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THE SUNDAY TIMES AND NEW YORK TIMES BESTSELLERThis enthralling novel, inspired by the 2006 film, illustrates that fantasy is the sharpest tool to explore the terrors and miracles of the human heartYou shouldn't come in here. You could get lost. It has happened before. I'll tell you the story one day, if you want to hear it. In fairy tales, there are men and there are wolves, there are beasts and dead parents, there are girls and forests. Ofelia knows all this, like any young woman with a head full of stories. And she sees right away what the Capitán is, in his immaculate uniform, boots and gloves, smiling: a wolf.But nothing can prepare her for the fevered reality of the Capitán’s eerie house, in the midst of a dense forest which conceals many things: half-remembered stories of lost babies; renegade resistance fighters hiding from the army; a labyrinth; beasts and fairies.There is no one to keep Ofelia safe as the labyrinth beckons her into her own story, where the monstrous and the human are inextricable, where myths pulse with living blood ...

The International Symposium on Dynamics of Vehicles on Roads and Tracks is the leading international gathering of scientists and engineers from academia and industry in the field of ground vehicle dynamics to present and exchange their latest innovations and breakthroughs. Established in Vienna in 1977, the International Association of Vehicle System Dynamics (IAVSD) has since held its biennial symposia throughout Europe and in the USA, Canada, Japan, South Africa and China. The main objectives of IAVSD are to promote the development of the science of vehicle dynamics and to encourage engineering applications of this field of science, to inform scientists and engineers on the current state-of-the-art in the field of vehicle dynamics and to broaden contacts among persons and organisations of the various countries engaged in scientific research and development in the field of vehicle dynamics and related areas.IAVSD 2017, the 25th Symposium of the International Association of Vehicle System Dynamics was hosted by the Centre for Railway Engineering at Central Queensland University, Rockhampton, Australia in August 2017. The symposium focused on the following topics related to road and rail vehicles and trains: dynamics and stability; vibration and comfort; suspension; steering; traction and braking; active safety systems; advanced driver assistance systems; autonomous road and rail vehicles; adhesion and friction; wheel-rail contact; tyre-road interaction; aerodynamics and crosswind; pantograph-catenary dynamics; modelling and simulation; driver-vehicle interaction; field and laboratory testing; vehicle control and mechatronics; performance and optimization; instrumentation and condition monitoring; and environmental considerations. Providing a comprehensive review of the latest innovative developments and practical applications in road and rail vehicle dynamics, the 213 papers now published in these proceedings will contribute greatly to a better understanding of related problems and will serve as a reference for researchers and engineers active in this specialised field. Volume 2 contains 135 papers under the subject heading Rail.

Cytosol, the liquid found inside cells, is the site for multiple cell processes, including signaling from the cell membrane to sites within the cell. Cytosolic signaling mechanisms are researched and studied in graduate programs in cell biology, molecular biology, biochemistry, pharmacology, molecular and cellular physiology, pharmacy, and biomedical sciences. Articles written and edited by experts in the field Thematic volume covering material needed for young professionals joining the field of research and graduate students taking survey courses Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more.

Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry.

For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic level Edited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development

Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences.

Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics Features important commonalities and differences among retroviral systems

**Selected for 2026 Doody's Core Titles in Molecular Biology**Diagnostic Molecular Biology, Second Edition provides an up-to-date comprehensive overview of the latest advances in molecular diagnostics and the fundamental molecular aspects in this area. The book delves into the essential principles behind the transmission and expression of genetic information, including nucleic acids, proteins, and chromosomes, specifically their genome structure, life cycle, and evolution. The latest methods and instrumentation in the field are examined with detailed procedures and explanations provided for each technique. A range of techniques are also investigated, such as those used in sequencing analysis, genome and transcriptome analysis, and nucleic acid amplitification techniques. This book covers the collection, isolation, and purification of DNA, RNA, and protein from different sources. Additionally, discussion on the applications of next-generation sequencing (NGS) and the role of NGS in the future of precision medicine is included. The book also examines the use of molecular diagnostics for chromosomal disorders, inherited diseases, and infectious diseases. Moreover, this new edition features recent advances in the detection of respiratory virus infections in humans, including that of SARS-CoV2. Diagnostic Molecular Biology, Second Edition, is an ideal reference for researchers, lab technicians, and students in medical laboratory science, molecular biology, microbiology, virology, and related fields.

