immunosuppressive tumor microenvironment. Written by leading international experts and providing up-to-date information on emerging strategies, such as oncolytic virus-based therapy, epigenetic therapy, and combination therapy, the book appeals to all those with an interest in immunotherapy as it comes of age.
Del 215 - Recent Results in Cancer Research
Tumor Liquid Biopsies
AvFlorence Schaffner,Jean-Louis Merlinm. fl.
Inbunden, Engelska, 2019
911 kr
Skickas inom 10-15 vardagar
This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.
Del 215 - Recent Results in Cancer Research
Tumor Liquid Biopsies
AvFlorence Schaffner,Jean-Louis Merlinm. fl.
Häftad, Engelska, 2020
651 kr
Skickas inom 10-15 vardagar
This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.
Molecular Imaging in Oncology
AvOtmar Schober,Fabian Kiesslingm. fl.
Inbunden, Engelska, 2020
1 741 kr
Skickas inom 11-20 vardagar
This book discusses the most significant recent advances in oncological molecular imaging, covering the full spectrum from basic and preclinical research to clinical practice. The content is divided into five sections, the first of which is devoted to standardized and emerging technologies and probe designs for different modalities, such as PET, SPECT, optical and optoacoustic imaging, ultrasound, CT, and MRI. The second section focuses on multiscale preclinical applications ranging from advanced microscopy and mass spectroscopy to whole-body imaging. In the third section, various clinical applications are presented, including image-guided surgery and the radiomic analysis of multiple imaging features. The final two sections are dedicated to the emerging, crucial role that molecular imaging can play in the planning and monitoring of external and internal radiotherapy, and to future challenges and prospects in multimodality imaging. Given its scope, the handbook will benefit allreaders who are interested in the revolution in diagnostic and therapeutic oncology that is now being brought about by molecular imaging.
Molecular Imaging in Oncology
AvOtmar Schober,Fabian Kiesslingm. fl.
Häftad, Engelska, 2021
1 341 kr
Skickas inom 11-20 vardagar
This book discusses the most significant recent advances in oncological molecular imaging, covering the full spectrum from basic and preclinical research to clinical practice. The content is divided into five sections, the first of which is devoted to standardized and emerging technologies and probe designs for different modalities, such as PET, SPECT, optical and optoacoustic imaging, ultrasound, CT, and MRI. The second section focuses on multiscale preclinical applications ranging from advanced microscopy and mass spectroscopy to whole-body imaging. In the third section, various clinical applications are presented, including image-guided surgery and the radiomic analysis of multiple imaging features. The final two sections are dedicated to the emerging, crucial role that molecular imaging can play in the planning and monitoring of external and internal radiotherapy, and to future challenges and prospects in multimodality imaging. Given its scope, the handbook will benefit allreaders who are interested in the revolution in diagnostic and therapeutic oncology that is now being brought about by molecular imaging.
Del 217 - Recent Results in Cancer Research
Viruses and Human Cancer
From Basic Science to Clinical Prevention
AvT.-C. Wu,Mei-Hwei Changm. fl.
Inbunden, Engelska, 2020
1 702 kr
Skickas inom 10-15 vardagar
This book, in a new, extensively updated edition, covers viral infection, virus-induced inflammation and tissue injuries, viral epidemiology, oncogenic mechanisms, and current and emerging preventive and therapeutic strategies in detail. Readers will also find information on the individual aspects of a number of oncogenic viruses, including hepatitis B, hepatitis C, human papillomavirus, Epstein–Barr virus, human T-cell lymphotropic virus, Kaposi sarcoma-associated herpes, and Merkel cell polyomavirus, as well as associated human cancers. The book will benefit all those who are seeking a comprehensive, up-to-date overview of the basic and clinical aspects of oncogenic viruses and associated human cancers. Following its original publication in 2014, the first edition of this book quickly became an influential text in the field. This second edition duly reflects the significant advances in knowledge and research that have been achieved in the years since.
Del 217 - Recent Results in Cancer Research
Viruses and Human Cancer
From Basic Science to Clinical Prevention
AvT.-C. Wu,Mei-Hwei Changm. fl.
Häftad, Engelska, 2021
1 250 kr
Skickas inom 10-15 vardagar
This book, in a new, extensively updated edition, covers viral infection, virus-induced inflammation and tissue injuries, viral epidemiology, oncogenic mechanisms, and current and emerging preventive and therapeutic strategies in detail. Readers will also find information on the individual aspects of a number of oncogenic viruses, including hepatitis B, hepatitis C, human papillomavirus, Epstein–Barr virus, human T-cell lymphotropic virus, Kaposi sarcoma-associated herpes, and Merkel cell polyomavirus, as well as associated human cancers. The book will benefit all those who are seeking a comprehensive, up-to-date overview of the basic and clinical aspects of oncogenic viruses and associated human cancers. Following its original publication in 2014, the first edition of this book quickly became an influential text in the field. This second edition duly reflects the significant advances in knowledge and research that have been achieved in the years since.
Del 218 - Recent Results in Cancer Research
Ethical Challenges in Cancer Diagnosis and Therapy
AvAxel W. Bauer,Ralf-Dieter Hofheinzm. fl.
Inbunden, Engelska, 2021
1 476 kr
Skickas inom 10-15 vardagar
