Christian Klein – författare
Visar alla böcker från författaren Christian Klein. Handla med fri frakt och snabb leverans.
68 produkter
68 produkter
Inbunden, Engelska, 2021
3 179 kr
Skickas inom 5-8 vardagar
This new edition describes pressure and temperature sensitive paints (PSP and TSP) in global surface pressure and temperature measurements in aerodynamics and fluid mechanics. The book includes the latest progress in paint formulations, instrumentation, and steady and unsteady aerodynamic measurements in various facilities including low-speed, transonic, supersonic and hypersonic wind tunnels. The updated technical aspects of PSP and TSP in the book will be useful for students and researchers in experimental aerodynamics and fluid mechanics.
E-bok
Engelska, 20213 948 kr
Läs direkt efter köp
This new edition describes pressure and temperature sensitive paints (PSP and TSP) in global surface pressure and temperature measurements in aerodynamics and fluid mechanics. The book includes the latest progress in paint formulations, instrumentation, and steady and unsteady aerodynamic measurements in various facilities including low-speed, transonic, supersonic and hypersonic wind tunnels. The updated technical aspects of PSP and TSP in the book will be useful for students and researchers in experimental aerodynamics and fluid mechanics.
Häftad, Engelska, 2022
3 179 kr
Skickas inom 5-8 vardagar
This new edition describes pressure and temperature sensitive paints (PSP and TSP) in global surface pressure and temperature measurements in aerodynamics and fluid mechanics. The book includes the latest progress in paint formulations, instrumentation, and steady and unsteady aerodynamic measurements in various facilities including low-speed, transonic, supersonic and hypersonic wind tunnels. The updated technical aspects of PSP and TSP in the book will be useful for students and researchers in experimental aerodynamics and fluid mechanics.
Del 209 - Applied Mathematical Sciences
Nonlinear Dispersive Equations
Inverse Scattering and PDE Methods
Inbunden, Engelska, 2022
970 kr
Skickas inom 5-8 vardagar
Nonlinear Dispersive Equations are partial differential equations that naturally arise in physical settings where dispersion dominates dissipation, notably hydrodynamics, nonlinear optics, plasma physics and Bose–Einstein condensates. The topic has traditionally been approached in different ways, from the perspective of modeling of physical phenomena, to that of the theory of partial differential equations, or as part of the theory of integrable systems.This monograph offers a thorough introduction to the topic, uniting the modeling, PDE and integrable systems approaches for the first time in book form. The presentation focuses on three "universal" families of physically relevant equations endowed with a completely integrable member: the Benjamin–Ono, Davey–Stewartson, and Kadomtsev–Petviashvili equations. These asymptotic models are rigorously derived and qualitative properties such as soliton resolution are studied in detail in both integrable andnon-integrable models. Numerical simulations are presented throughout to illustrate interesting phenomena.By presenting and comparing results from different fields, the book aims to stimulate scientific interactions and attract new students and researchers to the topic. To facilitate this, the chapters can be read largely independently of each other and the prerequisites have been limited to introductory courses in PDE theory.
E-bok
PDF, Engelska, 20221 977 kr
Läs direkt efter köp
Nonlinear Dispersive Equations are partial differential equations that naturally arise in physical settings where dispersion dominates dissipation, notably hydrodynamics, nonlinear optics, plasma physics and Bose–Einstein condensates. The topic has traditionally been approached in different ways, from the perspective of modeling of physical phenomena, to that of the theory of partial differential equations, or as part of the theory of integrable systems.This monograph offers a thorough introduction to the topic, uniting the modeling, PDE and integrable systems approaches for the first time in book form. The presentation focuses on three "universal" families of physically relevant equations endowed with a completely integrable member: the Benjamin–Ono, Davey–Stewartson, and Kadomtsev–Petviashvili equations. These asymptotic models are rigorously derived and qualitative properties such as soliton resolution are studied in detail in both integrable andnon-integrable models. Numerical simulations are presented throughout to illustrate interesting phenomena.
