Rare Earth Elements in Human and Environmental Health

Giovanni Pagano has 40 years’ experience in environmental research, including projects supported by grants from the European Commission and the North Atlantic Treaty Organization. He has been a senior scientist at the Italian National Cancer Institute in Naples, Italy, and a contractor scientist at the University of Naples Federico II, Italy. He is a visiting professor in various universities of France, Greece, and Croatia. Prof. Pagano has published 105 journal articles and 22 book chapters, with 1900 ResearchGate citations.

"Rare earth elements are involved in a number of essential technological applications. Their effects raise a number of challenges in environmental sciences and in human health. The present book provides an extensive and balanced survey of the manifold—adverse and favorable—effects associated with rare earth elements."—Prof. Dr. José L. Domingo, Rovira i Virgili University, Spain"The present book is a valuable tool to gain insight into the complex and sometimes surprising health effects of rare earth elements. Especially interesting—due to my field of research—are the chapters addressed to the study of the changes in redox endpoints in a number of organisms and cell systems. This carefully edited book, with a multidisciplinary view of rare earth elements, is really an important scientific contribution." —Prof. Dr. Federico V. Pallardó, University of Valencia, Spain"I congratulate the authors for this timely production of an extensive overview of an important topic in environmental and medical sciences: the risks and challenges that may be connected with increasing use and distribution of rare earth elements. It is essential to increase our knowledge about the environmental fate and biological effects of these technologically so important metals in order to prevent unforeseen long-term consequences of our doing. This book will surely become an important resource for scientists, engineers, and decision makers who understand the need of a sensible exploitation of this resource." —Prof. Dr. Susanne Heise, Hamburg University of Applied Sciences, Germany

• Trends in Occupational Toxicology of Rare Earth Elements. Levels and Biodistribution of Rare Earths in Human Tissues. Rare Earth Elements, Oxidative Stress and Disease. Cerium Oxide Nanoparticles-associated Oxidant and Antioxidant Effects and Mechanism. Rare Earth Elements and Plants. Rare Earth Elements and Microorganisms. Rare Earth Element Toxicity to Marine and Freshwater Algae. Exposure to Rare Earth Elements in Animals: a Systematic Review of Biological Effects in Mammals, Fish and Invertebrates. Hazard Assessment and the Evaluation of Rare Earth Element Dose-Response Relationships. Rare earth elements as phosphate binders: From kidneys to lakes. Rare Earth Elements: Modulation of Calcium-Driven Processes in Epithelium and Stroma. Rare Earth Elements Equilibria in Aqueous Media. Conclusions and Research Priorities.