Provides explanations on how techniques are used to diagnosis at the molecular level Explains how to use information technology to communicate and assess results in the lab Enhances our understanding of fundamental molecular biology and places techniques in context Places protocols into context with practical applications Includes extra chapters on respiratory viruses (Corona)

Handbook on New Paradigms in Smart Charging for E-Mobility: Global Trends, Policies and Practices provides a complete package for understanding and developing smart chargers for e-mobility applications. It discusses various concepts required for developing charging infrastructure and usage of different kinds of storage technologies, power electronics converters, controllers, communication requirements, grid infrastructure, sustainable technologies, policy frameworks, and all other related crucial aspects of E-mobility.Each part of the book covers a subdomain of e-mobility, beginning with an introductory chapter reviewing existing literature; the subsequent chapters are arranged to each follow the previous one. Other available books focus on specific technical subdomains of e-mobility, but none provides the wider outlook to meet the requirements of all audiences. This book uniquely brings together topics that are not otherwise easily accessible or available to these audiences.

This book will be beneficial for engineers, scientists, and researchers, providing them with a comprehensive standard benchmark work to explore the evolving aspects of charging infrastructure for e-mobility. Further, it will also help policymakers, practitioners and government entities formulate policies for successful implementations of e-motility for their masses. The techno-socio-economic focus will serve as standard literature for all.

Takes a modular approach, with each module catering to a different sub-domain of e-mobilityIncludes standalone chapters that cover out-of-the-box work related to e-mobilityPresents the latest advances and detailed technical descriptions of smart charging infrastructures

Increasing Management Relevance and Competitiveness contains the papers presented at the Global Conference on Business, Management and Entrepreneurship (the 2nd GC-BME 2017), Surabaya, Indonesia on the 9th of August, 2017.The book covers 7 topics:1. Organizational Behavior, Leadership, and Human Resources Management2. Innovation, Operations and Supply Chain Management3. Marketing Management4. Financial Management and Accounting5. Strategic Management, Entrepreneurship, and Contemporary Issues6. Green Business7. Management and Economics Education.

Excavation, Support and Monitoring is the fourth volume of the five-volume set Rock Mechanics and Engineering and contains twenty-three chapters from key experts in the following fields- Excavation Methods;- Support Technology;- Monitoring Technology;- Integrated Engineering Monitoring and Analysis.The five-volume set “Comprehensive Rock Engineering”, which was published in 1993, has had an important influence on the development of rock mechanics and rock engineering. Significant and extensive advances and achievements in these fields over the last 20 years now justify the publishing of a comparable, new compilation. Rock Mechanics and Engineering represents a highly prestigious, multi-volume work edited by Professor Xia-Ting Feng, with the editorial advice of Professor John A. Hudson. This new compilation offers an extremely wide-ranging and comprehensive overview of the state-of-the-art in rock mechanics and rock engineering and is composed of peer-reviewed, dedicated contributions by all the key experts worldwide.Key features of this set are that it provides a systematic, global summary of new developments in rock mechanics and rock engineering practices as well as looking ahead to future developments in the fields. Contributors are world-renowned experts in the fields of rock mechanics and rock engineering, though younger, talented researchers have also been included. The individual volumes cover an extremely wide array of topics grouped under five overarching themes: Principles (Vol. 1), Laboratory and Field Testing (Vol. 2), Analysis, Modelling and Design (Vol. 3), Excavation, Support and Monitoring (Vol. 4) and Surface and Underground Projects (Vol. 5). This multi-volume work sets a new standard for rock mechanics and engineering compendia and will be the go-to resource for all engineering professionals and academics involved in rock mechanics and engineering for years to come.

Prevention of Accidents at Work collects papers presented at the 9th International Conference on the Prevention of Accidents at Work (WOS 2017) held in Prague, Czech Republic, on October 3-6, 2017, organized by the VSB-Technical University of Ostrava. The conference on current issues within occupational safety is organized under the umbrella of Workingonsafety.net (WOS.net). WOS.net is an international network of decision-makers, researchers and professionals responsible for the prevention of accidents and trauma at work. The network aims to bring accident prevention experts together in order to facilitate the exchange of experience, new findings and best practices between different countries and sectors. WOS.net is supported by the European Agency for Safety and Health at Work (EU-OSHA).The overall theme is safety management complexity in a changing society, with the motto: Do we need a holistic approach? Underlying topics include: Foundations of safety science: theories, principles, methods and tools; Research to practice: achievements, lessons learned and challenges; Risk management and safety culture: case studies, best practices and further needs; Safety regulation: reasonable practicable approach; Education and training: prerequisite for safety; Complexity and safety: multidisciplinarity and inter-stakeholder views. Prevention of Accidents at Work should be valuable to researchers, policy makers, safety professionals, labor inspectors, labor administrators and other experts in the prevention of occupational accidents.

