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Beskrivning
Combinatorial chemistry and molecular diversity approaches to scientific inquiry and novel product R&D have exploded in the 1990s! Within each section chapters are prepared by experts in the field, including, for example, in Section I: Coverage of mixture pools vs.
Section I: Combinatorial Chemistry.- Combinatorial chemistry: A perspective.- Techniques for mixture synthesis.- Techniques for single-compound synthesis.- Recent advances in solid-phase synthesis.- Selection of supports for solid-phase organic synthesis.- Solution-phase combinatorial chemistry.- Analytical methods for the quality control of combinatorial libraries.- Automated synthesis.- Applications of combinatorial technology to drug discovery.- Section II: Combinatorial Biology and Evolution.- Combinatorial biology and evolution: A perspective.- Models and search strategies for applied molecular evolution.- Molecular evolutionary biology.- Landscapes for molecular evolution: Lessons from in vitro selection experiments with nucleic acids.- Synthetic peptide libraries.- Phage display.- Section III: Informatics and Related Topics.- Informatics and related topics: A perspective.- Modern chemical and biological databases.- Practical high throughput screening.- Deconvolution methods in solid-phase synthesis.- Patent strategies in molecular diversity.- Combinatorial chemistry alliances in the 1990s: Review of deal structures.- Combinatorial chemistry: The promise fulfilled?.- A compendium of solid-phase chemistry publications.- Author Index.