Phosphodiesterases as Drug Targets

Häftad, Engelska, 2013

Del 204 i serien Handbook of Experimental Pharmacology

3 390 kr

Beställningsvara. Skickas inom 10-15 vardagar. Fri frakt över 249 kr.

Beskrivning

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.

Produktinformation

Utgivningsdatum:2013-11-26
Mått:155 x 235 x 29 mm
Vikt:809 g
Format:Häftad
Språk:Engelska
Serie:Handbook of Experimental Pharmacology
Antal sidor:522
Upplaga:2011
Förlag:Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN:9783642269455

Utforska kategorier

Biokemi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik
Farmakologi inom Medicin

Innehållsförteckning

Phosphodiesterase inhibitors: History of pharmacology; PDE inhibitors: factors that influence potency, selectivity and action; A fission yeast-based platform for phosphodiesterase inhibitor high throughput screening and analyses of phosphodiesterase activity; The pharmacokinetics of PDE inhibitors and the impact of this on their efficacy and the therapeutic window; Structural insight into the substrate specificity of phosphodiesterases;The GAF-tandem domain of phosphodiesterase 5 as a potential drug target; Small molecule allosteric modulators of phosphodiesterase 4; PDE 2 holoenzyme-insights about full length PDE and mechanism of activation by cGMP binding; Harnessing the clinical efficacy of phosphodiesterase 4 inhibitors in inflammatory lung diseases with dual-selective phosphodiesterase inhibitors and novel combination therapies; PDE inhibitors in the treatment of inflammatory diseases; Cyclic nucleotides and phosphodiesterases in monocyte differentiation; PDEs as targets for modulating T cell responses; Role of PDEs in adult-onset pulmonary arterial hypertension; Phosphodiesterases: emerging therapeutic targets for neonatal pulmonary hypertension; Phosphodiesterase inhibition in heart failureEvaluation of the Therapeutic Utility of Phosphodiesterase 5A Inhibition in the mdx MouseModel of Duchenne Muscular Dystrophy; PDEs as targets for intermittent claudication; Treatment of erectile dysfunction and lower urinary tract symptoms by phosphodiesteraseinhibitors; Regulation of endothelial barrier function by cyclic nucleotides: the role of phosphodiesterases; Potential use of PDE inhibitors in treatment of depression and improvement of cognition; PDEs as targets for the treatment of basal ganglia disordersTherapeutic potential of PDE inhibitors in parasitic diseases