By presenting and comparing results from different fields, the book aims to stimulate scientific interactions and attract new students and researchers to the topic. To facilitate this, the chapters can be read largely independently of each other and the prerequisites have been limited to introductory courses in PDE theory.
Del 209 - Applied Mathematical Sciences
Nonlinear Dispersive Equations
Inverse Scattering and PDE Methods
Häftad, Engelska, 2023
996 kr
Skickas inom 5-8 vardagar
Nonlinear Dispersive Equations are partial differential equations that naturally arise in physical settings where dispersion dominates dissipation, notably hydrodynamics, nonlinear optics, plasma physics and Bose–Einstein condensates. The topic has traditionally been approached in different ways, from the perspective of modeling of physical phenomena, to that of the theory of partial differential equations, or as part of the theory of integrable systems.This monograph offers a thorough introduction to the topic, uniting the modeling, PDE and integrable systems approaches for the first time in book form. The presentation focuses on three "universal" families of physically relevant equations endowed with a completely integrable member: the Benjamin–Ono, Davey–Stewartson, and Kadomtsev–Petviashvili equations. These asymptotic models are rigorously derived and qualitative properties such as soliton resolution are studied in detail in both integrable andnon-integrable models. Numerical simulations are presented throughout to illustrate interesting phenomena.By presenting and comparing results from different fields, the book aims to stimulate scientific interactions and attract new students and researchers to the topic. To facilitate this, the chapters can be read largely independently of each other and the prerequisites have been limited to introductory courses in PDE theory.
Del 117 - Jahrbuch Fuer Internationale Germanistik - Reihe a
Legitimationsmechanismen Des Biographischen
Kontexte - Akteure - Techniken - Grenzen
Häftad, Tyska, 2016
1 013 kr
Skickas inom 5-8 vardagar
Häftad, Tyska, 2002
339 kr
Skickas inom 10-15 vardagar
Theoretisches Fundament zum biografischen Schreiben. Erstmals stellt der Band heraus, welche unterschiedlichen Konzepte dem Genre der Biografie in Literatur- und Geschichtswissenschaft, Soziologie sowie Psychologie zugrunde liegt. Darüber hinaus informiert er über praktische Aspekte, wie z.B. rechtliche Fragen, Neue Medien und biographische Werkstattberichte.
Häftad, Tyska, 2009
374 kr
Skickas inom 10-15 vardagar
Erzählen als grundlegende Form der Wirklichkeitserkenntnis und des sozialen Verhaltens. In vielen Bereichen des Alltags orientieren und verständigen wir uns mithilfe von Erzählungen. Der interdisziplinäre Band liefert einen systematischen Überblick über die wichtigsten Felder des nicht-literarischen Erzählens in Institutionen und im Alltag: z.B. Journalismus, Medizin, Psychologie, Recht, Religion und Wirtschaft.
Häftad, Tyska, 2016
285 kr
Skickas inom 10-15 vardagar
Diese Einführung liefert einen Überblick über die historisch-kulturellen, theoretischen und analytischen Dimensionen der Beschäftigung mit Comics und Graphic Novels. So informieren ausgewiesene Experten in Einzelbeiträgen etwa über medientheoretische Aspekte, Fragen der besonderen Produktion, Distribution und Rezeption von Comics, über zentrale Genres und ihre Klassiker und stellen ein handhabbares Instrumentarium zur Comic-Analyse vor. Abgerundet wird der Band durch Ausführungen zu Web-Comics und zu Institutionen der Comic-Forschung, durch ein Glossar und kommentierte Hinweise zur Fachliteratur. Mit Beiträgen von Julia Abel, Jochen Ecke, Barbara Eder, Christian Endres, Lukas Etter, Ole Frahm, Björn Hammel, Urs Hangartner, Matthias Harbeck, Christian Klein, Andreas C. Knigge, Stephan Köhn, Stephan Packard, Andreas Platthaus, Monika Schmitz-Emans, Marie Schröer, Daniel Stein, Ralph Trommer, Antonius Weixler, Lukas Werner
E-bok
PDF, Tyska, 2016347 kr
Läs direkt efter köp
Theoretisches Fundament zum biografischen Schreiben. Erstmals stellt der Band heraus, welche unterschiedlichen Konzepte dem Genre der Biografie in Literatur- und Geschichtswissenschaft, Soziologie sowie Psychologie zugrunde liegt. Darüber hinaus informiert er über praktische Aspekte, wie z.B. rechtliche Fragen, Neue Medien und biographische Werkstattberichte.