Physical Modelling in Geotechnics collects more than 1500 pages of peer-reviewed papers written by researchers from over 30 countries, and presented at the 9th International Conference on Physical Modelling in Geotechnics 2018 (City, University of London, UK 17-20 July 2018). The ICPMG series has grown such that two volumes of proceedings were required to publish all contributions. The books represent a substantial body of work in four years. Physical Modelling in Geotechnics contains 230 papers, including eight keynote and themed lectures representing the state-of-the-art in physical modelling research in aspects as diverse as fundamental modelling including sensors, imaging, modelling techniques and scaling, onshore and offshore foundations, dams and embankments, retaining walls and deep excavations, ground improvement and environmental engineering, tunnels and geohazards including significant contributions in the area of seismic engineering. ISSMGE TC104 have identified areas for special attention including education in physical modelling and the promotion of physical modelling to industry. With this in mind there is a special themed paper on education, focusing on both undergraduate and postgraduate teaching as well as practicing geotechnical engineers. Physical modelling has entered a new era with the advent of exciting work on real time interfaces between physical and numerical modelling and the growth of facilities and expertise that enable development of so called ‘megafuges’ of 1000gtonne capacity or more; capable of modelling the largest and most complex of geotechnical challenges. Physical Modelling in Geotechnics will be of interest to professionals, engineers and academics interested or involved in geotechnics, geotechnical engineering and related areas. The 9th International Conference on Physical Modelling in Geotechnics was organised by the Multi Scale Geotechnical Engineering Research Centre at City, University of London under the auspices of Technical Committee 104 of the International Society for Soil Mechanics and Geotechnical Engineering (ISSMGE). City, University of London, are pleased to host the prestigious international conference for the first time having initiated and hosted the first regional conference, Eurofuge, ten years ago in 2008. Quadrennial regional conferences in both Europe and Asia are now well established events giving doctoral researchers, in particular, the opportunity to attend an international conference in this rapidly evolving specialist area.This is volume 2 of a 2-volume set.

This book is Volume 2 of the EUROCK 2018 proceedings. Geomechanics and Geodynamics of Rock Masses contains contributions presented at EUROCK 2018, the 2018 International Symposium of the International Society for Rock Mechanics (ISRM 2018, Saint Petersburg, Russia, 22-26 May 2018). Dedicated to recent advances and achievements in the fields of geomechanics and geotechnology, the main topics of the book include:- Physical and mechanical properties of fractured rock (laboratory testing and rock properties, field measurements and site investigations)- Geophysics in rock mechanics- Rock mass strength and failure- Nonlinear problems in rock mechanics- Effect of joint water on the behavior of rock foundation- Numerical modeling and back analysis- Mineral resources development: methods and rock mechanics problems- Rock mechanics and underground construction in mining, hydropower industry and civil engineering- Rock mechanics in petroleum engineering- Geodynamics and monitoring of rock mass behavior- Risks and hazards- Geomechanics of technogenic depositsGeomechanics and Geodynamics of Rock Masses will be of interest to researchers and professionals involved in the various branches of rock mechanics and rock engineering. EUROCK 2018, organized by the Saint Petersburg Mining University, is a continuation of the successful series of ISRM symposia in Europe, which began in 1992 in Chester, UK.

This volume contains the papers presented at the Fourth International Conference of Thin-Walled Structures (ICTWS4), and contains 110 papers which, collectively, provide a comprehensive state-of-the-art review of the progress made in research, development and manufacture in recent years in thin-walled structures.The presentations at the conference had representation form 35 different countries and their topical areas of interest included aeroelastic response, structural-acoustic coupling, aerospace structures, analysis, design, manufacture, cold-formed structures, cyclic loading, dynamic loading, crushing, energy absorption, fatigue, fracture, damage tolerance, plates, stiffened panels, plated structures, polymer matrix composite members, sandwich structures, shell structures, thin-walled beams, columns and vibrational response. The range of applications of thin-walled structures has become increasingly diverse with a considerable deployment of thin-walled structural elements and systems being found in a wide range of areas within Aeronautical, Automotive, Civil, Mechanical, Chemical and Offshore Engineering fields. This volume is an extremely useful reference volume for researchers and designers working within a wide range of engineering disciplines towards the design, development and manufacture of efficient thin-walled structural systems.

