Awanish Kumar - Böcker

Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules.

Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines.

Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics.

Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs Provides thorough information on candida drug resistance and its remedial implications Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics

Visceral Leishmaniasis: Therapeutics and Vaccines describes current therapeutics, natural anti-leishmanial molecules, anti-leishmanial screening, and explores vaccine candidates and amastigote-based vaccination strategies for Leishmania. The book provides a precise view on VL, Leishmania parasite culture, host immunity and immunomodulation, natural compounds effective against VL, animal models for VL, and methodologies available for anti-leishmanial drug screening procedures against VL, as well as vaccine and vaccination-related information on Leishmaniasis.� Readers will find concrete information on past and current hurdles facing vaccine development for Leishmania, along with scientific opportunities and the potential impact of vaccines, including problems encountered.

The book is designed to increase the understanding of vaccines, particularly in VL, for students and researchers. Although vaccines are now available for many diseases, there are still challenges ahead for a vaccine for VL. The ideal vaccine must be safe and able to induce an immune response that is strong and effective. In a nutshell, a combination of chemotherapy (drugs) and immunoprophylaxis (vaccine) would be ideal to win the battle against VL.

Provides the first dedicated book on Visceral Leishmaniasis (VL) and anti-leishmanial screening Covers major aspects of the fatal disease Visceral Leishmaniasis Provides plenty of illustrations and figures Includes methods of anti-leishmanial drug screening Expands the perspective of readers on the complex problem of drug screening

Phytoconstituents and Antifungals covers a wide range of specific information on various phytoconstituents, their antifungal mode and the diagnosis and management of fungal infections. The book offers encouragement and empowers readers to re-embrace their knowledge of phytoconstituents and their various antifungal activities against most opportunistic pathogenic fungi as fungal diseases cause an estimated 1.5+ million deaths annually and over one billion people suffer from severe fungal disease. In this complex scenario, it is now clear that global warming and accompanying climate changes have resulted in increased incidence of many fungal infections.

On the basis of all these factors, concerns on the occurrence of a pandemic fungal origin in the near future have been raised. In this context, to stop forgetting and underestimating fungal diseases is mandatory.

Provides readers with up-to-date information on different phytoconstituents over fungal strain Collectively addresses important and updated material on fungal diseases Conveys the knowledge needed to understand and improve success in managing and combating fungal diseases worldwide

Antimicrobial Resistance in Wastewater and Human Health provides updated knowledge on the human health risks associated with antimicrobial resistance of wastewater. The book's chapters address commonly found bacteria and drug resistant genes in wastewater, treatment plant problems and challenges, human health hazards, and gaps in current literature. Written for researchers, scientists, graduate and PhD students in the areas of Public Health, Biotechnology, Chemical Engineering, and Environmental Science, this will be an ideal resource. Examines AMR in wastewater and related risks to human health Provides the reader with expert analysis across a variety of scientific disciplines Presents a comprehensive analysis of AMR in wastewater, risks to human health and the way forward

Diabetes: Epidemiology, Pathophysiology and Clinical Management aims to be the one-stop diabetes book for researchers, scientists and clinicians. It details the epidemiology, causes, molecular mechanisms, molecular markers, available drugs, experimental drugs, treatment modalities, and dietary and lifestyle approaches related to diabetes. It focuses on various molecular aspects of diabetes, and its related co-morbidities. Apart from the drug-based treatment approach based on international guidelines, this book also describes various surgical treatments available for cases of uncontrolled symptomatic diabetes. It also lays emphasis on the future possibilities of different approaches for diabetes management. Key Features Includes treatment guidelines and approaches to diabetes provided by major global diabetes associationsProvides a thorough and comprehensive assimilation of detailed information and updates in the field of diabetes, helpful for researchers, scientists and cliniciansContains a chapter on anti-diabetic drugs, that covers both the commercially approved drugs as well as those that are in various phases of experimental, pre-clinical, and clinical trials

Diabetes: Epidemiology, Pathophysiology and Clinical Management aims to be the one-stop diabetes book for researchers, scientists and clinicians. It details the epidemiology, causes, molecular mechanisms, molecular markers, available drugs, experimental drugs, treatment modalities, and dietary and lifestyle approaches related to diabetes. It focuses on various molecular aspects of diabetes, and its related co-morbidities. Apart from the drug-based treatment approach based on international guidelines, this book also describes various surgical treatments available for cases of uncontrolled symptomatic diabetes. It also lays emphasis on the future possibilities of different approaches for diabetes management. Key Features Includes treatment guidelines and approaches to diabetes provided by major global diabetes associationsProvides a thorough and comprehensive assimilation of detailed information and updates in the field of diabetes, helpful for researchers, scientists and cliniciansContains a chapter on anti-diabetic drugs, that covers both the commercially approved drugs as well as those that are in various phases of experimental, pre-clinical, and clinical trials