Häftad, Tyska, 2018
784 kr
Skickas inom 10-15 vardagar
Die Stimme Marcel Beyers zählt zu den wichtigsten in der deutschsprachigen Gegenwartsliteratur. Der Band unternimmt erstmals eine systematische Auseinandersetzung mit diesem ebenso ergiebigen wie qualitativ herausragenden Œuvre. Ausgewiesene Expertinnen und Experten widmen sich in vierzehn Einzelbeiträgen Beyers Lyrik und seinen Romanen, rücken bisher eher vernachlässigte Textgruppen (Essays, Libretti) in den Blick und diskutieren Beyers Poetik sowie die Rezeption seiner Texte. Damit ist der Band gleichermaßen als Einführung in das Werk Marcel Beyers wie für die vertiefende Auseinandersetzung mit einzelnen seiner Texte geeignet. Er ermöglicht einen Werküberblick, stellt gattungsübergreifend zentrale Themen sowie literarische Verfahren vor und setzt gleichzeitig neue Forschungsimpulse. Abgerundet wird der Band durch einen Originaltext Beyers sowie ein ausführliches Werkstattgespräch.
E-bok
PDF, Tyska, 2018769 kr
Läs direkt efter köp
Die Stimme Marcel Beyers zählt zu den wichtigsten in der deutschsprachigen Gegenwartsliteratur. Der Band unternimmt erstmals eine systematische Auseinandersetzung mit diesem ebenso ergiebigen wie qualitativ herausragenden Œuvre. Ausgewiesene Expertinnen und Experten widmen sich in vierzehn Einzelbeiträgen Beyers Lyrik und seinen Romanen, rücken bisher eher vernachlässigte Textgruppen (Essays, Libretti) in den Blick und diskutieren Beyers Poetik sowie die Rezeption seiner Texte. Damit ist der Band gleichermaßen als Einführung in das Werk Marcel Beyers wie für die vertiefende Auseinandersetzung mit einzelnen seiner Texte geeignet. Er ermöglicht einen Werküberblick, stellt gattungsübergreifend zentrale Themen sowie literarische Verfahren vor und setzt gleichzeitig neue Forschungsimpulse. Abgerundet wird der Band durch einen Originaltext Beyers sowie ein ausführliches Werkstattgespräch.
Inbunden, Tyska, 2018
784 kr
Skickas inom 10-15 vardagar
Zentraler Bestandteil der Erinnerungsdiskurse zum Ersten Weltkrieg sind jene Romane, Gedichte oder – historisch besonders wirkmächtig – Theaterstücke, die sich mit dem Kriegsgeschehen und dessen Auswirkungen auseinandersetzen. Der Band konzentriert sich auf die Verarbeitung des Kriegsgeschehens im deutschsprachigen und australischen Drama, weil dem Ersten Weltkrieg eine vergleichbar große Relevanz im jeweiligen Identitätsdiskurs zukommt, er aber gleichzeitig eine ganz unterschiedliche Akzentuierung erfährt. Die Weltkriegsdramatik erscheint vor diesem Hintergrund als idealer Gegenstand transnationaler komparatistischer Studien.
E-bok
PDF, Tyska, 2018763 kr
Läs direkt efter köp
Zentraler Bestandteil der Erinnerungsdiskurse zum Ersten Weltkrieg sind jene Romane, Gedichte oder – historisch besonders wirkmächtig – Theaterstücke, die sich mit dem Kriegsgeschehen und dessen Auswirkungen auseinandersetzen. Der Band konzentriert sich auf die Verarbeitung des Kriegsgeschehens im deutschsprachigen und australischen Drama, weil dem Ersten Weltkrieg eine vergleichbar große Relevanz im jeweiligen Identitätsdiskurs zukommt, er aber gleichzeitig eine ganz unterschiedliche Akzentuierung erfährt. Die Weltkriegsdramatik erscheint vor diesem Hintergrund als idealer Gegenstand transnationaler komparatistischer Studien.
