This book contains the refereed proceedings of the First International Conference on Information Systems for Crisis Response and Management in Mediterranean Countries, ISCRAM-med 2014, held in Toulouse, France, in October 2014.The aim of ISCRAM-med was to gather researchers and practitioners working in the area of Information Systems for Crisis Response and Management, with a special but not limited focus on Mediterranean crises. These include political crises, economic crises, natural hazards, and fatal industrial incidents.The 15 full papers included in this book were carefully reviewed and selected from 44 submissions. The contributions are organized in topical sections on supply chain and distribution; modeling and training; human interactions in the crisis field; coordination and agility; and social aspects in crisis management.