E. Grundmann – författare
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45 produkter
45 produkter
E-bok
PDF, Engelska, 2013779 kr
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Recent Results in Cancer Research: Current Problems in the Epidemiology of Cancer and Lymphomas is a collection of papers that tackles the various areas of concerns in cancer research. The text covers the general problems, such as the histopathological definition and classification of tumors. The book also deals with the various types of cancer, such as breast, liver, and prostrate cancers. The selection will be of great use for medical researchers and practitioners, particularly those who are involved in treating and studying cancers.
Häftad, Engelska, 1974
1 112 kr
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Häftad, Tyska, 1975
575 kr
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Häftad, Tyska, 1994
523 kr
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Die Beurteilung der Krankheitsverläufe von Tumorpatienten und deren Prognose bedarf - ebenso wie die onkologische Qualitätskontrolle - einer systematischen Dokumentation. Voraussetzung für die Vergleichbarkeit der vom Patienten gewonnenen Daten und deren sinnvolle Auswertung ist eine nach einheitlichen Kriterien durchgeführte Erhebung, wie sie die Basisdokumentation vorschlägt. In der vorliegenden vierten Auflage werden die Standards für die Dokumentation von Diagnostik, Therapie, Krankheitsverlauf und Status bei Abschluß der Betreuung definiert, die auf Empfehlung der "Arbeitsgemeinschaft Deutscher Tumorzentren" (ADT) bei jedem Tumorpatienten angewandt werden sollten.
Häftad, Tyska, 1997
627 kr
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Das vorliegende Werk in Buch- und Diskettenform ist die Übersetzung des Morphologieteils der englischen ICD-0-Ausgabe aus dem Jahre 1990. Berücksichtigt wurden die neu eingeführten Tumor-Entitäten mit Anmerkungen zur Diagnostik und die histologisch-zytologische Charakterisierung dieser Tumoren. Auf diese Weise ist eine alle Tumoren umfassende aktuelle Klassifikation entstanden. Für die Kodierung auf den Meldebogen aller Tumorregister ist dieses Buch unverzichtbar.
E-bok
PDF, Tyska, 2013566 kr
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Häftad, Tyska, 2012
575 kr
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Die Orthologie und Pathologie des Wachstums und der Differenzierung waren schon Gegenstand des 1955 erschienenen Bandes VI!I dieses Handbuches. Seine von Biologen und Pathologen verfaßten Kapitel stützten sieh auf die Ergebnisse der klassischen Morphologie. Die morphologischen Probleme des Wachstums standen dabei ganz im Mittelpunkt. Mit der systematischen Anwendung biochemischer Methoden, der Histo autoradiographie zur Markierung der Reduplikationsphase der DNS sowie der RNS- und Protein-Synthese, der Cytophotometrie zur quantitativen Messung der Nueleinsäuren und schließlich der elektronenmikroskopischen Cytologie standen in der Erforschung der Orthologie und Pathologie des Wachstums seit einem .Jahrzehnt Methoden von vorher ungeahnter Aussagekraft zur Vel"fügung. So wird jeder, der sich in den vorliegenden Band vertieft, feststellen, daß der Einsatz dieser Methoden zu einer stürmischen Entfaltung der Erforschung von Wachstum und Differenzierung geführt hat. In der Konfrontierung dieses Bandes mit dem 1955 erschienenen wird er zugleich voller Respekt erkennen, wievieles schon in der klassischen Biologie und Pathologie zu diesem Thema grundgelegt war und bis heute fortwirkt. Im ersten Beitrag des vorliegenden Bandes vermittelt R. SCH1NDLER-Bern einen Überblick über "die Biochemie der Regeneration". Er berichtet über Struktur und Synthese der DNS, deren Störungen durch chemische Faktoren und strahlende Energie, erörtert die RNS-Synthese sowie die Synthese der Proteine und ihre Störungen. Ausführlich stellt er dann die Regulation und den Ablauf der biochemischen Vorgänge während der Regenerationsprozesse am Beispiel der Oberflächenepithelien, der Zellkulturen und bei der Leberregeneration dar und behandelt schließlich die Frage nach denProliferations-auslösenden bio chemischen Faktoren.
E-bok
PDF, Tyska, 2013652 kr
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Das vorliegende Werk in Buch- und Diskettenform ist die Übersetzung des Morphologieteils der englischen ICD-0-Ausgabe aus dem Jahre 1990. Berücksichtigt wurden die neu eingeführten Tumor-Entitäten mit Anmerkungen zur Diagnostik und die histologisch-zytologische Charakterisierung dieser Tumoren. Auf diese Weise ist eine alle Tumoren umfassende aktuelle Klassifikation entstanden. Für die Kodierung auf den Meldebogen aller Tumorregister ist dieses Buch unverzichtbar.
