Basic Immunology and Its Clinical Application

Mitsuru Matsumoto, MD, PhD, was a Professor of Molecular Immunology at the Institute for Enzyme Research at Tokushima University, Japan, and has been a Professor Emeritus at Tokushima University since 2023. He completed his MD, PhD at Ehime University, School of Medicine. His fields of study include immunology, internal medicine, and genetics engineering. His research focuses on the molecular pathogenesis of autoimmune disease.

• Part I. From the Bench to the Bedside.- 1. Novel Insights into the Autoimmunity from the Genetic Approach of the Human Disease.- 2. Learning the Autoimmune Pathogenesis through the Study of Aire.- 3. Extrathymic AIRE expressing cells: a historical perspective.- 4. Autoimmunity Associated with the Misfolded Proteins Complexed with MHC Class II Molecules.- 5. Regulatory T cells for the Control of Autoimmunity.- 6. Autoinflammatory Diseases of Men and Mice.- 7. Nucleoside-Sensing Toll-Like Receptors as Therapeutic Targets for Autoimmune Diseases.- Part II.Manipulating the Immune System.- 8. Development and Function of New Subsets of Innate-Like Lymphocytes and Innate Lymphoid Cells.- 9. The Molecular Mechanisms and the Functions of New Types of Regulated Cell Death.- 10. RNA Metabolism Controls Immune Function.- Part III Coopting with Microorganisms.- 11. Development of Orally Ingestible IgA Antibody Drugs to Maintain Symbiosis between Humans and Microorganisms.- 12. TCR Signals Controlling Both Toxoplasmosis and Cancer.- Part IV. Novel Methodologies for the New Era of Immunology.- 13. Imaging of the CAR-T Cells.- 14. Development of T-cell Therapy from Multipotent Stem Cell.- 15. Genetic and Epigenetic Control of Immune Cells.- 16. HLA Genetics for the Human Diseases.