Ganglioside Biochemistry

Prof. Cheorl-Ho KimMolecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University

• Preface: Carbohydrates- the third life chain.- 1. Glycosylation.- 2. N-Glycan and O-glycan glycosylation in eukaryotes.- 3. Sialyltransferase, sialylation and sulfoylation.- 4. Congenital disorders of glycosylation (CDG) of N-glycoprotein.- 5. Neuraminic acids/sialic acids (N-acetyl- and N-glycolylneuraminic acid).- 6. Biosynthesis of sialic acid.- 7. Neu5Gc (N-glycolylneuraminic acid).- 8. Gangliosides.- 9. Gangliosides and tumor-associated ganglioside (TAG) modulate receptor-tyrosine kinases (RTKs).- 10. Sialic acids and TAGs of tumor cells to escape immunesurveillance and immuneediting.- 11. Tumor characteristics in tumor related carbohydrates.