E-bok
PDF, Tyska, 2009485 kr
Läs direkt efter köp
Erzählen als grundlegende Form der Wirklichkeitserkenntnis und des sozialen Verhaltens. In vielen Bereichen des Alltags orientieren und verständigen wir uns mithilfe von Erzählungen. Der interdisziplinäre Band liefert einen systematischen Überblick über die wichtigsten Felder des nicht-literarischen Erzählens in Institutionen und im Alltag: z.B. Journalismus, Medizin, Psychologie, Recht, Religion und Wirtschaft.
E-bok
PDF, Tyska, 2009803 kr
Läs direkt efter köp
Biographie als allgegenwärtiges Phänomen. Das Handbuch informiert über die verschiedenen Formen und Felder biographischen Erzählens und macht mit Merkmalen und Funktionen, mit Geschichte, regionalen Entwicklungen und kulturellen Traditionen der Biographik vertraut. Daneben stellt es biographisches Arbeiten als wissenschaftliche Methode in den Geistes-, Sozial- und Kulturwissenschaften sowie in der Medizin vor. Eine Einführung in die Analyse biographischen Erzählens und Antworten auf grundlegende Praxisfragen runden die disziplinenübergreifende Darstellung ab.
E-bok
PDF, Tyska, 2016335 kr
Läs direkt efter köp
Diese Einführung liefert einen Überblick über die historisch-kulturellen, theoretischen und analytischen Dimensionen der Beschäftigung mit Comics und Graphic Novels. So informieren ausgewiesene Experten in Einzelbeiträgen etwa über medientheoretische Aspekte, Fragen der besonderen Produktion, Distribution und Rezeption von Comics, über zentrale Genres und ihre Klassiker und stellen ein handhabbares Instrumentarium zur Comic-Analyse vor. Abgerundet wird der Band durch Ausführungen zu Web-Comics und zu Institutionen der Comic-Forschung, durch ein Glossar und kommentierte Hinweise zur Fachliteratur. Mit Beiträgen von Julia Abel, Jochen Ecke, Barbara Eder, Christian Endres, Lukas Etter, Ole Frahm, Björn Hammel, Urs Hangartner, Matthias Harbeck, Christian Klein, Andreas C. Knigge, Stephan Köhn, Stephan Packard, Andreas Platthaus, Monika Schmitz-Emans, Marie Schröer, Daniel Stein, Ralph Trommer, Antonius Weixler, Lukas Werner
Inbunden, Tyska, 2022
1 117 kr
Skickas inom 10-15 vardagar
Das Handbuch liefert einen Überblick über die verschiedenen Formen und Felder biographischen Erzählens. Es informiert systematisch und disziplinenübergreifend über Funktionen, Typen, Geschichte und kulturelle Traditionen der Biographik. Daneben wird biographisches Arbeiten als wissenschaftliche Methode in den Geistes-, Sozial- und Kulturwissenschaften bzw. in der Medizin vorgestellt. Schließlich werden Kategorien zur Analyse biographischen Erzählens eröffnet und grundlegende Praxis-Fragen (zu Konzeption, Umsetzung, Publikation, juristischen Aspekten) beantwortet. - Die 2. Auflage bringt 8 neue Texte zur Transnationalität, zu Comics und Graphic Novel, zur Objektbiographie, zum »Biographischen Paradox«, zu Digital Humanities und den Queer Studies, zur Metabiographik und zu den Tendenzen und Debatten der Gegenwart. Alle Artikel sind aktualisiert.
