Pharmacokinetic Challenges in Drug Discovery

Häftad, Engelska, 2012

Del i serien Ernst Schering Foundation Symposium Proceedings

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Beskrivning

The Pharmaceutical industry is therefore focussing on ways to reduce attrition by addressing frequent reasons for clinical drug failures very early in the drug discovery process.

Produktinformation

Utgivningsdatum:2012-12-16
Mått:148 x 210 x 18 mm
Vikt:421 g
Format:Häftad
Språk:Engelska
Serie:Ernst Schering Foundation Symposium Proceedings
Antal sidor:306
Förlag:Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN:9783662043851

Utforska kategorier

Biokemi inom Naturvetenskap och teknik
Farmakologi inom Medicin

Innehållsförteckning

1 Accelerating the Process of Drug Discovery.- 2 The Role of Pharmacokinetics in Drug Discovery: Finding Drug Candidates with the Greatest Potential for Success.- 3 Rapid Permeability Screening in Drug Discovery to Predict Human Intestinal Absorption.- 4 Drug Metabolism Assays and Their Use in Drug Discovery.- 5 Prediction of Human Pharmacokinetics Based on Preclinical In Vitro and In Vivo Data.- 6 In Vitro Screening of Cytochrome P450 Induction Potential.- 7 Drug Transport Across the Blood—Brain Barrier.- 8 The Development and Implementation of Bioanalytical Methods Using LC-MS to Support ADME Studies in Early Drug Discovery and Candidate Selection.- 9 Strategies in Lead Selection and Optimization: Application of a Graphical Model and Automated In Vitro ADME Screening.- 10 High-Throughput Screening — Brains Versus Brawn.- 11 Relation of Molecular Properties with Drug Absorption and Disposition.- 12 Modelling Human Cytochrome P450-Substrate Interactions.- 13 Forum Discussion.- Previous Volumes Published in This Series.