Pathogenic Viruses and Armamentarium Design covers the latest developments in viral target elucidation and viral control using wet and dry lab strategies. The control and combat strategies and their implementation compiled in this book are invaluable in aiding the understanding of viral disease progression and for designing new strategies against existing and evolving viruses.This important resource is a comprehensive compilation of antiviral approaches designed and devised using computational and other laboratory techniques. This book is a useful reference for scientists, researchers, industry professionals, advanced students, and postgraduates in virology, biotechnology, infection biology, biochemistry, and pharmaceutical sciences who engaged in the study of pathogenic virus and the development of prophylactics and therapeutics against viral infection.

Provides an overview of human pathogenic viruses, viral entry and disease progression, and strategic approaches tocombating existing and evolving virusesExplores available techniques for clinical diagnostics, virology, and viral immune diagnosticsComprehensively discusses antiviral drugs, their targets, mechanism of action, design, and development challenges

Secondary Metabolites and Biotherapeutics presents the latest biotechnological advancements in the production of target secondary metabolites for medicinal use, including topics such as transcriptomics, nanotechnology, gene editing tools like CRISPR/CAS, secondary metabolites source and production.? Secondary metabolites derived from plants as a response to stress have always played a vital role in the pharmaceutical industry to produce medicines. However, their limited production in plants have always raised concerns for large-scale production. With the advancement of modern biotechnology, researchers around the globe are now able to engineer plants with specific chemical compositions.This book is a valuable resource to researchers in biotechnology, medical sciences, pharmaceutical biotechnology, pharmacology and plant biology.Provides updates in the field of secondary metabolite used in therapy?Covers the latest biotechnological advancements in the production of target secondary metabolites for the purpose of medicinal use?Elucidates the medicinal value of the plants used traditionally by different ethnic groups for treating various disorders?Presents the medicinal value of endophytes

Developments of antifungal agents have declined as compared to other antibiotics that have displayed a potent development with time. There is an urgent need for both prophylactic and therapeutic treatments worldwide to control the severity of infections caused by Candida. Anticandidal Therapeutics: Discovery and Development provides the readers with a compiled knowledge of the fungal human infection Candida and the development of anticandidal drugs. Anticandidal Therapeutics helps researchers form the basis for the discovery and development of novel anticandidal therapies. In 14 chapters this book provides collective information on anticandidal agents and their discovery and development with respect to major drug transporter families, different stages of anticandidal agent development, recent trends and progress in antifungal translational research, clinical studies status of anticandidal therapeutic agents, and drug repurposing for development of novel anticandidal agents.

Highlights the mechanistic actions of some therapeutic agents against Candida Focuses on anticandidal agents rather than general antifungal agents Discusses the stage of development of new antifungal drugs, the repositioning of drugs, and how this could help in treatment

Salmonella Biofilms, Infection, and Therapeutic Management provides an overview of salmonella biofilms, their detection and identification, associated salmonellosis infection, prevention and treatment.The book discusses salmonella, the formation of biofilm, and biofilm associated bacterial infection. It aims to provide insight on how salmonellosis and biofilm relate to one another as well as how they relate to other diseases in the host. It also discusses the therapeutic strategy for reducing salmonella infection and current treatment options. Salmonella Biofilms, Infection, and Therapeutic Management is a useful reference for those engaged in the study of the study of salmonella biofilm, its formation, disease manifestation, and management.

Provides the most recent knowledge on salmonellosis and its relationship to biofilmDescribes different types of salmonella bacteria and biofilm as well as the regulatory and virulence mechanisms of salmonellaExamines the mechanisms of Salmonella biofilm formation and the relationship between this and other aspects of Salmonella physiology

Antibiotic Resistance and Nanotherapy is a comprehensive guide that explores an interdisciplinary approach to address the pressing issue of antibiotic resistance and explores the possibility of nanotherapy as a cutting-edge strategy to treat illnesses that are resistant to antibiotics, employing nanoparticles to target and kill bacteria selectively without damaging healthy cells. It details the underlying mechanisms of drug resistance in intracellular and extracellular pathogens and explores the latest advancements in nanotechnology, including the development of innovative nanomaterials and delivery systems that can be utilized to combat antibiotic-resistant infections. This book also discusses the ethical and practical challenges associated with implementing nanotherapy for bacterial resistance. Featuring contributions from experts in the field, this book is an essential resource for researchers, medical professionals, and policymakers seeking to understand and tackle the immediate threat posed by antibiotic resistance.Examines the current state of antimicrobial resistance, its impact on global health, and the rise of drug-resistant "superbugs"Demonstrates how nanotherapeutics using diverse nanoparticles can be used to address antibiotic resistanceProvides in-depth discussions of the mechanisms underlying antibiotic resistance, the prospect of antibiotic-resistant infection treatments based on nanotechnology, and the most recent developments in nanotechnology-based diagnostics