Häftad, Tyska, 2013
575 kr
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E-bok
PDF, Engelska, 20121 459 kr
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Häftad, Engelska, 2011
1 112 kr
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E-bok
PDF, Engelska, 20121 408 kr
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Häftad, Engelska, 2011
1 112 kr
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E-bok
PDF, Engelska, 2012734 kr
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Häftad, Engelska, 2012
559 kr
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Häftad, Engelska, 2012
1 112 kr
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(North American) Blastomycosis is caused by the dimorphic fungus Blastomyces dermati- tidis, first described by Gilchrist andStokes in 1896. The perfect stage was grown by Mc- Donough and Lewis in 1967 and is known as Ajellomyces dermatitidis. In the body and on appropriate media at 37 C, the organism presents itself as a round, thick-walled budding yeast cell, characteristically with a broad porus between mother and daughter cells. The yeast cell is multinucleated. For many years, North America was assumed to be the only place where blastomycosis was found, but recent demonstration of indigenous African cases changed this impression (Emmons et al., 1964). Within the United States, more cases are seen in Kentucky, Ohio, the Carolinas, Illinois, Michigan, Wisconsin, Iowa, Tennessee, Arkansas, and the Virginias than in the remainder of the country (Chick, 1971). In Mexico, occasionally, and in the provinces of Canada adjacent to the endemic areas of the United States, endemic blasto- mycosis has been recognized. Soil has been long suspected as the habitat for the fungus, but recovery from soil has seldom been successful (Denton and Di Salvo, 1964).The primary infection is, as a rule, pulmonary with frequent secondary foci in skin, bone, male genital system, and, eventually, spares no organ in widely disseminated cases. The rare cases of primary cutaneous blastomycosis are consequences of accidental percutaneous laboratory infection. These can be clinically easily differentiated from the average case of secondary hematogenous spread to the skin (Landay and Schwarz, 1971).
E-bok
PDF, Engelska, 20121 459 kr
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Häftad, Engelska, 2011
1 112 kr
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E-bok
PDF, Engelska, 20121 459 kr
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1. Concepts on the Causal Genesis of Human Intestinal Tumors The action of chemical substances has a significant role in the genesis of human tumors. It is assumed that most human tumors are induced by exogenous chemical noxae (Schmahl, 1970;Heidelberger, 1975; and others). In the course of intensive efforts to discover the principles of tumor etiology, important insights have resulted in recent years. These are that chemical carcinogens do not only arise as products of our tech nological civilization, but that they also occur in nature as potent solitary carcinogens and cocarcinogens (e. g. , as plant products). For review, see Hecker (1972) and Preuss mann (1975). Not only "complete" carcinogens are significant for the genesis of tu mors, but also substances which are first transformed to the actual carcinogenic com pound in the organism (Schmahl, 1975). The causal significance of exogenous noxae in carcinogenesis is indicated by the fact emphasized by Bauer (1963) that malignant tumors occur predilectively at those sites in the body which are in direct or indirect contact with the environment. This applies especially to the intestinal tract.
Häftad, Engelska, 2011
1 112 kr
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1. Concepts on the Causal Genesis of Human Intestinal Tumors The action of chemical substances has a significant role in the genesis of human tumors. It is assumed that most human tumors are induced by exogenous chemical noxae (Schmahl, 1970;Heidelberger, 1975; and others). In the course of intensive efforts to discover the principles of tumor etiology, important insights have resulted in recent years. These are that chemical carcinogens do not only arise as products of our tech nological civilization, but that they also occur in nature as potent solitary carcinogens and cocarcinogens (e. g. , as plant products). For review, see Hecker (1972) and Preuss mann (1975). Not only "complete" carcinogens are significant for the genesis of tu mors, but also substances which are first transformed to the actual carcinogenic com pound in the organism (Schmahl, 1975). The causal significance of exogenous noxae in carcinogenesis is indicated by the fact emphasized by Bauer (1963) that malignant tumors occur predilectively at those sites in the body which are in direct or indirect contact with the environment. This applies especially to the intestinal tract.
E-bok
PDF, Engelska, 20121 459 kr
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Häftad, Engelska, 2011
1 112 kr
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E-bok
PDF, Engelska, 20121 408 kr
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Due to the topology and structure of the lymph nodes, their role in the pathogenesis and development of diseases is a very special one. Each organ and even each organ-related region of the body has its own group of lymph nodes, specific topological reactions, such as in circumscribed inflammation or in the metastatic spread of malignant tumors. On the other hand, all the lymph nodes of an organism join in a uniform function effected by highly differentiated structures. Volume 84 of Current Topics in Pathology presents our current knowledge about the structure and reaction patterns of this "sec ondary" lymphoid organ. Despite our original intention to publish all the contributions in one book, it became necessary to divide them: Part 1 focuses on the involved nodal compartments, cell types, and functions, while Part 2 describes their reactions in inflammatory, neo plastic, and immune-deficient diseases. Even with the cooperation of more than 30 authors, the coverage cannot be exhaustive. The scope of both parts is limited to those reactions that can be described by direct and indirect morphological methods, including modern tech niques such as immune electron microscopy.
