Emerging concepts of pain therapy based on neuronal mechanisms.- The pharmacology of nociceptor priming.- Sodium channels and pain.- Role of nerve growth factor in pain.- Central sensitization in humans – assessment and pharmacology.- The role of NO in the spinal cord.- The role of the endocannabinoid system in pain.- The role of glia in the spinal cord in neuropathic and inflammatory pain.- Plasticity of inhibition in the spinal cord.- Gene regulation in nociception. Modulation of peripheral inflammation by the spinal cord.- The relationship between opioids and cytokines in the spinal cord.- The role of proteases in pain. Pain-related pharmacology in the amygdala.- Pain and itch – differences and commonalities.