Molecular Recognition of DNA Double Helix

Dr. Abhijit SAHAInstitut Curie, Campus Universitaire, Orsay, France

• 1. Overview of DNA minor groove binding synthetic small molecules and photochemistry of BrU substituted DNA.- 2. Synthesis and Biological Evaluation of Targeted Transcriptional Activator with HDAC8 Inhibitory Activity.- 3. Chemical Modification of a Synthetic Small Molecule Boosts its Biological Efficacy against Pluripotency Genes in Mouse Fibroblast.- 4. Development of a novel photochemical detection technique for the analysis of polyamide binding sites.- 5. Examining cooperative binding of Sox2 on DC5 regulatory element upon complex formation with Pax6 through excess electron transfer assay.- 6.UVA irradiation of BrU-substituted DNA in the presence of Hoechst 33258.