This book presents in detail the problems and ethical challenges in daily oncological practice. In western industrialized countries, roughly 25 percent of all citizens still die from cancer. Despite significant progress in basic science and in individual areas of clinical care, even in the 21st century, being diagnosed with cancer has lost none of its dread and can still be a death sentence. This situation raises many problems and challenges for medical ethics, e.g., the question of the benefits and risks of prevention programs, or the right to know and not to know. Clinical trials with cancer patients and quality assurance for surgery, radiotherapy and medication also pose a series of ethical dilemmas. Furthermore, cancer treatment is a psychological challenge not only for patients but also for physicians and caregivers. The issues of adequate pain management and good palliative care, of treatment limiting and the question of assisted suicide at the end of life also have to be considered. In order to reflect the subject’s diverse and multifaceted nature, the book incorporates legal, ethnographic, historical and literary perspectives into ethical considerations.
Del 218 - Recent Results in Cancer Research
Ethical Challenges in Cancer Diagnosis and Therapy
AvAxel W. Bauer,Ralf-Dieter Hofheinzm. fl.
Häftad, Engelska, 2022
1 024 kr
Skickas inom 10-15 vardagar
This book presents in detail the problems and ethical challenges in daily oncological practice. In western industrialized countries, roughly 25 percent of all citizens still die from cancer. Despite significant progress in basic science and in individual areas of clinical care, even in the 21st century, being diagnosed with cancer has lost none of its dread and can still be a death sentence. This situation raises many problems and challenges for medical ethics, e.g., the question of the benefits and risks of prevention programs, or the right to know and not to know. Clinical trials with cancer patients and quality assurance for surgery, radiotherapy and medication also pose a series of ethical dilemmas. Furthermore, cancer treatment is a psychological challenge not only for patients but also for physicians and caregivers. The issues of adequate pain management and good palliative care, of treatment limiting and the question of assisted suicide at the end of life also have to be considered. In order to reflect the subject’s diverse and multifaceted nature, the book incorporates legal, ethnographic, historical and literary perspectives into ethical considerations.
Del 219 - Recent Results in Cancer Research
Liver Fluke, Opisthorchis viverrini Related Cholangiocarcinoma
Liver Fluke Related Cholangiocarcinoma
AvNarong Khuntikeo,Ross H. Andrewsm. fl.
Inbunden, Engelska, 2023
1 476 kr
Skickas inom 10-15 vardagar
This volume discusses new developments in the etiology, diagnosis, and treatment of cholangiocarcinoma induced by the liver fluke Opisthorchis viverrini. Although cholangiocarcinoma is rare in the Western world, it has a very high incidence in continental Southeast Asian countries, where it is linked to infection with O. viverrini. In Southeast Asia this cancer causes thousands of deaths every year and places a severe socioeconomic burden on the affected families. Diagnosis is usually at a late disease stage, and in the past palliative surgery and care have been the major therapeutic options. Recently, however, techniques have become available for early-stage diagnosis that offer the possibility of curative surgery, and novel chemotherapeutic options are also under development. In Thailand alone, more than 2 million individuals have now been registered for screening for this cancer. The aim of this book is to highlight the latest research in the field and to explain how the newly available techniques can be applied to reduce the risk of developing cholangiocarcinoma and increase the likelihood of survival.
Del 219 - Recent Results in Cancer Research
Liver Fluke, Opisthorchis viverrini Related Cholangiocarcinoma
Liver Fluke Related Cholangiocarcinoma
AvNarong Khuntikeo,Ross H. Andrewsm. fl.
Häftad, Engelska, 2024
1 137 kr
Skickas inom 10-15 vardagar
This volume discusses new developments in the etiology, diagnosis, and treatment of cholangiocarcinoma induced by the liver fluke Opisthorchis viverrini. Although cholangiocarcinoma is rare in the Western world, it has a very high incidence in continental Southeast Asian countries, where it is linked to infection with O. viverrini. In Southeast Asia this cancer causes thousands of deaths every year and places a severe socioeconomic burden on the affected families. Diagnosis is usually at a late disease stage, and in the past palliative surgery and care have been the major therapeutic options. Recently, however, techniques have become available for early-stage diagnosis that offer the possibility of curative surgery, and novel chemotherapeutic options are also under development. In Thailand alone, more than 2 million individuals have now been registered for screening for this cancer. The aim of this book is to highlight the latest research in the field and to explain how the newly available techniques can be applied to reduce the risk of developing cholangiocarcinoma and increase the likelihood of survival.
Del 223 - Recent Results in Cancer Research
Medullary Thyroid Carcinoma
Biology, management, and treatment of sporadic and hereditary MTC
AvFriedhelm Raue,Karin Frank-Raue
Inbunden, Engelska, 2025
1 589 kr
Skickas inom 10-15 vardagar
After 10 years, this second edition is extensively rewritten and updated and provides a source of information concerning all aspects of medullary thyroid carcinoma, including comprehensive actual references for interested scientists.Medullary thyroid carcinoma (MTC) is a rare unique tumor which differs from other thyroid tumors by originating from the neuroendocrine C-cell, secreting the specific tumor marker calcitonin. MTC is associated in about 25% of cases with multiple endocrine neoplasia type 2, an autosomal dominant familial disorder causing tumors within various endocrine glands. The molecular genetics of tumor development is clarified: hereditary as well as sporadic MTC are linked to mutations in the RET proto- oncogene coding for a tyrosine kinase. These RET mutations serve as a genetic marker for hereditary MTC and allow for prophylactic thyroidectomy in gene carriers. The RET-tyrosine kinase is also a new therapeutic target using selective tyrosine kinase inhibitors improving the outcome of advanced metastasized MTC. This book will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.