Diabetes and Alzheimer's Disease: Mechanisms and Management delves into the complex relationship between diabetes and Alzheimer’s disease. The book examines how these conditions intersect and influence each other, providing insights into their pathophysiological and epidemiological aspects. Readers will gain a thorough understanding of metabolic interactions, molecular signaling, and various factors that regulate the confluence of these diseases. Written by experts, this comprehensive guide is essential for researchers, academicians, scientists, and graduate students in biomedical and pharmaceutical sciences. In addition to exploring the mechanisms, the book discusses theranostics and strategies to manage both conditions.It includes sections on drug repositioning, dietary modifications, and the impact of metabolic dysfunction on neurological disorders.Introduces the relationship between diabetes and Alzheimer's diseaseProvides a detailed analysis of pathology and theronostics of diabetes and Alzheimer's diseasePresents information on molecular and biochemical factors involved in diabetes and Alzheimer's disease

Next-Generation Onco-Therapeutics explores the latest advancements in cancer treatment, focusing on personalized medicine and innovative therapeutic strategies. The book serves as a comprehensive resource for understanding how emerging technologies can reshape oncological care, providing insights into effective and compassionate patient management. Content explores cutting-edge developments in cancer therapies, featuring clinical examples and case studies that illustrate the practical application of new treatment modalities. It emphasizes the importance of integrative approaches that address the diverse needs of cancer patients, ensuring that healthcare professionals are equipped with the most current information in this rapidly evolving field. This book also addresses the urgent need for updated resources in oncological therapeutics, bridging the gap between traditional practices and modern innovations. By synthesizing diverse perspectives and evidence-based insights, it empowers healthcare providers, researchers, and policymakers to enhance treatment outcomes and improve patient well-being in the era of personalized medicine.Provides comprehensive coverage on the latest advancements in cancer treatment, ensuring that healthcare professionals stay informed about innovative therapies and techniquesIncludes clinical examples and case studies that illustrate how new treatment modalities are effectively applied in real-world settings, thus enhancing understanding and implementationEmphasizes integrative and personalized medicine approaches that cater to the diverse needs and preferences of cancer patients

​Leishmania-related illnesses remain among the world’s deadliest neglected tropical diseases, affecting approximately 12 million people in 88 countries. The mortality rate is substantial, contributing to nearly two million disability-adjusted life years. As more is understood about this parasite and its effects, work toward prevention, control, and treatment continues apace. Leishmania and Leishmaniasis will address the parasite and its attendant disease, which manifests in three syndromes: Visceral (VL), Cutaneous (CL) and Mucocutaneous Leishmaniasis (ML). The morphology and life cycles of the various species will be among the topics addressed in Part One. Part Two will focus on immunology, including host-immune response to Leishmania infection, cross-immunity between the different species and adoptive transfer of immunity. Parts Three and Four will address how Leishmania invade and survive, the clinical features of the disease, and its diagnosis.  Drugs, vaccines and treatment will be thoroughly explored, including experimental models of therapeutics. Leishmania and Leishmaniasis will provide a thorough examination of a parasite, the illnesses it causes and the misery it continues to visit upon large segments of the population.​

Up to 80% of chronic and recurrent human bacterial infections are caused by bacterial biofilms, which are extremely hard to cure. Salmonella is an especially interesting pathogen because of its ability to cause diseases through a variety of mechanisms and form complex communities in biofilms.Due to the difficulty of treatment, investigation of alternatives to conventional antibiotics is an important direction of research in combating biofilm formation including natural products, nanoparticles, matrix degrading enzymes or combinatorial enzymes, quorum quenching, and novel combinations with other therapies such as PDT and surgical intervention.This book covers the process of Salmonella infection and mechanisms of biofilm formation, current and emerging therapeutic management strategies against Salmonella biofilms as well as the limitations of existing treatment options. It also covers the complex relationship between biofilm infection and other co-morbidities.The book will be of interest to advanced students and researchers interested in antimicrobial resistance, bacteriology, antibiotic drug development, and related research.

For researchers and food industry professionals seeking a comprehensive, fully up to date single source on nanotechnology in food packaging, this text provides all the needed information.

This book will explore the knowledge of current diagnostic automation techniques applied in the field of clinical microbiology, tropical diseases, POCT, etc. This book covers the recent updates and advances in diagnostic microbiology and provides new techniques related to Genomic, Proteomic, and metabolomics in microbiology.