Brain Diseases and Metalloproteins

"This is an authoritative and thorough overview of a field of growing significance to neuroscience. Metal ion metabolism is intimately involved with the causes of most neurodegenerative disease, and is an area of unexploited importance for potential drug development. This work is timely, and tremendously useful with an excellent choice of subjects, beautifully and rigorously presented"—Prof. Ashley I. Bush - University of Melbourne, Australia

• 1. Introduction, 2. A Possible Key Role for Redox-Active Metal Ions and Soluble Oligomers in Neurodegenerative Disease, 3. Modelling of the Metal Binding Sites in Proteins Involved in Neurodegeneration, 4. Mammalian Metallothioneins, 5. Copper Transporting P-Type ATPases in the Brain, 6. Role of the Amyloid Precursor Protein and Copper in Alzheimer’s Disease, 7. Role of Aluminum and Other Metal Ions in the Pathogenesis of Alzheimer’s Disease, 8. Prion Diseases, Metals and Antioxidants, 9. Emerging Role for Copper-Bound ?-Synuclein in Parkinson’s Disease Etiology, 10. Interactions of ?-Synuclein with Metal Ions: New Insights into the Structural Biology and Bioinorganic Chemistry of Parkinson’s Disease, 11. An Attempt to Treat Amyotrophic Lateral Sclerosis by Intracellular Copper Modification Using Ammonium Tetrathiomolybdate and/or Metallothionein: Fundamentals and Perspective, Index