Pengfei Shi is the dean of Medical and Health Care Featured College, head of the Precision Tumor Diagnosis and Treatment Engineering Research Center for Nuclear Drugs in Higher Education Institutions in Shandong Province, leader of the Shandong Province Youth Innovation and Training Team, outstanding graduate supervisor in Shandong Province, and young editorial board member of Tungsten journal. Her research mainly focuses on the design and synthesis of nanofunctional materials and their applications in tumor diagnosis and treatment. Till now, she has hosted 2 National Natural Science Foundation of China projects and 7 provincial projects, published over 40 SCI papers, participated in the compilation of 2 monographs, and was granted 6 national invention patents.Huairong Zhang is a doctoral supervisor. Zhang focus on studying the tracing of gene-like functional molecules at the single-cell level, the construction and application of intelligent response nanomedicine carriers, the research on multi-signal recognition biosensors and integrated diagnosis and treatment, and the analysis of single particles and single cells. Till now, she has hosted 2 National Natural Science Foundation of China projects and 2 provincial research projects, published over 30 SCI papers and participated in the compilation of 2 monographs. Lei Yang is the head of the Shandong Province Youth Innovation Team, an outstanding graduate student advisor at Linyi University, and the program leader for the Health Inspection and Quarantine major. His primary research focuses on the development of fluorescent probes and their applications in disease diagnosis and treatment. He has led one National Natural Science Foundation of China project and two provincial/ministerial-level research projects. As the first author or corresponding author, he has published 34 SCI-indexed papers, obtained 1 authorized national invention patent, and contributed to 2 academic monographs.Shujuan Sun graduated from Fuzhou University in 2021 and joined the Institute of Biochemical Analysis at Linyi University in 2022. Her research focuses on the application of nucleic acid nanomaterials in tumor diagnosis and treatment, demonstrating strong research capabilities. She has led a project funded by the Natural Science Foundation of Shandong Province, achieving promising phased results in addressing key scientific challenges in this field, while also supervising a provincial-level undergraduate innovation and entrepreneurship training program. Additionally, she has published over ten SCI-indexed papers and obtained 1 national invention patent.Shusheng Zhang is a doctoral supervisor. He was granted an academician of the European Academy of Natural Sciences, the head of the innovation team of biochemical analysis, the distinguished professor of the Mount Taishan Scholar Program, the winner of the National Science Fund for Distinguished Young Scholars, and the young and middle-aged experts with outstanding contributions to the National Hundred, Thousand and Ten Thousand Talent Project. His research focuses on the biochemical analysis. Till now, he has presided over 10 National Natural Science General Projects and 7 provincial projects. He has published over 100 SCI papers with an impact factor greater than 5.0, 1 English monograph, and 7 Chinese monographs.

• Chapter 1 Application of Self-assembled DNA Nanomaterials in Tumor Diagnosis and Treatment.- Chapter 2 Application of Small Molecule Fluorescent Probe in Tumor Diagnosis and Treatment.- Chapter 3 Application of Metal-Organic Frameworks Materials in Tumor Diagnosis and Treatment.- Chapter 4 Application of Nano-drug Carrier in Tumor Diagnosis and Treatment.- Chapter 5 Toxicological analysis of nanomaterials for tumor diagnosis and treatment.

Pengfei Shi is the dean of Medical and Health Care Featured College, head of the Precision Tumor Diagnosis and Treatment Engineering Research Center for Nuclear Drugs in Higher Education Institutions in Shandong Province, leader of the Shandong Province Youth Innovation and Training Team, outstanding graduate supervisor in Shandong Province, and young editorial board member of Tungsten journal. Her research mainly focuses on the design and synthesis of nanofunctional materials and their applications in tumor diagnosis and treatment. Till now, she has hosted 2 National Natural Science Foundation of China projects and 7 provincial projects, published over 40 SCI papers, participated in the compilation of 2 monographs, and was granted 6 national invention patents.Huairong Zhang is a doctoral supervisor. Zhang focus on studying the tracing of gene-like functional molecules at the single-cell level, the construction and application of intelligent response nanomedicine carriers, the research on multi-signal recognition biosensors and integrated diagnosis and treatment, and the analysis of single particles and single cells. Till now, she has hosted 2 National Natural Science Foundation of China projects and 2 provincial research projects, published over 30 SCI papers and participated in the compilation of 2 monographs. Lei Yang is the head of the Shandong Province Youth Innovation Team, an outstanding graduate student advisor at Linyi University, and the program leader for the Health Inspection and Quarantine major. His primary research focuses on the development of fluorescent probes and their applications in disease diagnosis and treatment. He has led one National Natural Science Foundation of China project and two provincial/ministerial-level research projects. As the first author or corresponding author, he has published 34 SCI-indexed papers, obtained 1 authorized national invention patent, and contributed to 2 academic monographs.Shujuan Sun graduated from Fuzhou University in 2021 and joined the Institute of Biochemical Analysis at Linyi University in 2022. Her research focuses on the application of nucleic acid nanomaterials in tumor diagnosis and treatment, demonstrating strong research capabilities. She has led a project funded by the Natural Science Foundation of Shandong Province, achieving promising phased results in addressing key scientific challenges in this field, while also supervising a provincial-level undergraduate innovation and entrepreneurship training program. Additionally, she has published over ten SCI-indexed papers and obtained 1 national invention patent.Shusheng Zhang is a doctoral supervisor. He was granted an academician of the European Academy of Natural Sciences, the head of the innovation team of biochemical analysis, the distinguished professor of the Mount Taishan Scholar Program, the winner of the National Science Fund for Distinguished Young Scholars, and the young and middle-aged experts with outstanding contributions to the National Hundred, Thousand and Ten Thousand Talent Project. His research focuses on the biochemical analysis. Till now, he has presided over 10 National Natural Science General Projects and 7 provincial projects. He has published over 100 SCI papers with an impact factor greater than 5.0, 1 English monograph, and 7 Chinese monographs.