E-bok
Tyska, 20221 109 kr
Läs direkt efter köp
Das Handbuch liefert einen Überblick über die verschiedenen Formen und Felder biographischen Erzählens. Es informiert systematisch und disziplinenübergreifend über Funktionen, Typen, Geschichte und kulturelle Traditionen der Biographik. Daneben wird biographisches Arbeiten als wissenschaftliche Methode in den Geistes-, Sozial- und Kulturwissenschaften bzw. in der Medizin vorgestellt. Schließlich werden Kategorien zur Analyse biographischen Erzählens eröffnet und grundlegende Praxis-Fragen (zu Konzeption, Umsetzung, Publikation, juristischen Aspekten) beantwortet. - Die 2. Auflage bringt 8 neue Texte zur Transnationalität, zu Comics und Graphic Novel, zur Objektbiographie, zum »Biographischen Paradox«, zu Digital Humanities und den Queer Studies, zur Metabiographik und zu den Tendenzen und Debatten der Gegenwart. Alle Artikel sind aktualisiert.
Del 125 - Suhrkamp BasisBibliothek
Flughunde
Häftad, Tyska, 2012
170 kr
Skickas inom 3-6 vardagar
Häftad, Tyska, 2023
250 kr
Skickas inom 3-6 vardagar
Ist es Zufall, wenn Gespräche gelingen? Nein, ist es nicht! Das vorliegende Buch dient als Leitfaden, Gespräche punktgenau zu führen. Basis dafür ist das Kommunikationskonzept des zielorientierten Kurzgespräches. Das Buch führt in das Konzept ein und stellt die Methodik verständlich vor. Die Autor:innen erläutern das Vorgehen an Beispielen und für unterschiedliche Anwendungsbereiche. Besonderes Augenmerk gilt dabei den Fragen: Wie sind Gespräche auf den Punkt aufgebaut? Welche Haltung braucht es dazu? Welche Techniken sind nötig? Worauf ist das Augenmerk zu legen? Das Buch zeigt, wie es in kurzer Zeit gelingt, Lösungen zu finden und erste konkrete Schritte zu ermöglichen. Coaching- und Beratungssituationen kommen dabei ebenso in den Blick wie punktgenaues Agieren in Mitarbeitergesprächen, Meetings, Konferenzen und in digitaler Kommunikation. Ein Buch für alle, die besser kommunizieren und Gespräche erfolgreich auf den Punkt bringen möchten.
Inbunden, Engelska, 2018
1 902 kr
Skickas inom 5-8 vardagar
With its focus on drugs so recently introduced that they have yet to be found in any other textbooks or general references, the information and insight found here makes this a genuinely unique handbook and reference.Following the successful approach of the previous volumes in the series, inventors and primary developers of successful drugs from both industry and academia tell the story of the drug's discovery and describe the sometimes twisted route from the first drug candidate molecule to the final marketed drug. The 11 case studies selected describe recent drugs ranging across many therapeutic fields and provide a representative cross-section of present-day drug developments. Backed by plenty of data and chemical information, the insight and experience of today's top drug creators makes this one of the most useful training manuals that a junior medicinal chemist may hope to find.The International Union of Pure and Applied Chemistry has endorsed and sponsored this project because of its high educational merit.
Inbunden, Engelska, 2019
1 466 kr
Skickas inom 11-20 vardagar
Provides unique insider insight into the current drug development process, and what it takes to achieve success In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes twisted route from the first drug candidate molecule to the final marketed one. Beginning with a general section addressing overarching topics for drug discovery, the book offers seven chapters that feature selected case studies describing recently introduced drugs or drug classes. These include small molecule drugs as well as biopharmaceuticals and range across different therapeutic fields. Together, they provide a representative cross-section of the present-day drug development effort. Successful Drug Discovery: Volume 4 covers trends in peptide-based drug discovery and the physicochemical properties of recently approved oral drugs. The section on drug class studies looks at antibody-drug conjugates and the discovery, evolution, and therapeutic potential of dopamine partial agonists. Featured case studies examine the discovery of Etelcalcetide for the treatment of secondary hyper-parathyroidism in patients with chronic kidney disease; the development of Lenvatinib Mesylate; the discovery and development of Venetoclax; and more. -Focuses on recently introduced drugs that have not been featured in any textbooks or general references, including Ocrelizumab, a new generation of anti-CD-20 mAb for the treatment of multiple sclerosis, and Venetoclax, a selective antagonist of BCL-2 -Features personal experiences of successful drug developers from industry and academia -Endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Successful Drug Discovery: Volume 4 provides a fascinating and informative look into the process of drug discovery and would be a great reference for those in the pharmaceutical industry, organic and pharmaceutical chemists, and lecturers in pharmacy.
