Mechanisms of Vascular Defects in Diabetes Mellitus

Dr.  Chandrasekharan C.  Kartha is an Honorary Distinguished Professor in the Division of Cardiovascular Diseases and Diabetes Biology at Rajiv Gandhi Center for Biotechnology at Thiruvananthapuram, India. He is a pathologist by training and has made significant contributions to the understanding of the cellular and molecular mechanisms of vascular diseases and endomyocardial fibrosis, a tropical cardiomyopathy. He is an elected fellow of Royal College of Physicians (London), International Academy of Cardiovascular Sciences, National Academy of Medical Sciences (India) National Academy of Sciences (India) and Indian Academy of sciences. He has served on the editorial boards of several journals and in grant review committees of several India government agencies funding medical research and science and technology activities. He has organized several national and international conferences on cardiovascular themes and has been an invited speaker at several national andinternational meetings. He has published more than 120 papers in refereed journals, 15 chapters in books and edited 5 books. He is the current President of Academy of Cardiovascular Sciences, the India section of International Academy of Cardiovascular Sciences.

• Section 1 Introduction.- The Global Burden Of Diabetes And Its Vascular Complications.- SECTION 2 Pathogenesis.- Genetic Basis For Increased Risk For Vascular Diseases In Diabetes.- Vascular Remodelling In Diabetes Mellitus.- Pathogenesis Of The Plaque Vulnerability In Diabetes Mellitus.- Endothelial Dysfunction In Diabetes.- Smooth Muscle Cells In Diabetes Mellitus.- Monocytes Factors In Pathogenesis Of Vascular Lesions In Diabetes.- Endothelial Progenitor Cell Dysfunction In The Pathogenesis Of Vascular Complications Of Diabetes.- Pathogenetic mechanisms in diabetic retinopathy: from molecules to cells to tissues.- Perspectives on the vascular pathogenesis of diabetic neuropathy.- SECTION 3 Molecular mechanisms.- The Renin - Angiotensin System And Diabetes.- Adipokines And Vascular Disease In Diabetes.- G-Proteins In Vascular Complications Of  Diabetes.- Histone Deacetylases In Vascular Pathophysiology: Regulation By Vasoactive Peptides And Growth Factors.- Role of non-coding RNAs in vascular complications of diabetes mellitus.- SECTION 4 Hemostatic Factors.- Diabetes As A Prothrombotic State.- Mechanisms Of Hypercoagulation And Aberrant Clot Lyses In Type 2 Diabetes.- Platelet Dysfunction In Type-2 Diabetes Mellitus.- SECTION 5 Metabolic Factors.- Advanced Glycation End Products In Diabetic Complications.- Atherogenicdyslipoproteinemia In Type 2 Diabetes Mellitus.- Vascular Remodeling: Homocysteine And Diabetes.- SECTION 6 Pharmacological Therapies.- Mechanisms Of Action Of Drugs For Treating Endothelial Dysfunction In Diabetes Mellitus.- Beneficial Effects Of Inorganic Nitrate/Nitrite On Vascular Function And Blood Pressure In Diabetes.- Myeloperoxidase (MPO): Do We Need Inhibitors?.