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    1. Medicin
    2. Andra medicinska specialiteter
    3. Farmakologi

    Molecular Biology in Medicinal Chemistry

    AvTheodor Dingermann,Theodor Dingermann

    Inbunden, Engelska, 2004

    Del 21 i serien Methods & Principles in Medicinal Chemistry

    2 744 kr

    Beställningsvara. Skickas inom 5-8 vardagar. Fri frakt över 249 kr.

    Beskrivning

    This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods.With its examination of these novel methods and generous practical advice, this is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.

    Produktinformation

    • Utgivningsdatum:2004-01-29
    • Mått:178 x 246 x 25 mm
    • Vikt:984 g
    • Format:Inbunden
    • Språk:Engelska
    • Serie:Methods & Principles in Medicinal Chemistry
    • Antal sidor:435
    • Upplaga:1
    • Förlag:Wiley-VCH Verlag GmbH
    • ISBN:9783527304318

    Utforska kategorier

    • Farmakologi inom Medicin
    • Kemi inom Naturvetenskap och teknik
    • Biologi inom Naturvetenskap och teknik

    Mer om författaren

    Theodor Dingermann, born 1948, studied pharmacy at the University of Erlangen, Germany. After obtaining his PhD in biochemistry, he worked as a post-doc at Yale University, New Haven. In 1987 he completed his habilitation for the disciplines of biochemistry and molecular biology. Since 1990 he is full professor of pharmaceutical biology at Goethe University in Frankfurt, Germany. He is editor-in-chief of two journals, "Die Pharmazie" and "Pharmazie in unserer Zeit". Furthermore, he is chairman of the working group on biopharmaceuticals and vice-chairman of the committee on pharmaceutical biology of the German Arzneibuch commission. From 2000 to 2004 he has been President of the German Pharmaceutical Society. Dieter Steinhilber, born 1959, studied pharmacy at the University of Tubingen (Germany). After an assistantship there he spent a postdoc period with Nobel prize winner Bengt Samuelsson in Stockholm (Sweden). In 1994 he received an associate professorship and since 2000 he is a full professor for pharmaceutical chemistry at the Goethe University in Frankfurt (Germany). He is also the chairman of the scientific advisory board of Phenion, a company for molecular cell physiology. Gerd Folkers is professor of pharmaceutical chemistry at the ETH Zurich since 1991. He studied pharmacy at the University of Bonn and earned his Ph.D. on structure-activity relationships of desapurines. He then moved to the University of Tubingen, where he completed his habilitation in pharmaceutical chemistry. During a stay with H.-D. Hoeltje in Bern, he studied new research methods in computer-aided molecular design and expanded this knowledge during other stays with T. Blundell at the Birkbeck College and E. Meyer at Texas A&M University.The focus of his research is the molecular interaction between drugs and their binding sites. Besides his work on the molecular mechanism of "conventional" nucleoside therapeutics against virus infections and cancer, his special interest has shifted to immuno-therapeutics.

    Recensioner i media

    "...a welcome addition to the library of anyone seeking to build a multidisciplinary group" Applied Organometallic Chemistry, June 2004 "In all, the book touches on some of the trendiest subjects that interface to form the frontier of modern medicinal chemistry." Kevin G. Rice, Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Journal of Medicinal Chemistry, Vol. 47, No. 26, 2004

    Innehållsförteckning

    • MOLECULAR TARGETSCellular Assays in Drug DiscoveryGene Knockout ModelsReporter Gene Assay Systems for the Investigation of GPCRsFrom the Human Genome to New Drugs: The Potential of Orphan GPCRsSYNTHESISStereoselective Synthesis with the Help of Recombinant EnzymesNucleic Acid DrugsANALYSISRecent Trends in Enantioseparation of Chiral DrugsAffinity ChromatographyNMR-based Drug Discovery13C- and 15N-Isotopic Labeling of ProteinsAntibody Fragments as Crystallization EnhancersKINETICS, METABOLISM AND TOXICOLOGYPharmacogenetics: The Effect of Inherited Genetic Variation on Drug Disposition and Drug ResponsePharmacogenomics of Bioavaliability and EliminationToxicogenomics: Integration of New Molecular Biological Tools in Toxicology