Molecular Imprinting

Dr. Makoto Komiyama is Assistant Professor of Chemistry at the University of Tokyo. Among his awards is the Chemical Society of Japan Award for Young Chemists. Dr. Komiyama's research interests include cyclodextrin chemistry, functionalized polymer chemistry, and molecular complex chemistry. He received his BA and PhD degrees in chemistry from the University of Tokyo.Makoto Komiyama is the author of Molecular Imprinting: From Fundamentals to Applications, published by Wiley.Takashi Mukawa is the author of Molecular Imprinting: From Fundamentals to Applications, published by Wiley.Hiroyuki Asanuma is the author of Molecular Imprinting: From Fundamentals to Applications, published by Wiley.

"..a clear and detailed description..of interest to graduate students and researchers.."IEEE Electrical Insulation Magazine "...la tercera parte enumera un buen número de aplicaciones...En resumen, la obra es una revisión concisa y didáctica del progreso desarrollado en este campo de la ciencia durante los últimos cinco anos. Por todo ello, el libro aunque desenado inicialmente para graduados, ofrece también un gran interés para los investigadores industriales y con actividad en medois académos.Revista de Plásticos Modernos "...written in an easily understandable fashion that requires only a rudimentary knowledge of chemistry. The book is concise but presents many examples and allows the reader to obtain an understanding of this technology and the future implications without considerable time and effort. It is highly recommended for those interested in learning about an emerging technology that has relevance to chemistry (both synthetic and analytical), polymer science and biology as well as libraries covering these areas of science and technology."Polymer News "The book is very helpful for advanced-course students and researchers, who want to find an overview in this new methodology and to gain valuable hints for their future work."Colloid & Polymer Science "... compact, well-illustrated and excellently written textbook ..."Cellulose Chemistry and Technology(ed. by the Romanian Academy)

• PrefaceINTRODUCTIONImportance of Receptor Molecules in Advanced Science and TechnologyNaturally Ocurring ReceptorsArtificial ReceptorsReceptors for Practical ApplicationsWhy is the Molecular Imprinting Method so Promising?FUNDAMENTALS OF MOLECULAR IMPRINTINGIntroductionGeneral Principle of Molecular ImprintingCovalent Imprinting and Non-covalent ImprintingAdvantages and Disadvantages of Covalent and Non-Covalent ImprintingHistoryEXPERIMENTAL METHODS (I) -PROCEDURES OF MOLECULAR IMPRINTINGIntroductionReagents and Experimental ProceduresCovalent ImprintingNon-covalent Imprinting"Dummy Molecular Imprinting"EXPERIMENTAL METHODS (II) -EVALUATION OF IMPRINTING EFFICIENCYChromatographic ExperimentsBatchwise Guest-Binding ExperimentsDetermination of Guest-Binding ConstantsSPECTROSCOPIC ANATOMY OF MOLECULAR IMPRINTING REACTIONSIntroductionStructures of Adducts in the Pre-organization StepDetermination of the Binding Constant K for the Formation of Monomer-Template AdductRelationship between K Value and Imprinting EfficiencyStructure of the Guest-Binding SiteFLOW-CHART OF A TYPICAL MOLECULAR IMPRINTINGIntroductionChoice of AgentsPolymerizationPacking of Imprinted Polymers into the HPLC ColumnsQuantitative Evaluation of Imprinting EfficiencyAPPLICATIONS OF MOLECULARLY IMPRINTED POLYMERSIntroductionSensor ApplicationsSignaling PolymersMolecularly Imprinted Sorbent AssaysMolecularly Imprinted MembranesAffinity-based Solid-phase ExtractionMolecularly Imprinted CatalystsRECENT CHALLENGES AND PROGRESSIntroductionMolecular Imprinting in WaterUse of Two Kinds of Functional Monomers for Cooperative RecognitionInorganic Gel as the Matrix for Molecular ImprintingArtificial Enzyme (Molecular Catalyst) by Molecular ImprintingCatalytic Antibody Prepared by Using Transition-State AnalogCONCLUSIONS AND PROSPECTSIndex