Epigenetic Regulation in Overcoming Chemoresistance, Volume 19, explains how epigenetic agents can enhance the chemotherapy sensitivity of diverse types of cancers. The book provides a comprehensive delineation and the recent development of the scientific studies on the epigenetic regulation in enhancing chemo-sensitivity. In addition, it discusses several topics such as DNA methyltransferase inhibitors (DNMTi), Histone deacetylases inhibitors (HDACi), Histone lysine demethylases inhibitors (HDMi), Histone lysine methyltransferases inhibitors (HMTi) and drugs regulating the microRNA, long non-coding RNA (lncRNA) or RNA methylation. Finally, recent and future developments of the field of epigenetic regulation are explored.

This is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested in learning about epigenetic regulation methods to reverse chemo-resistance in cancers.

Proactive Human-Robot Collaboration Toward Human-Centric Smart Manufacturing is driven by an appreciation of manufacturing scenarios where human and robotic agents can understand each other’s actions and conduct mutual-cognitive, predictable, and self-organizing teamwork. Modern factories’ smart manufacturing transformation and the evolution of relationships between humans and robots in manufacturing tasks set the scene for a discussion on the technical fundamentals of state-of-the-art proactive human-robot collaboration; these are further elaborated into the three main steps (i.e., mutual-cognitive and empathic coworking; predictable spatio-temporal collaboration; self-organizing multiagent teamwork) to achieve an advanced form of symbiotic HRC with high-level, dynamic-reasoning teamwork skills. The authors then present a deployment roadmap and several case studies, providing step-by-step guidance for real-world application of these ground-breaking methods which crucially contribute to the maturing of human-centric, sustainable, and resilient production systems. The volume proves to be an invaluable resource that supports understanding and learning for users ranging from upper undergraduate/graduate students and academic researchers to engineering professionals in a variety of industry contexts.

With the increasing complexity and dynamism in today’s product design and manufacturing, more optimal, robust and practical approaches and systems are needed to support product design and manufacturing activities. Multi-objective Evolutionary Optimisation for Product Design and Manufacturing presents a focused collection of quality chapters on state-of-the-art research efforts in multi-objective evolutionary optimisation, as well as their practical applications to integrated product design and manufacturing.

Multi-objective Evolutionary Optimisation for Product Design and Manufacturing consists of two major sections. The first presents a broad-based review of the key areas of research in multi-objective evolutionary optimisation. The second gives in-depth treatments of selected methodologies and systems in intelligent design and integrated manufacturing.

Recent developments and innovations in multi-objective evolutionary optimisation make Multi-objective Evolutionary Optimisation for Product Design and Manufacturing a useful text for a broad readership, from academic researchers to practicing engineers.

With the increasing complexity and dynamism in today’s machine design and development, more precise, robust and practical approaches and systems are needed to support machine design. Existing design methods treat the targeted machine as stationery. Analysis and simulation are mostly performed at the component level. Although there are some computer-aided engineering tools capable of motion analysis and vibration simulation etc., the machine itself is in the dry-run state. For effective machine design, understanding its thermal behaviours is crucial in achieving the desired performance in real situation.

Dynamic Thermal Analysis of Machines in Running State presents a set of innovative solutions to dynamic thermal analysis of machines when they are put under actual working conditions. The objective is to better understand the thermal behaviours of a machine in real situation while at the design stage. The book has two major sections, with the first section presenting a broad-based review of the key areas of research in dynamic thermal analysis and simulation, and the second section presents an in-depth treatment of relevant methodology and algorithms, leading to better understanding of a machine in real situation.

The book is a collection of novel ideas, taking into account the need for presenting intellectual challenges while appealing to a broad readership, including academic researchers, practicing engineers and managers, and graduate students. Given the essential role of modern machines in factory automation and quality assurance, a book dedicated to the topic of dynamic thermal analysis, and its practical applications to machine design would be beneficial to readers of all design and manufacturing sectors, from machine design to automotive engineering, in better understanding the present challenges andsolutions, as well as future research directions in this important area.

Manufacturing systems and processes are becoming more complex, so more rational decision-making in process control is a necessity. Better information gathering and analysis techniques are needed and condition  monitoring is seen as a framework that will enable these improvements.

Condition Monitoring and Control for Intelligent Manufacturing brings together the world’s authorities on condition monitoring to provide a broad treatment of the subject accessible to researchers and practitioners in manufacturing industry.

The book presents a review of the key areas of research in machine condition monitoring and control, before focusing on an in-depth treatment of each important technique, from multi-domain signal processing for defect diagnosis to web-based information delivery for real-time control.

Researchers in manufacturing and control engineering, as well as practising engineers in industries from automotive to packaging manufacturing will find this book valuable.

Collaborative design has attracted much attention in the research community in recent years. With increasingly decentralized manufacturing systems and processes, more collaborative approaches and systems are needed to support distributed manufacturing operations. "Collaborative Design and Planning for Digital Manufacturing" presents a focused collection of quality chapters on the state-of-the-art research efforts in the area of collaborative design and planning, as well as their practical applications towards digital manufacturing.

"Collaborative Design and Planning for Digital Manufacturing" provides both a broad-based review of the key areas of research in digital manufacturing, and an in-depth treatment of particular methodologies and systems, from collaborative design to distributed planning, monitoring and control. Recent development and innovations in this area provide a pool of focused research efforts, relevant to a wide readership from academic researchers to practicing engineers.

