Erling Norrby – författare

Textbook of Medical Virology presents a critical review of general principles in the field of medical virology. It discusses the description and molecular structures of virus. It addresses the morphology and classifications of viruses. It also demonstrates the principal aspects of virus particle structure. Some of the topics covered in the book are the symmetrical arrangements of viruses; introduction to different families of animal viruses; biochemistry of virus particles; the immunological properties and biological activities of viral gene products; description of enzymatic activities of viruses; and haemagglutination, cell fusion, and haemolysis of viruses. The description and characteristics of viral antigens are covered. The identification and propagation of viruses in tissue and cell cultures are discussed. An in-depth analysis of the principles of virus replication is provided. A study of the morphogenesis of virions is also presented. A chapter is devoted to virus-induced changes of cell structures and functions. The book can provide useful information to virologists, microbiologists, students, and researchers.

The present book discusses the Nobel Prizes in physiology or medicine from 1969 to 1971. The 1969 prize recognized Max Delbrück, Alfred Hershey and Salvador Luria. Their pioneering studies of viruses infecting bacteria, bacteriophages, from the mid-1940s through the 1950s laid the foundation for the wide field of molecular biology. The nature of the gene was finally understood. Insights into the biochemistry of the critical information molecules, the nucleic acids, opened wide vistas for interpreting their expression and the interaction of their product with other gene products.The contact between the endings of a nerve and a target cell, the synapse, has always stirred the imagination of scientists. A number of the insights gained have been highlighted by Nobel Prizes in physiology or medicine. In 1970 the prize recognized Bernard Katz, Ulf von Euler and Julius Axelrod. They had revealed how signaling substances in the nerve terminals were stored in packages, released by membrane fusion and inactivated or reused by particular metabolic events.The recipient of the 1971 Nobel Prize in physiology or medicine was a single scientist, Earl Sutherland. He had identified critical molecules in cells that allow signals elicited at their surface via a number of internal steps to influence the expression of specific genes in the nucleus. The new kind of information transmitting molecules were referred to as "secondary messengers". They represent a critical part of a highly complex network of signaling controlling the operative conditions of the cell by adjustments of the so-called intermediary metabolism.The widening insights into functions of specialized cells and their complex interactions have led to the development of many kinds of remedies.

The present book discusses the Nobel Prizes in physiology or medicine from 1969 to 1971. The 1969 prize recognized Max Delbrück, Alfred Hershey and Salvador Luria. Their pioneering studies of viruses infecting bacteria, bacteriophages, from the mid-1940s through the 1950s laid the foundation for the wide field of molecular biology. The nature of the gene was finally understood. Insights into the biochemistry of the critical information molecules, the nucleic acids, opened wide vistas for interpreting their expression and the interaction of their product with other gene products.The contact between the endings of a nerve and a target cell, the synapse, has always stirred the imagination of scientists. A number of the insights gained have been highlighted by Nobel Prizes in physiology or medicine. In 1970 the prize recognized Bernard Katz, Ulf von Euler and Julius Axelrod. They had revealed how signaling substances in the nerve terminals were stored in packages, released by membrane fusion and inactivated or reused by particular metabolic events.The recipient of the 1971 Nobel Prize in physiology or medicine was a single scientist, Earl Sutherland. He had identified critical molecules in cells that allow signals elicited at their surface via a number of internal steps to influence the expression of specific genes in the nucleus. The new kind of information transmitting molecules were referred to as "secondary messengers". They represent a critical part of a highly complex network of signaling controlling the operative conditions of the cell by adjustments of the so-called intermediary metabolism.The widening insights into functions of specialized cells and their complex interactions have led to the development of many kinds of remedies.

The present book discusses the prizes in physiology or medicine 1963-65. The 1963 prize recognized milestone discoveries in the field of neurosciences, the way electrical impulses are generated and spread in nerves. The impressive developments of insights into tantalizing brain functions, like consciousness and memory, is discussed in the perspective of prizes both before and after the 1963 prize. The prize in 1964 marked the advanced biochemical venture that led to a full understanding of the synthesis of cholesterol, a central molecule for providing flexibility of the membranes of the trillions of cell in our body. The importance of this molecule for the appearance of cardiovascular diseases and the possibilities to prevent them is presented in the light of other prizes earlier and later in this field. The 1965 prize recognized three impressive French intellectuals, Lwoff, Monod and Jacob. Their contributions allowed the full maturation of the initial phase of the emerging field of molecular biology. The comprehension of the information flow from DNA via RNA to proteins was the source of a revolution of life sciences and of medicine.

