Bradley B. Keller - Böcker

This book is a unique overview of cardiovascular development from the cellular to the organ level across a broad range of species. The first section focuses on the molecular, cellular, and integrative mechanisms that determine cardiovascular development. The second section has eight chapters that summarise cardiovascular development in invertebrate and vertebrate systems. The third section discusses the effects of disease and environmental and morphogenetic influences on non-mammalian and mammalian cardiovascular development. It includes strategies for the management of congenital cardiovascular malformations in utero and postnatally. The book will interest graduate students and researchers who work in the fields of developmental biology, physiology, and molecular and paediatric cardiology.

This volume focuses on the etiology and morphogenesis of congenitalheart diseases. It reviews in detail the early development and differentiation ofthe heart, and later morphologic events of the cardiovascular system, coveringa wide range of topics such as gene functions, growth factors, transcriptionfactors and cellular interactions that are implicated in cardiac morphogenesisand congenital heart disease. This book also presents recent advances in stemcell and cell sheet tissue engineering technologies which have the potential toprovide novel in vitro disease models and to generate regenerative paradigmsfor cardiac repair and regeneration.   Thisis the ideal resource for physician scientists and investigators looking forupdates on recent investigations on the origins of congenital heart disease andpotential future therapies.