Functional Nucleus

Häftad, Engelska, 2018

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Beskrivning

Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases.

Produktinformation

Utgivningsdatum:2018-06-23
Mått:155 x 235 x 28 mm
Vikt:779 g
Format:Häftad
Språk:Engelska
Antal sidor:513
Förlag:Springer International Publishing AG
ISBN:9783319817682

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Mer om författaren

David P. Bazett-JonesThe Hospital for Sick Children, Toronto, ON, Canada Graham DellaireDalhousie University, Halifax, NS, Canada

Innehållsförteckning

Part I - Nuclear Periphery.- 1.Laminopathies/Howard Worman.- Part II Nuclear Bodies.- 2.Nucleolus/Marie-Line Dubois and François-Michel Boisvert.- 3.Speckles/splicing and disease/Michael Ladomery and Sebastian Oltean.- 4.PML, cancer and stem cells/Julia P. Hofmann and Paolo Salomoni.- Part III Chromosomes.- 5.Chromosome territories/Karen J. Meaburn, Bharat Burman and Tom Misteli.- 6.Telomeres and Chromosome Instability/Tsz Wai Chu and Chantal Autexier.- PART IV Nuclear Domains and Development.- 7.Polycomb bodies/Vincenzo Pirrotta.- 8.Ikaros domains/Karen E. Brown.- PART V Nuclear Domains and Cell Stress.- 9.Senescence/SAHFs/Tamir Chandra.- 10.DNA repair foci as facultative nuclear domains/Michael J. Hendzel and Hilmar Strickfaden.- 11.DNA damage and the nucleus/Jordan Pinder, Anastazja Grabarz, Evi Soutoglou and Graham Dellaire.- 12.Inflammation and the nucleus/Sona Hubackova , Simona Moravcova and Zdenek Hodny.- 13.Viral infection and the nucleus/Lori Frappier.- PART VI Macromoleculardynamics within the nucleus.- 14.Actin filaments/motors/Guillaume Huet and Maria K. Vartiainen.- 15.Molecular diffusion/Alexander Gansen and Jörg Langowski.- PART VII Chromatin transactions and epigenetics.- 16.Fibres/interactions/Christopher J.F. Cameron, James Fraser, Mathieu Blanchette, and Josée Dostie.- 17.DNA replication Sebastian Müller, Dan Filipescu and Geneviève Almouzni.- 18.Development and Epigenetics Nuphar Salts and Eran Meshorer.- 19.Epigenetics and disease/Sanaa Choufani and Rosanna Weksberg.- PART VIII Transcription and RNA metabolism.- 20.Transcription factories/Christopher Eskiw and Jenifer Mitchell.- 21.RNA transport Jonathan Sheinberger and Yaron Shav-Tal.