The present book discusses the prizes in physiology or medicine 1963–65. The 1963 prize recognized milestone discoveries in the field of neurosciences, the way electrical impulses are generated and spread in nerves. The impressive developments of insights into tantalizing brain functions, like consciousness and memory, is discussed in the perspective of prizes both before and after the 1963 prize. The prize in 1964 marked the advanced biochemical venture that led to a full understanding of the synthesis of cholesterol, a central molecule for providing flexibility of the membranes of the trillions of cell in our body. The importance of this molecule for the appearance of cardiovascular diseases and the possibilities to prevent them is presented in the light of other prizes earlier and later in this field. The 1965 prize recognized three impressive French intellectuals, Lwoff, Monod and Jacob. Their contributions allowed the full maturation of the initial phase of the emerging field of molecular biology. The comprehension of the information flow from DNA via RNA to proteins was the source of a revolution of life sciences and of medicine.

In a relatively brief but masterful recounting, Professor Ulf Lagerkvist traces the origins and seminal developments in the field of chemistry, highlighting the discoveries and personalities of the individuals who transformed the ancient myths of the Greeks, the musings of the alchemists, the mystique of phlogiston into the realities and the laws governing the properties and behavior of the elements; in short, how chemistry became a true science. A centerpiece of this historical journey was the triumph by Dmitri Mendeleev who conceived the Periodic Law of the Elements, the relation between the properties of the elements and their atomic weights but more precisely their atomic number. Aside from providing order to the elements known at the time, the law predicted the existence and atomic order of elements not then known but were discovered soon after.An underlying but explicit intent of Lagerkvist's survey is to address what he believes was a gross injustice in denying Mendeleev the Nobel Prize in Chemistry in 1905 and again in 1906. Delving into the Royal Swedish Academy of Sciences' detailed records concerning the nominations, Lagerkvist reveals the judging criteria and the often heated and prejudicial arguments favoring and demeaning the contributions of the competing contenders of those years. Lagerkvist, who was a member of the Swedish Academy of Sciences and has participated in judging nominations for the chemistry prize, concludes “It is in the nature of the Nobel Prize that there will always be a number candidates who obviously deserve to be rewarded but never get the accolade” — Mendeleev was one of those.

The Nobel Prizes in natural sciences have developed to become a unique measure of scientific excellence. Using archival documents, which have been released (50 years secrecy) for scholarly work, the author expertly traces the strengths and weaknesses of the Nobel system as exemplified by individual prizes. Surveys of the more than 100 years that the Prizes have been awarded are also presented.This book discusses the most important prize in the world of science and gives unique historical insights into how the laureate selection process has developed to secure optimal choice.No other book has been published which draws from previously classified archival materials to the extent that this book does. It indirectly deals with factors that foster scientific discoveries viz. the role of both individuals and institutions and thus provides invaluable insights for researchers, institutions and anyone interested in science.

The Nobel Prizes in natural sciences have developed to become a unique measure of scientific excellence. Using archival documents, which have been released (50 years secrecy) for scholarly work, the author expertly traces the strengths and weaknesses of the Nobel system as exemplified by individual prizes. Surveys of the more than 100 years that the Prizes have been awarded are also presented.This book discusses the most important prize in the world of science and gives unique historical insights into how the laureate selection process has developed to secure optimal choice.No other book has been published which draws from previously classified archival materials to the extent that this book does. It indirectly deals with factors that foster scientific discoveries viz. the role of both individuals and institutions and thus provides invaluable insights for researchers, institutions and anyone interested in science.

Each year the Nobel Prizes in the natural sciences reveal amazing discoveries. New milestones in the relentless advance of science are identified. The growth of knowledge and its evolution can be researched in the Nobel archives where nominations are kept secret for 50 years after the awards have been made. They represent a treasure for real-time assessment of science. Norrby's earlier book, Nobel Prizes and Life Sciences (2010) examined the unique archival records until 1959.The present book takes us up to 1962, surveying a range of dazzling discoveries. All prizes in immunology are reviewed. Their impact on our capacity to control infectious diseases and transplant organs are highlighted. The Nobel year 1962 is exceptional in recognizing the most major advance in biology since Darwin in 1859 presented his theory of evolution. This was the dramatic discovery of the double-helix structure of DNA by Watson and Crick in 1953. The era of molecular biology had begun. Its explosive development continues into the present.

Each year the Nobel Prizes in the natural sciences reveal amazing discoveries. New milestones in the relentless advance of science are identified. The growth of knowledge and its evolution can be researched in the Nobel archives where nominations are kept secret for 50 years after the awards have been made. They represent a treasure for real-time assessment of science. Norrby's earlier book, Nobel Prizes and Life Sciences (2010) examined the unique archival records until 1959.The present book takes us up to 1962, surveying a range of dazzling discoveries. All prizes in immunology are reviewed. Their impact on our capacity to control infectious diseases and transplant organs are highlighted. The Nobel year 1962 is exceptional in recognizing the most major advance in biology since Darwin in 1859 presented his theory of evolution. This was the dramatic discovery of the double-helix structure of DNA by Watson and Crick in 1953. The era of molecular biology had begun. Its explosive development continues into the present.

