Cancer Clinical Trials

A Critical Appraisal

AvHans Scheurlen,Richard Kay

Häftad, Engelska, 2011

Del i serien Recent Results in Cancer Research

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Beskrivning

The meeting was generously supported again by the Federal Ministry of Research and Technology (Bundesministe rium flir Forschung und Technologie, BMFT) within the framework of the West German BMFT Breast Cancer Study Group.

Produktinformation

Utgivningsdatum:2011-12-27
Mått:170 x 244 x 21 mm
Vikt:506 g
Format:Häftad
Språk:Engelska
Serie:Recent Results in Cancer Research
Antal sidor:272
Förlag:Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN:9783642834219

Utforska kategorier

Matematisk statistik inom Naturvetenskap och teknik
Onkologi inom Medicin

Innehållsförteckning

Scientific Fundamentals.- The Crooked Path Toward the Objectivation of Therapeutic Experience.- Randomised Trials: The Case for Science in Medicine.- A Critical Assessment of Approaches to Improving the Efficiency of Cancer Clinical Trials.- Statistical Standards for Protocols and Protocol Deviations.- The Design of Cancer Prevention Trials.- Heterogeneous Treatment Effects.- Strategies for Subgroup Analysis in Clinical Trials.- Statistical Tools for Subset Analysis in Clinical Trials.- Competing Risks, Interactions and Crossing Hazards.- Significance Testing in the Comparison of Survival Curves from Clinical Trials of Cancer Treatment.- Estimating the Magnitude of Benefits from Adjuvant Therapy.- Treatment by Protocol: Assessment of Gains and Losses.- On Combining Information: Historical Controls, Overviews, and Comprehensive Cohort Studies.- The Use of Data Bases and Historical Controls in Treatment Comparisons.- Limitations and Advantages of Meta-analysis in Clinical Trials.- Overview of Adjuvant Radiotherapy for Breast Cancer.- Overview of Randomized Trials of Postoperative Adjuvant Radiotherapy in Breast Cancer.- Combining Randomized and Nonrandomized Patients in the Statistical Analysis of Clinical Trials.- The Comprehensive Cohort Study: The Use of Registry Data to Confirm and Extend a Randomized Trial.- Subjective Opinions and Informed Consent.- Treatment Decisions in Breast Cancer.- Randomization and Follow-up Care of Patients in a Breast Cancer Clinical Trial: Personal Experience.- Alternative Treatments for Small Cancers of the Breast: Motives and Preferences of Patients Having to Choose.- Subjective Theories on Etiology and Treatment of Cancer.- Individual Cases and the Scientific Method—A Conflict? Legal Aspects of Cancer Clinical Trials in the FederalRepublic of Germany.- The Value of Small Clinical Trials.- A Predictive Approach to Selecting the Size of a Clinical Trial, Based on Subjective Clinical Opinion.- Statistical Properties and Use of Sequential Methods in Randomized Clinical Trials when the Response Criterion Is Censored.- Assessment of Quality of Life.- Measurement of Quality of Life in Clinical Trials of Therapy.- A Modular Approach to Quality-of-Life Assessment in Cancer Clinical Trials.- Effects of Breast Conservation on Psychological Morbidity Associated with Diagnosis and Treatment of Early Breast Cancer.- Evaluation of Psychosocial Aspects in a Breast Preservation Trial.