This collection features five peer-reviewed reviews on optimising photosynthesis in crops.The first chapter reviews current understanding of the biochemistry, regulation and limitation of the C3 photosynthesis cycle in crops. It provides detailed discussions on CO2 assimilation in C3 photosynthesis, as well as the carboxylation, reduction and regeneration phases of the C3 cycle.The second chapter considers the recent emergence of using phenotyping techniques to analyse crop functionality and photosynthesis. It reviews the relationship between photosynthesis, crop growth and stress response and explores phenotyping photosynthesis in varying environments.The third chapter discusses the process of modifying mesophyll conductance to optimise photosynthesis in crops. The chapter considers recent research efforts to manipulate the structure and composition of cells walls, membranes and liquid phases to achieve this.The fourth chapter explores improving photosynthesis in rice and details the need to optimise photosynthetic efficiency as a means of boosting yield ceilings in rice production.The final chapter reviews some of the key factors determining photosynthetic performance and explores the options for improving the photosynthetic capacity and efficiency of wheat by selecting for a range of important traits.

Since January 2004, Mossbauer spectrometers [1] have been making measurements on Mars as a component of the Athena instrument suite because the technique can "yield information about early Martian environmental conditions" and can help in "identifying minerals formed in hot, watery environments that could preserve fossil evidence of Martian life" (from an early Athena web site; cf. [2]). The spectrometers are mounted on the instrument deployment armsoftwo Mars Exploration Rovers, MER-A (Spirit) and MER-B (Opportunity), where they have access to a wide range of rocks and soils. Initial measurements at the Spirit site showed that surface samples contained primarily basaltic minerals with weathering by physical processes [3], while mineralogy inferred from data acquired at the Opportunity site provided evidence for past aqueous processes [4]. More recently, Mossbauer spectroscopy has identified goethite at Columbia Hills [5] and contributed to an understanding of the nature of Martian atmospheric dust and its implications for the history of water on Mars [6]. It is important that MER-team results be verified and expanded upon. Since August 2004, Mars Mossbauer and related data, with supporting documentation, have been made available to the science community via the Planetary Data System (PDS) at the MER Analyst's Notebook download site (http://www. anserverl. eprsl. wustl. edu/) and at the PDS Geosciences Node (http://www. pds-geosciences. wustl. edu/).

Since January 2004, Mossbauer spectrometers [1] have been making measurements on Mars as a component of the Athena instrument suite because the technique can "yield information about early Martian environmental conditions" and can help in "identifying minerals formed in hot, watery environments that could preserve fossil evidence of Martian life" (from an early Athena web site; cf. [2]). The spectrometers are mounted on the instrument deployment armsoftwo Mars Exploration Rovers, MER-A (Spirit) and MER-B (Opportunity), where they have access to a wide range of rocks and soils. Initial measurements at the Spirit site showed that surface samples contained primarily basaltic minerals with weathering by physical processes [3], while mineralogy inferred from data acquired at the Opportunity site provided evidence for past aqueous processes [4]. More recently, Mossbauer spectroscopy has identified goethite at Columbia Hills [5] and contributed to an understanding of the nature of Martian atmospheric dust and its implications for the history of water on Mars [6]. It is important that MER-team results be verified and expanded upon. Since August 2004, Mars Mossbauer and related data, with supporting documentation, have been made available to the science community via the Planetary Data System (PDS) at the MER Analyst''s Notebook download site (http://www. anserverl. eprsl. wustl. edu/) and at the PDS Geosciences Node (http://www. pds-geosciences. wustl. edu/).