• Chapter 1 Application of Self-assembled DNA Nanomaterials in Tumor Diagnosis and Treatment.- Chapter 2 Application of Small Molecule Fluorescent Probe in Tumor Diagnosis and Treatment.- Chapter 3 Application of Metal-Organic Frameworks Materials in Tumor Diagnosis and Treatment.- Chapter 4 Application of Nano-drug Carrier in Tumor Diagnosis and Treatment.- Chapter 5 Toxicological analysis of nanomaterials for tumor diagnosis and treatment.

Pengfei Shi is the dean of Medical and Health Care Featured College, head of the Precision Tumor Diagnosis and Treatment Engineering Research Center for Nuclear Drugs in Higher Education Institutions in Shandong Province, leader of the Shandong Province Youth Innovation and Training Team, outstanding graduate supervisor in Shandong Province, and young editorial board member of Tungsten journal. Her research mainly focuses on the design and synthesis of nanofunctional materials and their applications in tumor diagnosis and treatment. Till now, she has hosted 2 National Natural Science Foundation of China projects and 7 provincial projects, published over 40 SCI papers, participated in the compilation of 2 monographs, and was granted 6 national invention patents.Huairong Zhang is a doctoral supervisor. Zhang focus on studying the tracing of gene-like functional molecules at the single-cell level, the construction and application of intelligent response nanomedicine carriers, the research on multi-signal recognition biosensors and integrated diagnosis and treatment, and the analysis of single particles and single cells. Till now, she has hosted 2 National Natural Science Foundation of China projects and 2 provincial research projects, published over 30 SCI papers and participated in the compilation of 2 monographs. Lei Yang is the head of the Shandong Province Youth Innovation Team, an outstanding graduate student advisor at Linyi University, and the program leader for the Health Inspection and Quarantine major. His primary research focuses on the development of fluorescent probes and their applications in disease diagnosis and treatment. He has led one National Natural Science Foundation of China project and two provincial/ministerial-level research projects. As the first author or corresponding author, he has published 34 SCI-indexed papers, obtained 1 authorized national invention patent, and contributed to 2 academic monographs.Shujuan Sun graduated from Fuzhou University in 2021 and joined the Institute of Biochemical Analysis at Linyi University in 2022. Her research focuses on the application of nucleic acid nanomaterials in tumor diagnosis and treatment, demonstrating strong research capabilities. She has led a project funded by the Natural Science Foundation of Shandong Province, achieving promising phased results in addressing key scientific challenges in this field, while also supervising a provincial-level undergraduate innovation and entrepreneurship training program. Additionally, she has published over ten SCI-indexed papers and obtained 1 national invention patent.Shusheng Zhang is a doctoral supervisor. He was granted an academician of the European Academy of Natural Sciences, the head of the innovation team of biochemical analysis, the distinguished professor of the Mount Taishan Scholar Program, the winner of the National Science Fund for Distinguished Young Scholars, and the young and middle-aged experts with outstanding contributions to the National Hundred, Thousand and Ten Thousand Talent Project. His research focuses on the biochemical analysis. Till now, he has presided over 10 National Natural Science General Projects and 7 provincial projects. He has published over 100 SCI papers with an impact factor greater than 5.0, 1 English monograph, and 7 Chinese monographs.

• Chapter 1 Application of Self-assembled DNA Nanomaterials in Tumor Diagnosis and Treatment.- Chapter 2 Application of Small Molecule Fluorescent Probe in Tumor Diagnosis and Treatment.- Chapter 3 Application of Metal-Organic Frameworks Materials in Tumor Diagnosis and Treatment.- Chapter 4 Application of Nano-drug Carrier in Tumor Diagnosis and Treatment.- Chapter 5 Toxicological analysis of nanomaterials for tumor diagnosis and treatment.