Etiology and Morphogenesis of Congenital Heart Disease

From Gene Function and Cellular Interaction to Morphology

AvToshio Nakanishi,Roger R. Markwald

Häftad, Engelska, 2018

555 kr

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Beskrivning

This volume focuses on the etiology and morphogenesis of congenitalheart diseases.

Produktinformation

Utgivningsdatum:2018-06-07
Mått:155 x 235 x 20 mm
Vikt:670 g
Format:Häftad
Språk:Engelska
Antal sidor:383
Förlag:Springer Verlag, Japan
ISBN:9784431566335

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Innehållsförteckning

PartI. From Molecular Mechanism to Intervention for Congenital Heart Diseases, Nowand Future .- Reprogramming Approaches toCardiovascular Disease: From Developmental Biology to Regenerative Medicine.- The arterial epicardium, a developmental approach to cardiac diseaseand repair.- Cell sheet tissue engineering for heart failure.- Future treatment of heart failure and pathophysiological analysis ofvarious heart diseases using human iPS cell-derived cardiomyocytes.- Congenital heart disease: in search of remedial etiologies.- Part II. Left-Right Axis andHeterotaxy Syndrome.- Left-rightAsymmetry and Human Heterotaxy Syndrome.- Roles of motileand immotile cilia in left-right symmetry breaking.- Role of ciliaand left-right patterning in congenital heart disease.- Pulmonaryarterial hypertension in patients with heterotaxy /polysplenia syndrome.- Part III. Cardiomyocyte and MyocardialDevelopment.- Single Cell Expression Analyses ofEmbryonic Cardiac Progenitor Cells.- Meis1 Regulates Post-Natal CardiomyocyteCell Cycle Arrest.- Intercellular signalling in cardiac development anddisease: NOTCH.- The epicardium in ventricular septation during evolutionand development.- S1P-S1p2 signaling in cardiac precursor cells migration.- Myogenic progenitor cell differentiation is dependent on modulation ofmitochondrial biogenesis through autophagy.- The role of thethyroid in the developing heart.-Part IV. Valve Development and Diseases.- Atrioventricular valve abnormalities: From molecular mechanismsunderlying morphogenesis to clinical perspective.- MolecularMechanisms of Heart Valve Development and Disease.- A novel role forendocardium in perinatal valve development: Lessons learned from tissuespecific gene deletion of the Tie1 receptor tyrosine kinase.- The Role of the Epicardium in the Formation of the Cardiac Valves inthe Mouse.- TMEM100, a novel intracellular transmembrane proteinessential for vascular development and cardiac morphogenesis.- Cell autonomous regulation of BMP-2 in endocardial cushion cells duringAV valvuloseptal morphogenesis.-Part V. The Second Heart Field and Outflow Tract.- Properties of cardiac progenitor cells in the second heart field.- Nodal signaling and congenital heart defects.- UtilizingZebrafish to Understand Second Heart Field Development.- A history andinteraction of outflow progenitor cells implicated in “Takao syndrome”.- The loss of Foxc2 expression in the outflow tract links the interruptedarch in the conditional Foxc2 knockout mouse.- Environmentalmodification for phenotype of truncus arteriosus in Tbx1 hypomorphic mice.- Part VI. Vascular Development andDiseases.- Extracellular matrix remodeling invascular development and disease.- The “cardiac neural crest” conceptrevisited.- Roles of endothelial Hrt genes for vascular development.- Placental Expression of Type 1 and 3 Inositol Trisphosphate Receptorsis Required for the Extra-embryonic Vascular Development.- Tissue Remodeling in Vascular Wall in Kawasaki Disease-relatedVasculitis Model Mice.- PartVII. Ductus Arteriosus.- Progerinexpression during normal closure of the human ductus arteriosus: A case ofpremature ageing?.- The multiple roles of prostaglandin E2 in the regulation ofthe ductus arteriosus.- Developmental Differences in the Maturation of SarcoplasmicReticulum and Contractile Proteins in Large Blood Vessels Influences TheirContractility.- Fetal and Neonatal Ductus Arteriosus is Regulated withATP-sensitive Potassium Channel.-Part VIII. Conduction System and Arrhythmia.- Regulation of vertebrate conduction system development.- Cardiac Pacemaker Development from a Tertiary Heart Field.- Endothelin receptor type A expressing cell population in the inflowtract contributes to chamber formation.- Specific isolation of HCN4 positivecardiac pace-making cells derived from embryonic stem cell.- Part IX. Current Molecular Mechanismin Cardiovascular Development.- Combinatorialfunctions of transcription factorsand epigenetic factors in heart developmentand disease.- Pcgf5 contributes to PRC1 (Polycomb repressive complex 1)in developing cardiac cells.-non-coding RNAs in cardiovascular disease.- Part X. iPS Cells and Regeneration inCongenital Heart Diseases.- Humanpluripotent stem cells to model congenital heart disease.- Engineered cardiac tissues generated from immature cardiac andstem-cell derived cells: Multiple approaches and outcomes.- Dissecting the left heart hypoplasia by pluripotent stem cells.- Lentiviral gene transfer to iPS cells; toward the cardiomyocytedifferentiation of Pompe disease-specific iPS cells.- Molecularanalysis of long-term cultured cardiac stem cells for cardiac regeneration.- Epicardial contribution in neonatal heart regeneration.- Part XI. Current Genetics inCongenital Heart Diseases.- Geneticdiscovery for congenital heart defects.- Evidence that deletion of ETS-1, agene in the Jacobsen syndrome (11q-) cardiac critical region, causes congenitalheart defects through impaired cardiac neural crest cell function.- Notch signaling in aortic valve development and disease.- To detect and explore mechanism of CITED2 mutation and methylation inchildren with congenital heart disease.