Translating neuroscientific, neurological, and psychiatric research into effective therapies remains a major challenge for both academic researchers and industry experts. This open access volume reviews the progress achieved over the past decade and provides an outlook on emerging concepts, technologies, and diverse therapeutic modalities. The book brings together leading experts to review and discuss the current state of translational neuroscience, spanning recent discoveries in the underlying mechanisms, cutting‑edge technologies, advances in therapeutic development, and the application of artificial intelligence. The first section focuses on key challenges in translational psychiatry, with dedicated chapters on autism spectrum disorder, bipolar disorder, and novel treatment approaches, including neuromodulation and psychedelics, as well as an overview of patient stratification strategies in psychiatry. Additional chapters provide a comprehensive review of translating research in Alzheimer’s disease and Parkinson’s disease into the clinics. The volume concludes with an extensive section highlighting innovative strategies, novel model systems, and AI‑based approaches to advance translational research for neurological disorders.This up‑to‑date reference not only summarizes the current understanding and therapeutic landscape for major neurodegenerative and neuropsychiatric diseases but also highlights future directions and emerging opportunities in translational neuroscience. We expect that it will encourage others to embark on the arduous but rewarding path towards new medicines and therapies for patients with neurological or psychiatric conditions.“A rather comprehensive volume on recent advances in translational neuroscience that have (and will) meaningfully impact on the treatment landscape for the major neuropsychiatric disorders. The authors have done a masterful job at bridging recent basic neuroscience findings as they apply to fundamental disease biology, identifying both gaps in current knowledge and major advances …. and nicely capturing how such information is being effectively “translated“ to new and improved and more “precise“ treatments The volume is both sobering and inspiring, underscoring the challenges and opportunities of this important scientific discipline, and is a must read for those interested in better understanding some of the most common and disabling of all brain disorders”. Steve Paul, MD Washington University of St. Louis School of Medicine.“This book offers a comprehensive and engaging account of modern translational neuroscience, spanning molecular mechanisms to therapeutic possibilities, with a rare breadth across psychiatric and neurodegenerative disorders”. Tony Wyss-Coray, PhD, Stanford University.“This is an interdisciplinary, timely and inspiring book, a thoughtful synthesis by the authors. As they describe with compassion and compelling examples, brain disorders that emerge during childhood or aging pose formidable personal, medical and socioeconomic problems. Fortunately, as also effectively highlighted in this book, there is good reason for hope: new insights into disease mechanisms are being gained at an unprecedented pace, and several of those insights will likely enable the development of better therapeutic strategies, which are awaited so very urgently by patients, families and physicians alike”. Lennart Mucke, MD, University of California.