Del 223 - Recent Results in Cancer Research
Medullary Thyroid Carcinoma
Biology, management, and treatment of sporadic and hereditary MTC
AvFriedhelm Raue,Karin Frank-Raue
Häftad, Engelska, 2026
1 137 kr
Skickas inom 10-15 vardagar
After 10 years, this second edition is extensively rewritten and updated and provides a source of information concerning all aspects of medullary thyroid carcinoma, including comprehensive actual references for interested scientists.Medullary thyroid carcinoma (MTC) is a rare unique tumor which differs from other thyroid tumors by originating from the neuroendocrine C-cell, secreting the specific tumor marker calcitonin. MTC is associated in about 25% of cases with multiple endocrine neoplasia type 2, an autosomal dominant familial disorder causing tumors within various endocrine glands. The molecular genetics of tumor development is clarified: hereditary as well as sporadic MTC are linked to mutations in the RET proto- oncogene coding for a tyrosine kinase. These RET mutations serve as a genetic marker for hereditary MTC and allow for prophylactic thyroidectomy in gene carriers. The RET-tyrosine kinase is also a new therapeutic target using selective tyrosine kinase inhibitors improving the outcome of advanced metastasized MTC. This book will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.
Del 224 - Recent Results in Cancer Research
Molecular Imaging in Oncology - Volume 1
Advanced Solutions to Acquire Disease-Specific Biomarkers - Technologies and Preclinical Applications
AvOtmar Schober,Fabian Kiesslingm. fl.
Inbunden, Engelska, 2026
1 589 kr
Skickas inom 10-15 vardagar
These two books cover the most significant recent advances in oncological molecular imaging, from methods and preclinical research to clinical practice. The first book is divided into two sections. The first section focuses on standardized and emerging technologies, as well as probe designs for various imaging modalities, including advanced X-ray imaging, CT, MRI, SPECT, total body PET, ultrasound, optical imaging, optoacoustic imaging, and probes for these modalities. The section also covers artificial intelligence in radiomics. The second section focuses on preclinical applications, including advanced microscopy in animal imaging.The second book presents various clinical applications of molecular imaging and related imaging features. The first section of the second book discusses the crucial, emerging role of molecular imaging in planning and monitoring oncological therapies and future challenges and prospects in multimodality imaging. The second section discusses radiotherapy approaches (photon therapy, particle therapy, and internal therapy) and theranostics. Given its scope, this handbook will benefit anyone interested in the revolution in diagnostic and therapeutic oncology brought about by molecular imaging. A third section of the second book will venture a view of future challenges.
Del 225 - Recent Results in Cancer Research
Molecular Imaging in Oncology - Volume 2
Advanced Solutions to Acquire Disease-Specific Biomarkers - Clinical Applications
AvOtmar Schober,Fabian Kiesslingm. fl.
Inbunden, Engelska, 2026
2 041 kr
Skickas inom 10-15 vardagar
These two books cover the most significant recent advances in oncological molecular imaging, from methods and preclinical research to clinical practice. The first book is divided into two sections. The first section focuses on standardized and emerging technologies, as well as probe designs for various imaging modalities, including advanced X-ray imaging, CT, MRI, SPECT, total body PET, ultrasound, optical imaging, optoacoustic imaging, and probes for these modalities. The section also covers artificial intelligence in radiomics. The second section focuses on preclinical applications, including advanced microscopy in animal imaging.The second book presents various clinical applications of molecular imaging and related imaging features. The first section of the second book discusses the crucial, emerging role of molecular imaging in planning and monitoring oncological therapies and future challenges and prospects in multimodality imaging. The second section discusses radiotherapy approaches (photon therapy, particle therapy, and internal therapy) and theranostics. Given its scope, this handbook will benefit anyone interested in the revolution in diagnostic and therapeutic oncology brought about by molecular imaging. A third section of the second book will venture a view of future challenges.
Del 203 - Recent Results in Cancer Research
Early Gastrointestinal Cancers II: Rectal Cancer
AvFlorian Otto,Manfred P. Lutz
Inbunden, Engelska, 2014
572 kr
Skickas inom 10-15 vardagar
This Recent Results in Cancer Research volume provides an up-to-date overview of the multidisciplinary management of locally confined rectal cancer as well as colorectal cancer with synchronous resectable liver metastases. The contents comprise the majority of the invited contributions from the Second St. Gallen EORTC Gastrointestinal Cancer Conference, held on 6-8 March 2014 in St. Gallen, Switzerland. Written by some of the world’s leading experts in the imaging, endoscopy, pathology, molecular biology, surgery, radiotherapy and medical oncology of rectal cancer and liver metastases, the chapters offer a comprehensive view on the latest recommendations in diagnosis and multidisciplinary treatment. Every clinician involved in the care of patients with rectal cancer will find this book interesting and helpful.
Del 199 - Recent Results in Cancer Research
Pre-Analytics of Pathological Specimens in Oncology
AvManfred Dietel,Christian Wittekindm. fl.
Inbunden, Engelska, 2015
572 kr
Skickas inom 10-15 vardagar
This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase – the period from surgical removal of tissue to the start of pathological processing – have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up.
Del 200 - Recent Results in Cancer Research
Chromosomal Instability in Cancer Cells
AvB. Michael Ghadimi,Thomas Ried