Inbunden, Engelska, 2021
1 427 kr
Skickas inom 11-20 vardagar
Filled with unique insights into current drugs that have made it to the marketplaceIn the fifth volume of Successful Drug Discovery, the inventors and primary developers of drugs that made it to the market tell the story of the drug�s discovery and development. Case studies of drugs from different therapeutic fields reveal the all-too-often unpredictable path from the first drug candidate molecule to the successfully marketed drug. In addition, this new volume addresses overarching topics for drug discovery, such as drug discovery in academia, and discusses currently important classes of small molecule as well as biological drugs. Comprehensive in scope, the book�s nine chapters provide a representative cross-section of the present-day drug development effort. The authoritative fifth volume is filled with relevant data and chemical information, as well as the insight and experience of the best contemporary drug creators. This important volume:- Puts the focus on recently introduced drugs that have not yet made it into standard textbooks or general references- Contains information and insight that is new and often not even available from the primary literature - Reveals what it takes to successfully develop a drug molecule that has made it all the way to the market - Is endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Written for medicinal chemists, pharmaceutical chemists, organic chemists, Successful Drug Discovery, Volume Five reveals the most recent techniques used by drug innovators in the drug development process.
Inbunden, Engelska, 2026
1 727 kr
Kommande
Drug developers share strategies for next-generation antibody-based cancer therapeuticsCancer immunotherapy has produced two transformative drug classes: bispecific antibodies and antibody-drug conjugates. Trends in Antibody Drug Discovery for Cancer Therapy brings together drug developers from pharmaceutical companies of all sizes to share their experiences developing these therapeutics. Christian Klein, whose Roche team contributed to twenty-four clinical stage bispecific antibodies, offers key insights into successful strategies for anticancer drug development.This book begins with a review of recent therapy developments in biological cancer treatment before examining bispecific antibodies and antibody-drug conjugates through detailed case studies of recently approved therapeutics. An international team of contributors then examine how bispecific antibodies target both cancer and immune cells, and how antibody-drug conjugates deliver cytotoxic payloads directly to tumors. The final section evaluates emerging approaches including antibody-based PROTACs and cytokine mimetics.Readers will also benefit from: Case studies documenting the development pathways of recently approved bispecific antibodies and antibody-drug conjugates from preclinical research through to clinical applicationAnalysis of targeted protein degradation strategies including antibody-based PROTACs and their potential for harnessing this mechanism in cancer therapyExpert evaluation of cytokine mimetics and other forward-looking approaches contributing to the next generation of antibody-based cancer treatmentsInsights from drug developers at both small and large pharmaceutical companies sharing past successes and future development plansDesigned for medicinal chemists, pharmaceutical chemists, and oncologists working in drug discovery and development, this volume addresses the unmet medical need for more efficient cancer therapeutics. Industry professionals will gain actionable insights for developing antibody-based drugs in a field that leads global pharmaceutical markets.
E-bok
Engelska, 20182 153 kr
Läs direkt efter köp
With its focus on drugs so recently introduced that they have yet to be found in any other textbooks or general references, the information and insight found here makes this a genuinely unique handbook and reference. Following the successful approach of the previous volumes in the series, inventors and primary developers of successful drugs from both industry and academia tell the story of the drug''s discovery and describe the sometimes twisted route from the first drug candidate molecule to the final marketed drug. The 11 case studies selected describe recent drugs ranging across many therapeutic fields and provide a representative cross-section of present-day drug developments. Backed by plenty of data and chemical information, the insight and experience of today''s top drug creators makes this one of the most useful training manuals that a junior medicinal chemist may hope to find. The International Union of Pure and Applied Chemistry has endorsed and sponsored this project because of its high educational merit.
