Dieter Steinhilber - Böcker

Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygenase metabolites are involved in host defence reactions, cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease and cancer. This PIR volume summarizes the physiological and pathophysiological functions of lipoxygenases.

Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology.

This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods.With its examination of these novel methods and generous practical advice, this is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.