Inbunden, Engelska, 2015
572 kr
Skickas inom 10-15 vardagar
This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
Del 205 - Recent Results in Cancer Research
Rare Hereditary Cancers
Diagnosis and Management
AvGabriella Pichert,Chris Jacobs
Inbunden, Engelska, 2016
1 137 kr
Skickas inom 10-15 vardagar
This book approaches the differential diagnosis and management of rare, hereditary cancer syndromes from a practical angle, addressing the issues pertinent to each tumour type as encountered by health professionals in their day-to-day practice. This book enables readers to correctly identify patients with rare cancer syndromes who would benefit from genetic counselling and testing, and provides the necessary knowledge for appropriate patient management and advising at-risk family members. It begins by describing recent advances in genetic testing for cancer-predisposing genes. Leading experts from Europe and Australia then offer detailed, up-to-date guidance on the diagnosis and management of a wide range of hereditary cancers. The concluding chapter examines the wider issues that are raised by genetic testing for rare cancer syndromes for patients, families and health professionals. This book is an invaluable source of information for all specialists involved in the care of suchpatients and their families.
Del 200 - Recent Results in Cancer Research
Chromosomal Instability in Cancer Cells
AvB. Michael Ghadimi,Thomas Ried
Häftad, Engelska, 2016
572 kr
Skickas inom 10-15 vardagar
This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
Pre-Analytics of Pathological Specimens in Oncology
AvManfred Dietel,Christian Wittekindm. fl.
Häftad, Engelska, 2016
572 kr
Skickas inom 10-15 vardagar
This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase – the period from surgical removal of tissue to the start of pathological processing – have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up.
Medullary Thyroid Carcinoma
Biology – Management – Treatment
AvFriedhelm Raue
Häftad, Engelska, 2016
1 475 kr
Skickas inom 11-20 vardagar
This book offers a comprehensive overview of medullary thyroid carcinoma, both in the more common sporadic form and in the familial form, multiple endocrine neoplasia (MEN) types 2A and 2B. The coverage includes, but is not limited to, molecular biology and genetics, pathology, clinical presentation, imaging techniques, surgical treatment, and follow-up. The role of calcitonin as a highly sensitive and specific tumor marker for the screening, diagnosis, and follow-up of MTC and metastatic disease is described, and the significance of other tumor markers is also considered. With regard to treatment, the use of thyroidectomy is fully discussed, including in children carrying the mutations in the RET proto-oncogene considered causative for MEN 2. Additionally, the value of tyrosine kinase inhibitors as the most effective treatment modality in patients with a large tumor burden or rapid tumor growth, or both, is explained. Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type 2 will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.
Del 203 - Recent Results in Cancer Research
Early Gastrointestinal Cancers II: Rectal Cancer
AvFlorian Otto,Manfred P. Lutz
Häftad, Engelska, 2016
572 kr
Skickas inom 10-15 vardagar
This Recent Results in Cancer Research volume provides an up-to-date overview of the multidisciplinary management of locally confined rectal cancer as well as colorectal cancer with synchronous resectable liver metastases. The contents comprise the majority of the invited contributions from the Second St. Gallen EORTC Gastrointestinal Cancer Conference, held on 6-8 March 2014 in St. Gallen, Switzerland. Written by some of the world’s leading experts in the imaging, endoscopy, pathology, molecular biology, surgery, radiotherapy and medical oncology of rectal cancer and liver metastases, the chapters offer a comprehensive view on the latest recommendations in diagnosis and multidisciplinary treatment. Every clinician involved in the care of patients with rectal cancer will find this book interesting and helpful.
Del 207 - Recent Results in Cancer Research
Metabolism in Cancer
AvThorsten Cramer,Clemens A. Schmitt
Inbunden, Engelska, 2016
1 589 kr
Skickas inom 10-15 vardagar
This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications.Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.
Del 208 - Recent Results in Cancer Research
Obesity and Cancer
AvTobias Pischon,Katharina Nimptsch
Inbunden, Engelska, 2016
1 815 kr
Skickas inom 10-15 vardagar
This book provides a comprehensive and up-to-date review of the relationship between obesity and cancer. It opens with a global perspective on obesity and cancer incidence, followed by in-depth discussions of those cancers for which we have sufficient evidence of a causal relationship with obesity. It addresses topics such as the effects of obesity on cancer incidence and cancer survival, the effects of weight gain and weight loss in adulthood on cancer risk, the effects of childhood and adolescent obesity, and the role of body fat distribution in cancer risk. Individual chapters discuss potential pathways for the observed associations and explore possible mechanisms from both an epidemiological and an experimental perspective. It concludes with a population perspective on the cancer risk that is attributable to obesity and is thus potentially avoidable. This book is of particular value to researchers and epidemiologists and is also of interest to public health workers and clinicians.
Current Strategies in Cancer Gene Therapy
AvWolfgang Walther
Inbunden, Engelska, 2017
1 589 kr
Skickas inom 10-15 vardagar
This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies. Many of the described strategies focus on the generation of more efficient and specific means of attack at known and novel cellular targets associated with tumor development and progression. The book also details parallel improvements in vector design, vector delivery, and therapeutic efficacy. It offers readers a stimulating, broad overview of advances in the field, linking experimental strategies to their clinical applications.

