Targeting Trafficking in Drug Development

Inbunden, Engelska, 2018

Del i serien Handbook of Experimental Pharmacology

3 266 kr

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Beskrivning

This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.

Produktinformation

Utgivningsdatum:2018-04-27
Mått:155 x 235 x undefined mm
Format:Inbunden
Språk:Engelska
Serie:Handbook of Experimental Pharmacology
Antal sidor:425
Förlag:Springer International Publishing AG
ISBN:9783319741635

Utforska kategorier

Cellbiologi inom Naturvetenskap och teknik
Farmakologi inom Medicin
Tillverkningsteknik inom Naturvetenskap och teknik

Innehållsförteckning

1. Intracellular trafficking of gonadotropin receptors in health and disease.- 2. Investigating internalization and intracellular trafficking of GPCRs.- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors.- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases.- 5. Pharmacoperones for misfolded gonadotropin receptors.- 6. Pharmacological chaperones: Beyond conformational disorders.- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer.- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches.- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking.- 10. SLC6 transporter folding diseases and pharmacochaperoning.- 11. The molecular physiopathogenesis of islet amyloidosis.- 12. Folding defects leading to primary hyperoxaluria.- 13. Potentialpharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria.