Awanish Kumar – författare

Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules.

Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines.

Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics.

Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs Provides thorough information on candida drug resistance and its remedial implications Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics

Visceral Leishmaniasis: Therapeutics and Vaccines describes current therapeutics, natural anti-leishmanial molecules, anti-leishmanial screening, and explores vaccine candidates and amastigote-based vaccination strategies for Leishmania. The book provides a precise view on VL, Leishmania parasite culture, host immunity and immunomodulation, natural compounds effective against VL, animal models for VL, and methodologies available for anti-leishmanial drug screening procedures against VL, as well as vaccine and vaccination-related information on Leishmaniasis.� Readers will find concrete information on past and current hurdles facing vaccine development for Leishmania, along with scientific opportunities and the potential impact of vaccines, including problems encountered.

The book is designed to increase the understanding of vaccines, particularly in VL, for students and researchers. Although vaccines are now available for many diseases, there are still challenges ahead for a vaccine for VL. The ideal vaccine must be safe and able to induce an immune response that is strong and effective. In a nutshell, a combination of chemotherapy (drugs) and immunoprophylaxis (vaccine) would be ideal to win the battle against VL.

Provides the first dedicated book on Visceral Leishmaniasis (VL) and anti-leishmanial screening Covers major aspects of the fatal disease Visceral Leishmaniasis Provides plenty of illustrations and figures Includes methods of anti-leishmanial drug screening Expands the perspective of readers on the complex problem of drug screening

Phytoconstituents and Antifungals covers a wide range of specific information on various phytoconstituents, their antifungal mode and the diagnosis and management of fungal infections. The book offers encouragement and empowers readers to re-embrace their knowledge of phytoconstituents and their various antifungal activities against most opportunistic pathogenic fungi as fungal diseases cause an estimated 1.5+ million deaths annually and over one billion people suffer from severe fungal disease. In this complex scenario, it is now clear that global warming and accompanying climate changes have resulted in increased incidence of many fungal infections.

On the basis of all these factors, concerns on the occurrence of a pandemic fungal origin in the near future have been raised. In this context, to stop forgetting and underestimating fungal diseases is mandatory.

Provides readers with up-to-date information on different phytoconstituents over fungal strain Collectively addresses important and updated material on fungal diseases Conveys the knowledge needed to understand and improve success in managing and combating fungal diseases worldwide

Antimicrobial Resistance in Wastewater and Human Health provides updated knowledge on the human health risks associated with antimicrobial resistance of wastewater. The book's chapters address commonly found bacteria and drug resistant genes in wastewater, treatment plant problems and challenges, human health hazards, and gaps in current literature. Written for researchers, scientists, graduate and PhD students in the areas of Public Health, Biotechnology, Chemical Engineering, and Environmental Science, this will be an ideal resource. Examines AMR in wastewater and related risks to human health Provides the reader with expert analysis across a variety of scientific disciplines Presents a comprehensive analysis of AMR in wastewater, risks to human health and the way forward

Diabetes: Epidemiology, Pathophysiology and Clinical Management aims to be the one-stop diabetes book for researchers, scientists and clinicians. It details the epidemiology, causes, molecular mechanisms, molecular markers, available drugs, experimental drugs, treatment modalities, and dietary and lifestyle approaches related to diabetes. It focuses on various molecular aspects of diabetes, and its related co-morbidities. Apart from the drug-based treatment approach based on international guidelines, this book also describes various surgical treatments available for cases of uncontrolled symptomatic diabetes. It also lays emphasis on the future possibilities of different approaches for diabetes management. Key Features Includes treatment guidelines and approaches to diabetes provided by major global diabetes associationsProvides a thorough and comprehensive assimilation of detailed information and updates in the field of diabetes, helpful for researchers, scientists and cliniciansContains a chapter on anti-diabetic drugs, that covers both the commercially approved drugs as well as those that are in various phases of experimental, pre-clinical, and clinical trials

Diabetes: Epidemiology, Pathophysiology and Clinical Management aims to be the one-stop diabetes book for researchers, scientists and clinicians. It details the epidemiology, causes, molecular mechanisms, molecular markers, available drugs, experimental drugs, treatment modalities, and dietary and lifestyle approaches related to diabetes. It focuses on various molecular aspects of diabetes, and its related co-morbidities. Apart from the drug-based treatment approach based on international guidelines, this book also describes various surgical treatments available for cases of uncontrolled symptomatic diabetes. It also lays emphasis on the future possibilities of different approaches for diabetes management. Key Features Includes treatment guidelines and approaches to diabetes provided by major global diabetes associationsProvides a thorough and comprehensive assimilation of detailed information and updates in the field of diabetes, helpful for researchers, scientists and cliniciansContains a chapter on anti-diabetic drugs, that covers both the commercially approved drugs as well as those that are in various phases of experimental, pre-clinical, and clinical trials

Pathogenic Viruses and Armamentarium Design covers the latest developments in viral target elucidation and viral control using wet and dry lab strategies. The control and combat strategies and their implementation compiled in this book are invaluable in aiding the understanding of viral disease progression and for designing new strategies against existing and evolving viruses.This important resource is a comprehensive compilation of antiviral approaches designed and devised using computational and other laboratory techniques. This book is a useful reference for scientists, researchers, industry professionals, advanced students, and postgraduates in virology, biotechnology, infection biology, biochemistry, and pharmaceutical sciences who engaged in the study of pathogenic virus and the development of prophylactics and therapeutics against viral infection.

Provides an overview of human pathogenic viruses, viral entry and disease progression, and strategic approaches tocombating existing and evolving virusesExplores available techniques for clinical diagnostics, virology, and viral immune diagnosticsComprehensively discusses antiviral drugs, their targets, mechanism of action, design, and development challenges

Secondary Metabolites and Biotherapeutics presents the latest biotechnological advancements in the production of target secondary metabolites for medicinal use, including topics such as transcriptomics, nanotechnology, gene editing tools like CRISPR/CAS, secondary metabolites source and production.? Secondary metabolites derived from plants as a response to stress have always played a vital role in the pharmaceutical industry to produce medicines. However, their limited production in plants have always raised concerns for large-scale production. With the advancement of modern biotechnology, researchers around the globe are now able to engineer plants with specific chemical compositions.This book is a valuable resource to researchers in biotechnology, medical sciences, pharmaceutical biotechnology, pharmacology and plant biology.Provides updates in the field of secondary metabolite used in therapy?Covers the latest biotechnological advancements in the production of target secondary metabolites for the purpose of medicinal use?Elucidates the medicinal value of the plants used traditionally by different ethnic groups for treating various disorders?Presents the medicinal value of endophytes

Developments of antifungal agents have declined as compared to other antibiotics that have displayed a potent development with time. There is an urgent need for both prophylactic and therapeutic treatments worldwide to control the severity of infections caused by Candida. Anticandidal Therapeutics: Discovery and Development provides the readers with a compiled knowledge of the fungal human infection Candida and the development of anticandidal drugs. Anticandidal Therapeutics helps researchers form the basis for the discovery and development of novel anticandidal therapies. In 14 chapters this book provides collective information on anticandidal agents and their discovery and development with respect to major drug transporter families, different stages of anticandidal agent development, recent trends and progress in antifungal translational research, clinical studies status of anticandidal therapeutic agents, and drug repurposing for development of novel anticandidal agents.

Highlights the mechanistic actions of some therapeutic agents against Candida Focuses on anticandidal agents rather than general antifungal agents Discusses the stage of development of new antifungal drugs, the repositioning of drugs, and how this could help in treatment

Salmonella Biofilms, Infection, and Therapeutic Management provides an overview of salmonella biofilms, their detection and identification, associated salmonellosis infection, prevention and treatment.The book discusses salmonella, the formation of biofilm, and biofilm associated bacterial infection. It aims to provide insight on how salmonellosis and biofilm relate to one another as well as how they relate to other diseases in the host. It also discusses the therapeutic strategy for reducing salmonella infection and current treatment options. Salmonella Biofilms, Infection, and Therapeutic Management is a useful reference for those engaged in the study of the study of salmonella biofilm, its formation, disease manifestation, and management.

Provides the most recent knowledge on salmonellosis and its relationship to biofilmDescribes different types of salmonella bacteria and biofilm as well as the regulatory and virulence mechanisms of salmonellaExamines the mechanisms of Salmonella biofilm formation and the relationship between this and other aspects of Salmonella physiology

Antibiotic Resistance and Nanotherapy is a comprehensive guide that explores an interdisciplinary approach to address the pressing issue of antibiotic resistance and explores the possibility of nanotherapy as a cutting-edge strategy to treat illnesses that are resistant to antibiotics, employing nanoparticles to target and kill bacteria selectively without damaging healthy cells. It details the underlying mechanisms of drug resistance in intracellular and extracellular pathogens and explores the latest advancements in nanotechnology, including the development of innovative nanomaterials and delivery systems that can be utilized to combat antibiotic-resistant infections. This book also discusses the ethical and practical challenges associated with implementing nanotherapy for bacterial resistance. Featuring contributions from experts in the field, this book is an essential resource for researchers, medical professionals, and policymakers seeking to understand and tackle the immediate threat posed by antibiotic resistance.Examines the current state of antimicrobial resistance, its impact on global health, and the rise of drug-resistant "superbugs"Demonstrates how nanotherapeutics using diverse nanoparticles can be used to address antibiotic resistanceProvides in-depth discussions of the mechanisms underlying antibiotic resistance, the prospect of antibiotic-resistant infection treatments based on nanotechnology, and the most recent developments in nanotechnology-based diagnostics

Diabetes and Alzheimer's Disease: Mechanisms and Management delves into the complex relationship between diabetes and Alzheimer’s disease. The book examines how these conditions intersect and influence each other, providing insights into their pathophysiological and epidemiological aspects. Readers will gain a thorough understanding of metabolic interactions, molecular signaling, and various factors that regulate the confluence of these diseases. Written by experts, this comprehensive guide is essential for researchers, academicians, scientists, and graduate students in biomedical and pharmaceutical sciences. In addition to exploring the mechanisms, the book discusses theranostics and strategies to manage both conditions.It includes sections on drug repositioning, dietary modifications, and the impact of metabolic dysfunction on neurological disorders.Introduces the relationship between diabetes and Alzheimer's diseaseProvides a detailed analysis of pathology and theronostics of diabetes and Alzheimer's diseasePresents information on molecular and biochemical factors involved in diabetes and Alzheimer's disease

Next-Generation Onco-Therapeutics explores the latest advancements in cancer treatment, focusing on personalized medicine and innovative therapeutic strategies. The book serves as a comprehensive resource for understanding how emerging technologies can reshape oncological care, providing insights into effective and compassionate patient management. Content explores cutting-edge developments in cancer therapies, featuring clinical examples and case studies that illustrate the practical application of new treatment modalities. It emphasizes the importance of integrative approaches that address the diverse needs of cancer patients, ensuring that healthcare professionals are equipped with the most current information in this rapidly evolving field. This book also addresses the urgent need for updated resources in oncological therapeutics, bridging the gap between traditional practices and modern innovations. By synthesizing diverse perspectives and evidence-based insights, it empowers healthcare providers, researchers, and policymakers to enhance treatment outcomes and improve patient well-being in the era of personalized medicine.Provides comprehensive coverage on the latest advancements in cancer treatment, ensuring that healthcare professionals stay informed about innovative therapies and techniquesIncludes clinical examples and case studies that illustrate how new treatment modalities are effectively applied in real-world settings, thus enhancing understanding and implementationEmphasizes integrative and personalized medicine approaches that cater to the diverse needs and preferences of cancer patients

Healing Botanicals: From Tradition to Therapeutics explores the connection between traditional herbal wisdom and modern medical science, examining herbaceuticals-plant-derived compounds with therapeutic potential-through the lens of clinical evidence, pharmacology, and global healthcare practices. Organized into five parts, the book begins by tracing the evolution of herbal medicine and delving into the phytochemical and pharmacological foundations of healing botanicals. Subsequent sections focus on botanicals for stress, immunity, digestion, chronic pain, mental health, and cardiovascular support, highlighting their applications in disease management.Special emphasis is placed on the integration of adaptogens, immune-boosting herbs, and neuroprotective botanicals in contemporary therapeutic strategies. In addition to therapeutic uses, the book addresses critical concerns such as safety, clinical validation, regulatory frameworks, and quality control. It concludes by forecasting the future of herbal medicine, exploring innovations, global trends, and the potential of plant-based therapies in preventive and personalized healthcare.Presents scientific validation of herbal medicineIntegrates traditional knowledge with modern scienceIncludes applications in health and disease management

Emergent Nanotherapeutics in Diabetic Complications explores how cutting-edge nanotechnology is transforming the treatment of diabetes-related disorders beyond glycemic control. This comprehensive volume examines targeted, multifunctional nanoplatforms designed to address the wide range of comorbidities linked to diabetes, including vascular complications, metabolic dysfunctions, and impaired wound healing. Structured in five parts, the book spans from current nanoformulation strategies to emerging innovations such as CRISPR-Cas9 delivery, AI-guided nanoparticles, and 3D/4D printed nanostructures.Bridging the gap between preclinical research and clinical application, it offers valuable guidance on stimuli-responsive systems, biocompatible materials, and regulatory pathways. This is essential resource for medical professionals, biomedical engineers, and pharmaceutical scientists seeking scalable, next-generation solutions for managing diabetic complications through nanomedicine.Focuses on nanotherapeutics for diabetes-related complications, not just glucose controlCovers nano-drug delivery systems for improved wound healing and comorbidity managementHighlights next-generation technologies like CRISPR-Cas9, AI-driven nanoparticles, and 3D/4D nanostructuresIncludes guidance on translational research, clinical developments, and regulatory considerations

Combinatorial Enzyme Therapy Against ESKAPE Pathogenic Biofilms offers the latest insights into ESKAPE pathogen biofilms, including their formation, structure, and resistance mechanisms. In addition, the book highlights innovative therapeutic strategies to combat them, with a specific focus on combinatorial enzyme therapies. It begins with an overview of the significant burden these pathogens impose across healthcare and the food industry, laying the groundwork for understanding the intricate relationship between antibiotic resistance and biofilm dynamics. The book advocates for novel approaches through combinatorial enzymatic therapy, detailing the mechanisms and synergies of various enzymes in effectively dismantling biofilms.With insights into cutting-edge delivery systems, including nanotechnology and the integration of CRISPR-Cas systems and artificial intelligence, the book charts a course for the future of advanced therapeutic strategies. It concludes by addressing regulatory considerations, positioning combinatorial enzyme therapy as a promising frontier in the fight against persistent infections caused by ESKAPE pathogens.Provides a comprehensive understanding of the mechanisms behind biofilm formation and its role in antimicrobial resistance in ESKAPE pathogensExplores actionable strategies through combinatorial enzyme therapies, offering novel tools to dismantle biofilm matrices and enhance treatment outcomesBridges the gap between research and clinical application by delivering practical insights that enable the adoption of enzyme-based solutions in real-world scenarios

Peptides in Antifungal Therapy: Cutting-Edge Innovations and Clinical Applications takes an interdisciplinary and comprehensive approach to antifungal peptides and the effective ways they can be utilized to combat fungal infections and improve antifungal therapies. The book begins with an introduction to antifungal peptides. It also discusses the natural and synthetic sources of antifungal peptides, details the molecular mechanisms by which these peptides fight fungal infections, and explores the clinical applications and deliver the therapeutic potential of antifungal peptides. This book will be a very useful resource for those engaged in the study of fungal infections and peptide-based therapeutics.Discusses the innovative use of antifungal peptides in clinical applications and the development of therapeuticsOffers potential sources of antifungal peptides and analyzes mechanisms in combating infectionsExplores biotechnological approaches, such as the application of nanotechnology, to improve the targeting and efficacy of antifungal peptidesConsiders the challenges and future direction in antifungal peptide research

​Leishmania-related illnesses remain among the world’s deadliest neglected tropical diseases, affecting approximately 12 million people in 88 countries. The mortality rate is substantial, contributing to nearly two million disability-adjusted life years. As more is understood about this parasite and its effects, work toward prevention, control, and treatment continues apace. Leishmania and Leishmaniasis will address the parasite and its attendant disease, which manifests in three syndromes: Visceral (VL), Cutaneous (CL) and Mucocutaneous Leishmaniasis (ML). The morphology and life cycles of the various species will be among the topics addressed in Part One. Part Two will focus on immunology, including host-immune response to Leishmania infection, cross-immunity between the different species and adoptive transfer of immunity. Parts Three and Four will address how Leishmania invade and survive, the clinical features of the disease, and its diagnosis.  Drugs, vaccines and treatment will be thoroughly explored, including experimental models of therapeutics. Leishmania and Leishmaniasis will provide a thorough examination of a parasite, the illnesses it causes and the misery it continues to visit upon large segments of the population.​

Up to 80% of chronic and recurrent human bacterial infections are caused by bacterial biofilms, which are extremely hard to cure. Salmonella is an especially interesting pathogen because of its ability to cause diseases through a variety of mechanisms and form complex communities in biofilms.Due to the difficulty of treatment, investigation of alternatives to conventional antibiotics is an important direction of research in combating biofilm formation including natural products, nanoparticles, matrix degrading enzymes or combinatorial enzymes, quorum quenching, and novel combinations with other therapies such as PDT and surgical intervention.This book covers the process of Salmonella infection and mechanisms of biofilm formation, current and emerging therapeutic management strategies against Salmonella biofilms as well as the limitations of existing treatment options. It also covers the complex relationship between biofilm infection and other co-morbidities.The book will be of interest to advanced students and researchers interested in antimicrobial resistance, bacteriology, antibiotic drug development, and related research.

For researchers and food industry professionals seeking a comprehensive, fully up to date single source on nanotechnology in food packaging, this text provides all the needed information.

Detailed discussions on the role of bacterial biofilms in dental disease, tonsilitis, tuberculosis, typhoid, endocarditis, ulcer, bone infections, urinary tract infections, chronic wound infections and cancer have been presented individually in chapters 6-15.

This book will explore the knowledge of current diagnostic automation techniques applied in the field of clinical microbiology, tropical diseases, POCT, etc. This book covers the recent updates and advances in diagnostic microbiology and provides new techniques related to Genomic, Proteomic, and metabolomics in microbiology.