Methods & Principles in Medicinal Chemistry – serie
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33 produkter
Molecular Biology in Medicinal Chemistry
Av Theodor Dingermann, Theodor Dingermann m. fl.
Inbunden, 2004
2744 kr
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This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods.With its …
Prodrugs and Targeted Delivery
Towards Better ADME Properties
Av Jarkko Rautio, Jarkko Rautio
Inbunden, 2010
2291 kr
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This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at …
Pharmacokinetics and Metabolism in Drug Design
Av Dennis A. Smith, Dennis A. Smith m. fl.
Inbunden, 2012
1704 kr
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In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics …
Protein-Protein Interactions in Drug Discovery
Inbunden, 2013
1945 kr
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Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of …
Phosphodiesterases and Their Inhibitors
Av Spiros Liras, Spiros Liras m. fl.
Inbunden, 2014
1825 kr
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Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug.Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are …
Lead Generation, 2 Volume Set
Methods and Strategies
Av Jörg Holenz
Inbunden, 2016
3147 kr
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In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generation. This is the first book to combine both standard and innovative approaches in comparable breadth …
Antitargets and Drug Safety
Av Laszlo Urban, Laszlo Urban m. fl.
Inbunden, 2015
2011 kr
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With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future.Divided into three major parts, the first section deals with novel technologies and includes the utility of …
Drug Selectivity
An Evolving Concept in Medicinal Chemistry
Av Norbert Handler, Norbert Handler
Inbunden, 2018
2225 kr
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The book "Drug Selectivity - An Evolving Concept in Medicinal Chemistry" provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process.The result is a broad survey of current and …
Fragment-based Drug Discovery
Lessons and Outlook
Av Daniel A. Erlanson, Daniel A. Erlanson m. fl.
Inbunden, 2016
2011 kr
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From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current …
Neglected Tropical Diseases
Drug Discovery and Development
Av David C. Swinney, Michael P. Pollastri
Inbunden, 2019
1940 kr
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A drug discovery reference to the crippling tropical diseases that affect more than 1 billion people. Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization?s list of neglected tropical diseases. The authors?all are experts on the …
Epigenetic Drug Discovery
Av Wolfgang Sippl, Manfred Jung
Inbunden, 2019
2291 kr
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This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins.Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, …
New Drug Development for Known and Emerging Viruses
Av Helga Rübsamen-Schaeff, Helga Rübsamen-Schaeff m. fl.
Inbunden, 2021
2296 kr
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Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decadesWritten by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and …
Target Discovery and Validation
Methods and Strategies for Drug Discovery
Inbunden, 2019
1760 kr
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The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With …
Solid State Development and Processing of Pharmaceutical Molecules
Salts, Cocrystals, and Polymorphism
Av Michael Gruss, Michael Gruss
Inbunden, 2021
2296 kr
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Solid State Development and Processing of Pharmaceutical Molecules A guide to the lastest industry principles for optimizing the production of solid state active pharmaceutical ingredients Solid State Development and Processing of Pharmaceutical Molecules is an authoritative guide that covers the …
Flow and Microreactor Technology in Medicinal Chemistry
Inbunden, 2022
1619 kr
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Learn to master a powerful technology to enable a faster drug discovery workflow The ultimate dream for medicinal chemists is the ability to synthesize new drug-like compounds with the push of a button. The key to synthesizing chemical compounds more quickly and accurately lies in …
Targeted Drug Delivery
Av Yogeshwar Bachhav, Yogeshwar Bachhav
Inbunden, 2022
1940 kr
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Targeted Drug Delivery Novel approaches in targeted drug delivery for both small molecule and biopharmaceutical drugs Targeted Drug Delivery explores a new frontier in drug research that has become a focus for developing novel medications. The work discusses a wide range of approaches for targeting …
Open Access Databases and Datasets for Drug Discovery
Av Antoine Daina, Michael Przewosny m. fl.
Inbunden, 2023
2007 kr
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Open Access Databases and Datasets for Drug Discovery Timely resource discussing the future of data-driven drug discovery and the growing number of open-source databases With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open …
RNA as a Drug Target
The Next Frontier for Medicinal Chemistry
Av John Schneekloth, John Schneekloth m. fl.
Inbunden, 2024
1628 kr
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Discover a new paradigm in drug discovery that greatly expands the space of addressable drug targets and potential novel drugsExisting paradigms for drug discovery have focused largely on enzymes and other proteins as drug targets. In recent years, however, different varieties of ribonucleic acids …
Drug Development Approaches for Poorly Soluble Compounds
Inbunden, 2026
1713 kr
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Ten proven strategies to overcome solubility challenges in drug development Poor water solubility prevents drug candidates from reaching their therapeutic targets, causing promising compounds to fail during development. Drug Development Approaches for Poorly Soluble Compounds presents ten distinct …
Combinatorial Chemistry
From Theory to Application
Av Series Editor:Raimund Mannhold, Series Editor:Hug Kubinyi m. fl.
Inbunden, 2006
2897 kr
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The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis.A new chapter on screening complements the overview of combinatorial strategy and synthetic methods. "Experimental details and complete reaction data [...] …
Chirality in Drug Research
Av Eric Francotte, Editor:Eric Francotte m. fl.
Inbunden, 2006
2301 kr
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Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have …
Mass Spectrometry in Medicinal Chemistry
Applications in Drug Discovery
Av Editor:Klaus Wanner, Editor:Georg Hofner m. fl.
Inbunden, 2007
2355 kr
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This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in …
Molecular Descriptors for Chemoinformatics, 2 Volume Set
Volume I: Alphabetical Listing / Volume II: Appendices, References
Av Roberto Todeschini, Viviana Consonni
Inbunden, 2009
4283 kr
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Molecular Descriptors for Chemoinformatics As every chemist knows, there is a direct (if complex) relationship between the molecular structure of a compound and its chemical behavior. Predicting such behavior is possible by an abstract representation of its structure in terms of chemical similarity …
Drug Bioavailability
Estimation of Solubility, Permeability, Absorption and Bioavailability
Av Han Van de Waterbeemd, Han van de Waterbeemd m. fl.
Inbunden, 2008
2415 kr
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Drug Bioavailability In order to reach its intended site of action, the drug molecules in every pill that we swallow must first be absorbed, transported via the bloodstream and evade various mechanisms that eliminate drugs from the body. Those drug properties that determine, for example, its …
Hit and Lead Profiling
Identification and Optimization of Drug-like Molecules
Av Bernard Faller, Laszlo Urban
Inbunden, 2009
2235 kr
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The only reference on current methods to generate pharmacokinetic and safety profiles of drug candidates, as well as how they must be balanced against one other for the best selection of candidates for further development.Following a brief introduction to the necessities of filtering and risk …
Virtual Screening
Principles, Challenges, and Practical Guidelines
Inbunden, 2011
1813 kr
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Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction can be tested by computer …
Protein-Ligand Interactions
Inbunden, 2012
1632 kr
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Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential fordevelopment. The first part provides a basic understanding of the factors governing protein-ligand interactions, followed by a comparison of key experimental …
Bioisosteres in Medicinal Chemistry
Av Nathan Brown
Inbunden, 2012
1495 kr
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Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first …
Natural Products in Medicinal Chemistry
Inbunden, 2014
1743 kr
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The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the …
Transporters as Drug Targets
Av Gerhard F. Ecker, Rasmus P. Clausen m. fl.
Inbunden, 2017
1392 kr
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As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets.Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their …
