Biomedical Nanosensors

Joseph Irudayaraj is Professor of Biological Engineering at Purdue University. Dr. Irudayaraj is also a Co-Director of the Physiological Sensing Facility (PSF) and a member of the Biophysics Core at Bindley and has authored over 150 refereed publications.

"Biomedical nanosensors have a wide range of applications in human, animal, and plant health for diagnostics and therapeutics. Assembled by Prof. Joseph Irudayaraj, this book is an important reference in the exciting, important, and rapidly evolving field of biomedical nanotechnology. The chapters are detailed and thorough, and rich with references. It is an interdisciplinary collection of contributions from experts with diverse backgrounds, and therefore a very interesting and educational read for students and faculty researchers in bionanotechnology."—Prof. Rashid Bashir - University of Illinois at Urbana-Champaign, USAThis book gives an inspirational overview on current developments in nanomaterial and nanoarchitecture for advanced sensing applications in the fields of medical diagnostics and therapeutics agents for drug delivery. It focuses on the nanoscale perspective of materials properties towards new sensing strategies to study the biological systems with improved sensitivity, to characterize molecular interaction and cellular mechanisms at molecular or cellular dimension. The content is comprehensive and rich in references covering the topics on fundamental biosensor design, natural and synthetic biorecognition elements, inorganic nanomaterials such as gold nanoparticles and carbon nanotube-based sensors, engineered nanoparticles for drug delivery, and nanoarchitecture and nanodevices towards implantable sensing. Each chapter is provided with a clear and brief introduction, the sub-topics are well organized and easy to follow, and summarized with a prospective and future outlook. . . . I am very impressed by the concise and informative content of this . . . very useful reference work for research scientists working in the field of nanotechnology, as well as high school teachers and university students to get an overview on the topic of biomedical nanosensors."—Dr. W. C. Mak, Biosensors and Bioelectronics Centre, Department of Physics, Chemistry and Biology, Linköping University, Sweden

• Dyneins: Ancient Protein Complexes Gradually Reveal Their Secrets. Two Decades of Cytoplasmic Dynein: From Fast to Forceful. Functional Analysis of the Dynein Motor Domain. Structural Studies on the Dynein Heavy Chain. Structural Analysis of Microtubule-Bound Dynein. The Dynein Stalk: Atomic Structure and Roles in the Mechanism of the Dynein Motor. Enzymatic and Motile Properties of Native Dynein Molecules. Motile Properties of Cytoplasmic Dynein. Motile Properties of Inner Arm Dynein. Dynein Motility in Cilia and Flagella. 3D Structures of Axonemes. Functional Diversity of Axonemal Dyneins. Assembly and Regulation of Dynein Light Chains. Regulatory Subunits of Axonemal Dynein. The Role of Dynein in Yeast Nuclear Segregation.