J.A.E Spaan - Böcker

Various disciplines have been bene?ted by the advent of high-performance computing in achieving practical solutions to their problems and the area of health care is no exception to this. Signal processing and data mining tools have been developed to enhance the computational capabilities so as to help clinicians in diagnosis and treatment. The electrocardiogram (ECG) is a representative signal containing inf- mation about the condition of the heart. The shape and size of the P-QRS-T wave and the time intervals between various peaks contains useful infor- tion about the nature of disease a?icting the heart. However, the human - server cannot directly monitor these subtle details. Besides, since biosignals are highly subjective, the symptoms may appear at random in the timescale. The presence of cardiac abnormalities are generally re?ected in the shape of ECG waveform and heart rate. However, by the very nature of biosignals, this re?ection would be random in the timescale. That is, the diseases may not show up all the time, but would manifest at certain irregular (random) intervals during the day. Therefore the study of ECG pattern and heart rate variability has to be carried out over extended periods of time (i. e. , for 24 hours). Naturally the volume of the data to be handled is enormous and its study is tedious and time consuming. As a consequence, the possibility of the analyst missing (or misreading) vital information is high.

The development of a bio-engineered pacemaker is of substantial clinical and also scientific interest because it promises to overcome several limitations of electronic pacemakers. Moreover it may answer the longstanding question of whether the complex structure of the sinus node is indeed a prerequisite for reliable pacemaking, or simpler structures might work as well.This book gives an overview of the current state-of-the-art of creating a bio-engineered pacemaker. It shows the approaches to develop of genetic and cell-based engineering methods suitable to implement them with safety and stability. It also illuminates the problems that need to be solved before bio-pacemaking can be considered for clinical use.

Various disciplines have been bene?ted by the advent of high-performance computing in achieving practical solutions to their problems and the area of health care is no exception to this. Signal processing and data mining tools have been developed to enhance the computational capabilities so as to help clinicians in diagnosis and treatment. The electrocardiogram (ECG) is a representative signal containing inf- mation about the condition of the heart. The shape and size of the P-QRS-T wave and the time intervals between various peaks contains useful infor- tion about the nature of disease a?icting the heart. However, the human - server cannot directly monitor these subtle details. Besides, since biosignals are highly subjective, the symptoms may appear at random in the timescale. The presence of cardiac abnormalities are generally re?ected in the shape of ECG waveform and heart rate. However, by the very nature of biosignals, this re?ection would be random in the timescale. That is, the diseases may not show up all the time, but would manifest at certain irregular (random) intervals during the day. Therefore the study of ECG pattern and heart rate variability has to be carried out over extended periods of time (i. e. , for 24 hours). Naturally the volume of the data to be handled is enormous and its study is tedious and time consuming. As a consequence, the possibility of the analyst missing (or misreading) vital information is high.