Mer från samma författare

Cyclic Nucleotide Phosphodiesterases in Health and Disease

Joseph A. Beavo, Sharron H. Francis, Miles D. Houslay

Häftad, 2019

1 024 kr

Cyclic Nucleotide Phosphodiesterases in Health and Disease

Miles D. Houslay, Sharron H. Francis, Joseph A. Beavo

E-bok

2006

1 204 kr

Cyclic Nucleotide Phosphodiesterases in Health and Disease

Miles D. Houslay, Sharron H. Francis, Joseph A. Beavo

E-bok

2006

1 195 kr

Phosphodiesterases as Drug Targets

Sharron H. Francis, Marco Conti, Miles D. Houslay

Inbunden, 2011

3 390 kr

Phosphodiesterases as Drug Targets

Miles D. Houslay, Marco Conti, Sharron H. Francis

E-bok

2011

4 097 kr

Cyclic Nucleotide Phosphodiesterases in Health and Disease

Joseph A. Beavo, Sharron H. Francis, Miles D. Houslay

Inbunden, 2006

2 998 kr

Mer från samma serie

Del 247

Delta Opioid Receptor Pharmacology and Therapeutic Applications

Emily M. Jutkiewicz

Häftad, 2018

1 307 kr

Del 246

Voltage-gated Sodium Channels: Structure, Function and Channelopathies

Mohamed Chahine

Häftad, 2019

1 702 kr

Del 249

Mechanisms of Drug Resistance in Cancer Therapy

Mario Mandalà, Emanuela Romano

Inbunden, 2019

1 702 kr

Del 251

Brown Adipose Tissue

Alexander Pfeifer, Martin Klingenspor, Stephan Herzig

Inbunden, 2019

2 267 kr

Del 252

New Psychoactive Substances

Hans H. Maurer, Simon D. Brandt

Inbunden, 2019

1 928 kr

Antidepressants

Matthew Macaluso, Sheldon H. Preskorn

Inbunden, 2019

1 702 kr

Sleep-Wake Neurobiology and Pharmacology

Hans-Peter Landolt, Derk-Jan Dijk

Inbunden, 2019

1 702 kr

Del 254

Nociceptin/Orphanin FQ Peptide Receptor

Mei-Chuan Ko, Girolamo Caló

Inbunden, 2019

1 702 kr

Del 254

Nociceptin/Orphanin FQ Peptide Receptor

Mei-Chuan Ko, Girolamo Caló

Häftad, 2020

1 702 kr

Del 255

Calcitonin Gene-Related Peptide (CGRP) Mechanisms

Susan D. Brain, Pierangelo Geppetti

Inbunden, 2019

1 476 kr

Du kanske också är intresserad av

10% rabatt på allt

L'amour toujours : Berättelsen om Tidö

Maggie Strömberg, Torbjörn Nilsson

Inbunden, 2026

275 kr

Cyclic Nucleotide Phosphodiesterases in Health and Disease

Miles D. Houslay, Sharron H. Francis, Joseph A. Beavo

E-bok

2006

1 195 kr

Cyclic Nucleotide Phosphodiesterases in Health and Disease

Joseph A. Beavo, Sharron H. Francis, Miles D. Houslay

Inbunden, 2006

2 998 kr

Cyclic Nucleotide Phosphodiesterases in Health and Disease

Miles D. Houslay, Sharron H. Francis, Joseph A. Beavo

E-bok

2006

1 204 kr

Phosphodiesterases as Drug Targets

Miles D. Houslay, Marco Conti, Sharron H. Francis

E-bok

2011

4 097 kr

Cyclic Nucleotide Phosphodiesterases in Health and Disease

Joseph A. Beavo, Sharron H. Francis, Miles D. Houslay

Häftad, 2019

1 024 kr

Phosphodiesterases as Drug Targets

Sharron H. Francis, Marco Conti, Miles D. Houslay

Inbunden, 2011

3 390 kr

1–2 Kings, 1–2 Chronicles, Ezra, Nehemiah, Esther

Marco Conti, Thomas C. Oden, Marco Conti, Thomas C. Oden, Thomas C Oden

Inbunden, 2008

493 kr

Mobile Ad Hoc Networking

Ivan Stojmenovic, Silvia Giordano, Marco Conti, Stefano Basagni

E-bok

2013

2 184 kr

Job – Volume 6

Manlio Simonetti, Marco Conti

Inbunden, 2006

493 kr

Phosphodiesterases as Drug Targets

AvSharron H. Francis,Marco Conti

Häftad, Engelska, 2013

Del 204 i serien Handbook of Experimental Pharmacology

3 390 kr

Beställningsvara. Skickas inom 10-15 vardagar. Fri frakt över 249 kr.

Beskrivning

Produktinformation

Utgivningsdatum:2013-11-26
Mått:155 x 235 x 29 mm
Vikt:809 g
Format:Häftad
Språk:Engelska
Serie:Handbook of Experimental Pharmacology
Antal sidor:522
Upplaga:2011
Förlag:Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN:9783642269455

Utforska kategorier

Biokemi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik
Farmakologi inom Medicin

Innehållsförteckning

Phosphodiesterase inhibitors: History of pharmacology; PDE inhibitors: factors that influence potency, selectivity and action; A fission yeast-based platform for phosphodiesterase inhibitor high throughput screening and analyses of phosphodiesterase activity; The pharmacokinetics of PDE inhibitors and the impact of this on their efficacy and the therapeutic window; Structural insight into the substrate specificity of phosphodiesterases;The GAF-tandem domain of phosphodiesterase 5 as a potential drug target; Small molecule allosteric modulators of phosphodiesterase 4; PDE 2 holoenzyme-insights about full length PDE and mechanism of activation by cGMP binding; Harnessing the clinical efficacy of phosphodiesterase 4 inhibitors in inflammatory lung diseases with dual-selective phosphodiesterase inhibitors and novel combination therapies; PDE inhibitors in the treatment of inflammatory diseases; Cyclic nucleotides and phosphodiesterases in monocyte differentiation; PDEs as targets for modulating T cell responses; Role of PDEs in adult-onset pulmonary arterial hypertension; Phosphodiesterases: emerging therapeutic targets for neonatal pulmonary hypertension; Phosphodiesterase inhibition in heart failureEvaluation of the Therapeutic Utility of Phosphodiesterase 5A Inhibition in the mdx MouseModel of Duchenne Muscular Dystrophy; PDEs as targets for intermittent claudication; Treatment of erectile dysfunction and lower urinary tract symptoms by phosphodiesteraseinhibitors; Regulation of endothelial barrier function by cyclic nucleotides: the role of phosphodiesterases; Potential use of PDE inhibitors in treatment of depression and improvement of cognition; PDEs as targets for the treatment of basal ganglia disordersTherapeutic potential of PDE inhibitors in parasitic diseases