E-bok
PDF, Engelska, 20182 231 kr
Läs direkt efter köp
With its focus on drugs so recently introduced that they have yet to be found in any other textbooks or general references, the information and insight found here makes this a genuinely unique handbook and reference. Following the successful approach of the previous volumes in the series, inventors and primary developers of successful drugs from both industry and academia tell the story of the drug''s discovery and describe the sometimes twisted route from the first drug candidate molecule to the final marketed drug. The 11 case studies selected describe recent drugs ranging across many therapeutic fields and provide a representative cross-section of present-day drug developments. Backed by plenty of data and chemical information, the insight and experience of today''s top drug creators makes this one of the most useful training manuals that a junior medicinal chemist may hope to find. The International Union of Pure and Applied Chemistry has endorsed and sponsored this project because of its high educational merit.
E-bok
PDF, Engelska, 20191 909 kr
Läs direkt efter köp
Provides unique insider insight into the current drug development process, and what it takes to achieve success In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes twisted route from the first drug candidate molecule to the final marketed one. Beginning with a general section addressing overarching topics for drug discovery, the book offers seven chapters that feature selected case studies describing recently introduced drugs or drug classes. These include small molecule drugs as well as biopharmaceuticals and range across different therapeutic fields. Together, they provide a representative cross-section of the present-day drug development effort. Successful Drug Discovery: Volume 4 covers trends in peptide-based drug discovery and the physicochemical properties of recently approved oral drugs. The section on drug class studies looks at antibody-drug conjugates and the discovery, evolution, and therapeutic potential of dopamine partial agonists. Featured case studies examine the discovery of Etelcalcetide for the treatment of secondary hyper-parathyroidism in patients with chronic kidney disease; the development of Lenvatinib Mesylate; the discovery and development of Venetoclax; and more. -Focuses on recently introduced drugs that have not been featured in any textbooks or general references, including Ocrelizumab, a new generation of anti-CD-20 mAb for the treatment of multiple sclerosis, and Venetoclax, a selective antagonist of BCL-2 -Features personal experiences of successful drug developers from industry and academia -Endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Successful Drug Discovery: Volume 4 provides a fascinating and informative look into the process of drug discovery and would be a great reference for those in the pharmaceutical industry, organic and pharmaceutical chemists, and lecturers in pharmacy.
E-bok
Engelska, 20191 978 kr
Läs direkt efter köp
Provides unique insider insight into the current drug development process, and what it takes to achieve success In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes twisted route from the first drug candidate molecule to the final marketed one. Beginning with a general section addressing overarching topics for drug discovery, the book offers seven chapters that feature selected case studies describing recently introduced drugs or drug classes. These include small molecule drugs as well as biopharmaceuticals and range across different therapeutic fields. Together, they provide a representative cross-section of the present-day drug development effort. Successful Drug Discovery: Volume 4 covers trends in peptide-based drug discovery and the physicochemical properties of recently approved oral drugs. The section on drug class studies looks at antibody-drug conjugates and the discovery, evolution, and therapeutic potential of dopamine partial agonists. Featured case studies examine the discovery of Etelcalcetide for the treatment of secondary hyper-parathyroidism in patients with chronic kidney disease; the development of Lenvatinib Mesylate; the discovery and development of Venetoclax; and more. -Focuses on recently introduced drugs that have not been featured in any textbooks or general references, including Ocrelizumab, a new generation of anti-CD-20 mAb for the treatment of multiple sclerosis, and Venetoclax, a selective antagonist of BCL-2 -Features personal experiences of successful drug developers from industry and academia -Endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Successful Drug Discovery: Volume 4 provides a fascinating and informative look into the process of drug discovery and would be a great reference for those in the pharmaceutical industry, organic and pharmaceutical chemists, and lecturers in pharmacy.