This book constitutes the refereed proceedings of the 15th International Scientific Conference on Information Technologies and Mathematical Modeling, named after A. F. Terpugov, ITMM 2016, held in Katun, Russia, in September 2016.The 33 full papers presented together with 4 short papers were carefully reviewed and selected from 96 submissions. They are devoted to new results in the queueing theory and its applications, addressing specialists in probability theory, random processes, mathematical modeling as well as engineers dealing with logical and technical design and operational management of telecommunication and computer networks.