Since January 2004, Mossbauer spectrometers [1] have been making measurements on Mars as a component of the Athena instrument suite because the technique can "yield information about early Martian environmental conditions" and can help in "identifying minerals formed in hot, watery environments that could preserve fossil evidence of Martian life" (from an early Athena web site; cf. [2]). The spectrometers are mounted on the instrument deployment armsoftwo Mars Exploration Rovers, MER-A (Spirit) and MER-B (Opportunity), where they have access to a wide range of rocks and soils. Initial measurements at the Spirit site showed that surface samples contained primarily basaltic minerals with weathering by physical processes [3], while mineralogy inferred from data acquired at the Opportunity site provided evidence for past aqueous processes [4]. More recently, Mossbauer spectroscopy has identified goethite at Columbia Hills [5] and contributed to an understanding of the nature of Martian atmospheric dust and its implications for the history of water on Mars [6]. It is important that MER-team results be verified and expanded upon. Since August 2004, Mars Mossbauer and related data, with supporting documentation, have been made available to the science community via the Planetary Data System (PDS) at the MER Analyst's Notebook download site (http://www. anserverl. eprsl. wustl. edu/) and at the PDS Geosciences Node (http://www. pds-geosciences. wustl. edu/).

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

This is the sixth set of Handbook of Porphyrin Science.This 5-volume set provides a comprehensive review of the most up-to-date research on porphyrin, heme and chlorophyll biochemistry, as well as applications to biomedicine and bio-inspired energy. In-depth coverage of topics along with perspectives on outstanding questions and future research directions by the authors make these volumes an essential resource for both beginning and advanced investigators in the field. It is also suitable for non-experts in porphyrin, who wish to have an overview of the fundamental discoveries and breakthroughs in the porphyrin arena related to medicine and bio-inspired energy.Bringing together the biochemistry of porphyrin-binding proteins and their clinical relevance and applications to medicine and renewable energy, this set provides readers with an integrated coverage of porphyrin biochemistry. At the same time, it challenges readers with new questions and perspectives of research regarding the role of porphyrin biochemistry in the future of medicine and renewable energy.

This is the sixth set of Handbook of Porphyrin Science.This 5-volume set provides a comprehensive review of the most up-to-date research on porphyrin, heme and chlorophyll biochemistry, as well as applications to biomedicine and bio-inspired energy. In-depth coverage of topics along with perspectives on outstanding questions and future research directions by the authors make these volumes an essential resource for both beginning and advanced investigators in the field. It is also suitable for non-experts in porphyrin, who wish to have an overview of the fundamental discoveries and breakthroughs in the porphyrin arena related to medicine and bio-inspired energy.Bringing together the biochemistry of porphyrin-binding proteins and their clinical relevance and applications to medicine and renewable energy, this set provides readers with an integrated coverage of porphyrin biochemistry. At the same time, it challenges readers with new questions and perspectives of research regarding the role of porphyrin biochemistry in the future of medicine and renewable energy.

This is the sixth set of Handbook of Porphyrin Science.This 5-volume set provides a comprehensive review of the most up-to-date research on porphyrin, heme and chlorophyll biochemistry, as well as applications to biomedicine and bio-inspired energy. In-depth coverage of topics along with perspectives on outstanding questions and future research directions by the authors make these volumes an essential resource for both beginning and advanced investigators in the field. It is also suitable for non-experts in porphyrin, who wish to have an overview of the fundamental discoveries and breakthroughs in the porphyrin arena related to medicine and bio-inspired energy.Bringing together the biochemistry of porphyrin-binding proteins and their clinical relevance and applications to medicine and renewable energy, this set provides readers with an integrated coverage of porphyrin biochemistry. At the same time, it challenges readers with new questions and perspectives of research regarding the role of porphyrin biochemistry in the future of medicine and renewable energy.

This is the sixth set of Handbook of Porphyrin Science.This 5-volume set provides a comprehensive review of the most up-to-date research on porphyrin, heme and chlorophyll biochemistry, as well as applications to biomedicine and bio-inspired energy. In-depth coverage of topics along with perspectives on outstanding questions and future research directions by the authors make these volumes an essential resource for both beginning and advanced investigators in the field. It is also suitable for non-experts in porphyrin, who wish to have an overview of the fundamental discoveries and breakthroughs in the porphyrin arena related to medicine and bio-inspired energy.Bringing together the biochemistry of porphyrin-binding proteins and their clinical relevance and applications to medicine and renewable energy, this set provides readers with an integrated coverage of porphyrin biochemistry. At the same time, it challenges readers with new questions and perspectives of research regarding the role of porphyrin biochemistry in the future of medicine and renewable energy.