Häftad, Engelska, 2011
1 112 kr
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Due to the topology and structure of the lymph nodes, their role in the pathogenesis and development of diseases is a very special one. Each organ and even each organ-related region of the body has its own group of lymph nodes, specific topological reactions, such as in circumscribed inflammation or in the metastatic spread of malignant tumors. On the other hand, all the lymph nodes of an organism join in a uniform function effected by highly differentiated structures. Volume 84 of Current Topics in Pathology presents our current knowledge about the structure and reaction patterns of this "sec ondary" lymphoid organ. Despite our original intention to publish all the contributions in one book, it became necessary to divide them: Part 1 focuses on the involved nodal compartments, cell types, and functions, while Part 2 describes their reactions in inflammatory, neo plastic, and immune-deficient diseases. Even with the cooperation of more than 30 authors, the coverage cannot be exhaustive. The scope of both parts is limited to those reactions that can be described by direct and indirect morphological methods, including modern tech niques such as immune electron microscopy.
E-bok
PDF, Engelska, 20121 408 kr
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This second volume reports on the reaction patterns of lymph nodes in neoplastic and immunodeficient diseases. Based on the contents of volume 1, it presents a detailed survey of lymph node structures and their cellular components under these conditions. The patterns of nodal reactions to the development and spread of cancer have recently been investigated and discussed by several authors. Here, the immediate interactions between tumor tissue and the regional nodes have been assessed in experimental models and in human material. Using modern morphological methods such as im munohistochemistry on the light and electron microscopic level, new insights have been gained into the stepwise process of lymphogenous metastasis. Macrophages/reticulum cells were found to playa signifi cant role in this process, which is duly emphasized. Based on appro priate animal models, one chapter focuses on various subtypes of these cellular elements and their role in the two separate phases of tumor spread and the development of true metastases. The induction of fibronectin in lymph nodes is effected by tumor cells forming a special part of the extracellular matrix. The multifunctional fibronec tin molecule serves as a mediator between tumor cells and fibroblasts, furthering the formation of tumor stroma. This volume also contains a comprehensive survey of primary im munodeficiency syndromes and their nodal manifestations, reference being made to the most recent immunological knowledge.
Häftad, Engelska, 2011
1 112 kr
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This second volume reports on the reaction patterns of lymph nodes in neoplastic and immunodeficient diseases. Based on the contents of volume 1, it presents a detailed survey of lymph node structures and their cellular components under these conditions. The patterns of nodal reactions to the development and spread of cancer have recently been investigated and discussed by several authors. Here, the immediate interactions between tumor tissue and the regional nodes have been assessed in experimental models and in human material. Using modern morphological methods such as im munohistochemistry on the light and electron microscopic level, new insights have been gained into the stepwise process of lymphogenous metastasis. Macrophages/reticulum cells were found to playa signifi cant role in this process, which is duly emphasized. Based on appro priate animal models, one chapter focuses on various subtypes of these cellular elements and their role in the two separate phases of tumor spread and the development of true metastases. The induction of fibronectin in lymph nodes is effected by tumor cells forming a special part of the extracellular matrix. The multifunctional fibronec tin molecule serves as a mediator between tumor cells and fibroblasts, furthering the formation of tumor stroma. This volume also contains a comprehensive survey of primary im munodeficiency syndromes and their nodal manifestations, reference being made to the most recent immunological knowledge.
E-bok
PDF, Engelska, 20121 459 kr
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Häftad, Engelska, 2011
1 112 kr
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E-bok
PDF, Engelska, 20121 408 kr
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Häftad, Engelska, 2012
1 112 kr
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E. GRUNDMANN On behalf of the "Gesellschaft zur Bekampfung der Krebskrankheiten Nordrhein- Westfalen e. V. " I welcome you in Dusseldorf. During these two days problems of oncogenesis have to be discussed. The participants have been selected with the inten- tion of giving a review of the various fields which have some bearing on this topic. So you see here biochemists, cytologists, pathologists, immunologists, pharmacologists, virologists, and so on. Only by extensive cooperation of all scientists concerned in this field can this difficult problem of carcinogenesis ever be cleared up. Once the causal relations have been identified, we may have a reliable basis for cancer treat- ment. Research on oncogenesis is of great interest, but it is only a part of the worldwide cancer campaign. It is our hope that this symposium will contribute towards helping the cancer patient. He is the center of all our efforts. Keeping this in mind - let us begin! General Problems of Carcinogenesis Molecular Mechanisms in Chemical Carcinogenesis P. N.MAGEE Covalent binding of metabolites of the hepatocarcinogenic azo dye p-dimethyl- aminoazobenzene (DAB) to proteins of the livers of rats to which it had been ad- ministered was observed by JAMES and ELIZABETH MILLER in 1947. Since then a large amount of work on the interaction of many other chemical carcinogens with cellular macromolecules has been reported.