New Approaches to Drug Discovery

Häftad, Engelska, 2018

Del i serien Handbook of Experimental Pharmacology

2 180 kr

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Beskrivning

This volume gives an overview ofstate of the art technologies and future developments in the field ofpreclinical pharmaceutical research. The lead generation part as a next step focuses on the requirements andtechnologies to identify new small molecules as lead compounds for furtheroptimization;

Produktinformation

Utgivningsdatum:2018-04-25
Mått:155 x 235 x 18 mm
Vikt:598 g
Format:Häftad
Språk:Engelska
Serie:Handbook of Experimental Pharmacology
Antal sidor:341
Förlag:Springer International Publishing AG
ISBN:9783319804552

Utforska kategorier

Farmakologi inom Medicin
Kemi inom Naturvetenskap och teknik
Biovetenskap inom Naturvetenskap och teknik

Mer om författaren

Dr. Ulrich Nielsch, Bayer Pharma AG,Wuppertal, GermanyDr. Ulrike Fuhrmann, Bayer Pharma AG, Berlin, GermanyProf. Dr. Stefan Jaroch, Bayer Pharma AG, Berlin, Germany

Innehållsförteckning

Preface.-Part 1. Historical View.- Drug discovery in the past and today.Part 2. Target Discovery.- Emerging target families:intractable targets. In vivo target validation especially for biologicaltargets. HR RNAi/High Content analysis.- Part 3. Lead generation and Optimization.- Sources for leads: natural products,libraries. Screening: assays, readout, technology. Impact of structuralbiology, fragment based screening/Virtual screening. Predictive in silico toolsof compound properties. High throughput synthesis. New compound classes:Protein-Protein Interaction. Sources for biological leads/Screening ofbiologicals.- Part 4. Test systems forEfficacy and Safety.- In vitro/ Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impactof biomarkers/personalized medicine. Simulating in vivo drug effects.

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