Nitrite and Nitrate in Human Health and Disease

Nathan S. Bryan, PhDAssistant ProfessorInstitute of Molecular MedicineThe University of Texas health Science Center at HoustonHouston, TX Joseph Loscalzo, MD, PhDHersey Professor of the Theory and Practice of MedicineHarvard Medical School;Chairman, Department of MedicineBrigham and Women’s Hospital;President, Brigham Medical Research and Education Foundation, Inc., Boston, MA, USA

• Section I: Biochemistry, Molecular Biology, Metabolism, and Physiology.- Introduction.- From Atmospheric Nitrogen to Bioactive Nitrogen Oxides.- Nitrate Reducing Oral Bacteria: Linking Oral and Systemic Health.- Epigenetics and the Regulation of Nitric Oxide.- The Mitochondrion: A Physiological Target of Nitrite.- Sources of Exposure to Nitrogen Oxides.- Section II: Food and Environmental Exposures to Nitrite and Nitrate.- History of Nitrite and Nitrate in Food.- Nutritional Epidemiology of Nitrogen Oxides: What do the Numbers Mean?.- Nutritional Impact on the Nitric Oxide Pathway.- Dietary Flavonoids as Modulators of NO Bioavailability in Acute and Chronic Cardiovascular Diseases.- Nitrite and Nitrate in Human Breast Milk: Implications for Development.- Regulation of Dietary Nitrate and Nitrite: Balancing Essential Physiological Roles with Potential Health Risks.- Section III: Nitrite and Nitrate in Therapeutics and Disease.- Nitric Oxide Signaling in Health and Disease.- Inhaled Nitric Oxide.- Pharmacology of Nitrovasodilators.- Nitrite and Nitrate in Ischemia-Reperfusion Injury.- The Nitrate-Nitrite-Nitric Oxide Pathway in Traditional Herbal Medicine and Dietary Supplements with Potential Benefits for Cardiovascular Diseases.- Nitrate and Nitrite and Aging and Age-Related Disease.- Nitrite and Nitrate as a Treatment for Hypertension.- Nitrate in Exercise Performance.- Nitrite and Nitrate in Cancer.- Looking Forward.