This book focuses on theories and applications of mathematics, statistics, and computing, where they intersect to address real-world problems in various industries. The papers contained within were presented at the 8th ICoMS—International Conference on Mathematics and Statistics, held in Athens, Greece, from September 24–26, 2025.Organized annually since 2018, the ICoMS conference brings together leading researchers and practitioners from around the world to exchange knowledge and foster cross-disciplinary collaboration in both theoretical and applied fields. The core themes of the conference include, but it is not limited to, statistical inference, computational techniques, and applications involving high-dimensional data and complex datasets.