Narratives and Comparisons – Adversaries or Allies in Understanding Science?
Martin Carrier, Rebecca Mertens, Carsten Reinhardt, Martin Carrier, Rebecca Mertens
Häftad, 2021
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Construction of Analogy–Based Research Progr – The Lock–and–Key Analogy in 20th Century Biochemistry
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Beskrivning
When the German chemist Emil Fischer presented his lock-and-key hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity.Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling.
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