Ghassan S. Kassab – författare

This book portrays the commonality of tissue micro-structure that dictates physiological function in various organs (microstructure-function relation). Tissue and organ models are used to illustrate physiological functions based on microstructure. Fiber scale properties such as orientation and crimp are described in detail. Structurally-based constitutive models are given throughout the book, not only to avoid ambiguities in material characterization, but also to offer insights into the function, structure, and mechanics of tissue components. A statement of future directions of the field is also given, including how advancements, such as state-of-the-art computational modeling and optical measurements of tissue/cells structures, are taking structure-based modeling to the next level.

This book also:

Provides a comprehensive view of tissue modeling across multiple systems

Broadens readers’ understanding of state-of-the-art computational modeling and optical measurements of tissue/cells structures

Describes in detail fiber scale properties such as orientation and crimp

This comprehensive text examines both global and local coronary blood flow based on morphometry and mechanical properties of the coronary vasculature. Using a biomechanical approach, this book addresses coronary circulation in a quantitative manner based on models rooted in experimental data that account for the various physical determinants of coronary blood flow including myocardial-vessel interactions and various mechanisms of autoregulation. This is the first text dedicated to a distributive analysis (as opposed to lumped) and provides digital files for detailed anatomical data (e.g., diameters, lengths, node-to-node connections) of the coronary vessels. This book also provides appendices with specific mathematical formulations for the biomechanical analyses and models in the text. Written by Dr. Ghassan S. Kassab, a leader in the field of coronary biomechanics, Coronary Circulation: Anatomy, Mechanical Properties, and Biomechanics is a synthesis of seminal topics in the field and is intended for clinicians, bioengineers, and researchers as a compendium on the topic. The detailed anatomical and mechanical data provided are intended to be used as a platform to address new questions in this exciting and clinically very important research area.

This book covers mechanobiology, growth, remodeling, and clinical implications of coronary artery disease treatment. This volume presents a comprehensive overview of coronary circulation, including growth and remodeling of coronary vasculature, implications to cardiology, and implications to cardiovascular surgery. General principles of biomechanical homeostasis and mechanobiology are outlined. Specifics topics covered include endothelial mechano-transduction, flow reversal, uniform shear, stress & strain hypotheses, scaling laws in coronary artery disease, growth, and aging, and coronary retroperfusion.

Coronary Circulation: Mechanobiology, Growth, Remodeling and Clinical Implications is a vital resource for coronary physiologists and cardiovascular disease researchers and bioengineers who want to learn more about mechanobiology and clinical implications to coronary circulation in health and disease.