Recent Results in Cancer Research – serie

Regulatory and Economic Aspects in Oncology

Small Molecules in Hematology

Small Molecules in Oncology

Current Immunotherapeutic Strategies in Cancer

Current Immunotherapeutic Strategies in Cancer

Tumor Liquid Biopsies

Tumor Liquid Biopsies

Molecular Imaging in Oncology

Molecular Imaging in Oncology

Viruses and Human Cancer

Viruses and Human Cancer

Ethical Challenges in Cancer Diagnosis and Therapy

Ethical Challenges in Cancer Diagnosis and Therapy

Liver Fluke, Opisthorchis viverrini Related Cholangiocarcinoma

Liver Fluke, Opisthorchis viverrini Related Cholangiocarcinoma

Medullary Thyroid Carcinoma

Medullary Thyroid Carcinoma

Molecular Imaging in Oncology - Volume 1

Molecular Imaging in Oncology - Volume 2

Early Gastrointestinal Cancers II: Rectal Cancer

Pre-Analytics of Pathological Specimens in Oncology

Chromosomal Instability in Cancer Cells

Rare Hereditary Cancers

Chromosomal Instability in Cancer Cells

Pre-Analytics of Pathological Specimens in Oncology

Medullary Thyroid Carcinoma

Early Gastrointestinal Cancers II: Rectal Cancer

Metabolism in Cancer

Obesity and Cancer

Current Strategies in Cancer Gene Therapy