The present book offers an in-depth analysis of the Nobel Prize in chemistry in 1972 and the Nobel Prizes in physiology or medicine (1972–74) using the unique Nobel archive materials that can become available by permission after 50 years of secrecy. The perspective by the author is unique for the years 1973–74, since he himself was an adjunct member of the Nobel Prize committee at the Karolinska Institute during these years and he participated in providing the recommendation to the Medical Faculty, which took the final decision.The Nobel Prize in chemistry in 1972 recognized the insights gained into the central problem of protein folding. The prize was split with one half to Christian B. Anfinsen and the other half to Stanford Moore and William H Stein. Over time, important further insights have been gained into this important field of research as discussed in the book. As late as 2024 another Nobel Prize in chemistry "for computational protein design" was awarded to two scientists from the UK and one from the USA. The prize in physiology or medicine in 1972 recognized the important characterization of the structure of immunoglobulin G by Gerald M. Edelman and Rodney R. Porter. Their work provided a foundation for many subsequent Nobel Prizes in physiology or medicine, recognizing the importance of several critical discoveries in the complex and important field of immunology.The Nobel Prize in physiology or medicine in 1973 was exceptional. It recognized the founding fathers of the field of animal behavior (ethology), Karl von Frisch, Konrad Lorenz and Nikolaas Tinbergen. It was concluded at the time that insights gained in this field were of potential value for the development of psychiatric care of patients in human medicine.Finally, the 1974 Nobel prize in physiology or medicine recognized the founding fathers of the science of architecture of cells. The scientists Albert Claude, Christian de Duve and George E Palade pioneered cell biology studies during the 1950s and 1960s at The Rockefeller Institute (later The Rockefeller University). Insights into the detailed structure of the multitude of cellular organelles and the consequential possibilities to determine their unique biochemical structures have revolutionized the understanding of the way cells operate and hence given insights into functional errors that may lead to diseases.

The present book offers an in-depth analysis of the Nobel Prize in chemistry in 1972 and the Nobel Prizes in physiology or medicine (1972-74) using the unique Nobel archive materials that can become available by permission after 50 years of secrecy. The perspective by the author is unique for the years 1973-74, since he himself was an adjunct member of the Nobel Prize committee at the Karolinska Institute during these years and he participated in providing the recommendation to the Medical Faculty, which took the final decision.The Nobel Prize in chemistry in 1972 recognized the insights gained into the central problem of protein folding. The prize was split with one half to Christian B. Anfinsen and the other half to Stanford Moore and William H Stein. Over time, important further insights have been gained into this important field of research as discussed in the book. As late as 2024 another Nobel Prize in chemistry "for computational protein design" was awarded to two scientists from the UK and one from the USA. The prize in physiology or medicine in 1972 recognized the important characterization of the structure of immunoglobulin G by Gerald M. Edelman and Rodney R. Porter. Their work provided a foundation for many subsequent Nobel Prizes in physiology or medicine, recognizing the importance of several critical discoveries in the complex and important field of immunology.The Nobel Prize in physiology or medicine in 1973 was exceptional. It recognized the founding fathers of the field of animal behavior (ethology), Karl von Frisch, Konrad Lorenz and Nikolaas Tinbergen. It was concluded at the time that insights gained in this field were of potential value for the development of psychiatric care of patients in human medicine.Finally, the 1974 Nobel prize in physiology or medicine recognized the founding fathers of the science of architecture of cells. The scientists Albert Claude, Christian de Duve and George E Palade pioneered cell biology studies during the 1950s and 1960s at The Rockefeller Institute (later The Rockefeller University). Insights into the detailed structure of the multitude of cellular organelles and the consequential possibilities to determine their unique biochemical structures have revolutionized the understanding of the way cells operate and hence given insights into functional errors that may lead to diseases.

The present book discusses the Nobel Prizes in physiology or medicine 1966-68. The 1966 prize recognized that viruses may be involved in cancer formation. Later studies revealed that these kinds of infectious agents could pick up and transmit cellular genes of importance for regulation of cellular growth. It was then possible to recognize that many genes of this kind could be involved in the formation of cancer. The disease was found to represent the dark side of evolution. As a consequence of this insight new means of treatment fortunately have been developed.The rear parts of the eyes are extensions of the central nervous system. They have a fascinating intrinsic complexity, the neurophysiology and biochemistry of which has been progressively analyzed. These revealing studies concern both our capacity to distinguish different colors and also our possibility to see in the dark. The Prize in 1967 identified seminal contributions in this wide field by Ragnar Granit, Haldan Hartline and George Wald.The 1968 Prize is distinct in its recognition of Robert Holley, Ghobind Khorana and Marshall Nirenberg, who in different ways had contributed to the cracking of the genetic code. Insights into the language used by Nature, since the dawn of cellular life some 4.6 billion years ago, have completely revolutionized modern life sciences. The capacity to read and also to write the books of life has defined new kinds of science, deepening our understanding of the magic of evolution and opened the possibilities for molecular medicine by understanding the genetic background to diseases, not least cancer.Related Link(s)