Jürgen Krauss – författare

In Recombinant Antibodies for Cancer Therapy: Methods and Protocols, Martin Welschoff and Jurgen Krauss present a collection of carefully selected protocols for the design, construction, and characterization of novel anticancer therapeutics based on recombinant antibody technology. These readily reproducible methods include coverage of hybridoma-derived recombinant antibodies, recombinant antibody fragments from phagemid-displayed antibody repertoires, antibody fragments with additional properties, and large-scale production of recombinant antibodies for clinical applications. Concise review articles also survey the current status of recombinant antibodies in cancer therapy, as well as the generation of antibody molecules through antibody engineering.

Since the advent of hybridoma technology more than two decades ago, numerous antibodies have entered the clinical setting as potent therapeutic agents. Their repeated application in humans, however, is limited by the development of human antimouse antibodies (HAMA) in the recipient, leading to allergic re- tions against the foreign murine protein and rapid neutralization. To circumvent these limitations many new antibodies have recently been tailored through recombinant antibody technology. The initial clinical data show encouraging results, thus demonstrating the potential of these new therapeutic agents. The purpose of Recombinant Antibodies for Cancer Therapy is to present a collection of detailed protocols in recombinant antibody technology. It is pri- rily addressed to scientists working on recombinant antibodies as well as cli- cians involved with antibody-based therapies. As with other volumes of this series, we placed the main focus on providing detailed protocols describing procedures step-by-step. Moreover, each protocol supplies a troubleshooting guide containing detailed information on possible problems and hints for pot- tial solutions. Antibody technology is a subject of constant and rapid change. This volume, therefore, does not attempt to cover all possible current experimental approaches in the field. Rather, we present carefully selected protocols, written by competent authors who have successfully verified the particular method described. Given our own professional backgrounds and interest in oncology, we chose to conc- trate chiefly on therapeutic agents for cancer patients.

Since the advent of hybridoma technology more than two decades ago, numerous antibodies have entered the clinical setting as potent therapeutic agents. Their repeated application in humans, however, is limited by the development of human antimouse antibodies (HAMA) in the recipient, leading to allergic re- tions against the foreign murine protein and rapid neutralization. To circumvent these limitations many new antibodies have recently been tailored through recombinant antibody technology. The initial clinical data show encouraging results, thus demonstrating the potential of these new therapeutic agents. The purpose of Recombinant Antibodies for Cancer Therapy is to present a collection of detailed protocols in recombinant antibody technology. It is pri- rily addressed to scientists working on recombinant antibodies as well as cli- cians involved with antibody-based therapies. As with other volumes of this series, we placed the main focus on providing detailed protocols describing procedures step-by-step. Moreover, each protocol supplies a troubleshooting guide containing detailed information on possible problems and hints for pot- tial solutions. Antibody technology is a subject of constant and rapid change. This volume, therefore, does not attempt to cover all possible current experimental approaches in the field. Rather, we present carefully selected protocols, written by competent authors who have successfully verified the particular method described. Given our own professional backgrounds and interest in oncology, we chose to conc- trate chiefly on therapeutic agents for cancer patients.

Bring the magic of a German Christmas into your home with this foolproof collection of delicious recipes.In a follow-up to his bestselling first book, German Baking, Jürgen Krauss brings festive cheer to his delightful German bakes. From a rich and fruity stollen, to delicately spiced lebkuchen, festive marzipan treats, and of course the iconic gingerbread house, these are traditional treats made easy and achievable, and the perfect way to bring some extra joy into your Christmas baking.The book will include 53 brand new recipes, 5 new versions of festive favourites from German Baking, and 7 basic recipes - for luxury marzipan, hazelnut paste etc - that can be used to upgrade any bake with a German twist. This is the ultimate guide to festive baking, with a cake, tart, biscuit, bread or savoury snack for everyone looking for something to make their Christmas extra special.

The first book from the much-loved Great British Bake Off semi-finalist.Jürgen Krauss's gentle charm, ambitious flavours and scientific know-how captured audiences' hearts on The Great British Bake Off, his semi-finals departure triggering unprecedented complaints from dismayed viewers. Drawing on the flavours and techniques of his childhood home in the Black Forest, this fool-proof collection of recipes provides delicious inspiration for any time of day and any occasion. From sweet and savoury classics such as Flammkuchen, cinnamon and raisin braid, Streusel, marble cake, and Sacher Torte, to festive bakes such as Lebkuchen, marzipan swirl biscuits, Stollen and Easter braid, they are the perfect way to celebrate German baking at home.