Epigenetic Regulation in Overcoming Chemoresistance, Volume 19, explains how epigenetic agents can enhance the chemotherapy sensitivity of diverse types of cancers. The book provides a comprehensive delineation and the recent development of the scientific studies on the epigenetic regulation in enhancing chemo-sensitivity. In addition, it discusses several topics such as DNA methyltransferase inhibitors (DNMTi), Histone deacetylases inhibitors (HDACi), Histone lysine demethylases inhibitors (HDMi), Histone lysine methyltransferases inhibitors (HMTi) and drugs regulating the microRNA, long non-coding RNA (lncRNA) or RNA methylation. Finally, recent and future developments of the field of epigenetic regulation are explored.

This is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested in learning about epigenetic regulation methods to reverse chemo-resistance in cancers.

Proactive Human-Robot Collaboration Toward Human-Centric Smart Manufacturing is driven by an appreciation of manufacturing scenarios where human and robotic agents can understand each other’s actions and conduct mutual-cognitive, predictable, and self-organizing teamwork. Modern factories’ smart manufacturing transformation and the evolution of relationships between humans and robots in manufacturing tasks set the scene for a discussion on the technical fundamentals of state-of-the-art proactive human-robot collaboration; these are further elaborated into the three main steps (i.e., mutual-cognitive and empathic coworking; predictable spatio-temporal collaboration; self-organizing multiagent teamwork) to achieve an advanced form of symbiotic HRC with high-level, dynamic-reasoning teamwork skills. The authors then present a deployment roadmap and several case studies, providing step-by-step guidance for real-world application of these ground-breaking methods which crucially contribute to the maturing of human-centric, sustainable, and resilient production systems. The volume proves to be an invaluable resource that supports understanding and learning for users ranging from upper undergraduate/graduate students and academic researchers to engineering professionals in a variety of industry contexts.

With the increasing complexity and dynamism in today’s product design and manufacturing, more optimal, robust and practical approaches and systems are needed to support product design and manufacturing activities. Multi-objective Evolutionary Optimisation for Product Design and Manufacturing presents a focused collection of quality chapters on state-of-the-art research efforts in multi-objective evolutionary optimisation, as well as their practical applications to integrated product design and manufacturing.

Multi-objective Evolutionary Optimisation for Product Design and Manufacturing consists of two major sections. The first presents a broad-based review of the key areas of research in multi-objective evolutionary optimisation. The second gives in-depth treatments of selected methodologies and systems in intelligent design and integrated manufacturing.

Recent developments and innovations in multi-objective evolutionary optimisation make Multi-objective Evolutionary Optimisation for Product Design and Manufacturing a useful text for a broad readership, from academic researchers to practicing engineers.

With the increasing complexity and dynamism in today’s machine design and development, more precise, robust and practical approaches and systems are needed to support machine design. Existing design methods treat the targeted machine as stationery. Analysis and simulation are mostly performed at the component level. Although there are some computer-aided engineering tools capable of motion analysis and vibration simulation etc., the machine itself is in the dry-run state. For effective machine design, understanding its thermal behaviours is crucial in achieving the desired performance in real situation.

Dynamic Thermal Analysis of Machines in Running State presents a set of innovative solutions to dynamic thermal analysis of machines when they are put under actual working conditions. The objective is to better understand the thermal behaviours of a machine in real situation while at the design stage. The book has two major sections, with the first section presenting a broad-based review of the key areas of research in dynamic thermal analysis and simulation, and the second section presents an in-depth treatment of relevant methodology and algorithms, leading to better understanding of a machine in real situation.

The book is a collection of novel ideas, taking into account the need for presenting intellectual challenges while appealing to a broad readership, including academic researchers, practicing engineers and managers, and graduate students. Given the essential role of modern machines in factory automation and quality assurance, a book dedicated to the topic of dynamic thermal analysis, and its practical applications to machine design would be beneficial to readers of all design and manufacturing sectors, from machine design to automotive engineering, in better understanding the present challenges andsolutions, as well as future research directions in this important area.

Manufacturing systems and processes are becoming more complex, so more rational decision-making in process control is a necessity. Better information gathering and analysis techniques are needed and condition  monitoring is seen as a framework that will enable these improvements.

Condition Monitoring and Control for Intelligent Manufacturing brings together the world’s authorities on condition monitoring to provide a broad treatment of the subject accessible to researchers and practitioners in manufacturing industry.

The book presents a review of the key areas of research in machine condition monitoring and control, before focusing on an in-depth treatment of each important technique, from multi-domain signal processing for defect diagnosis to web-based information delivery for real-time control.

Researchers in manufacturing and control engineering, as well as practising engineers in industries from automotive to packaging manufacturing will find this book valuable.

Collaborative design has attracted much attention in the research community in recent years. With increasingly decentralized manufacturing systems and processes, more collaborative approaches and systems are needed to support distributed manufacturing operations. "Collaborative Design and Planning for Digital Manufacturing" presents a focused collection of quality chapters on the state-of-the-art research efforts in the area of collaborative design and planning, as well as their practical applications towards digital manufacturing.

"Collaborative Design and Planning for Digital Manufacturing" provides both a broad-based review of the key areas of research in digital manufacturing, and an in-depth treatment of particular methodologies and systems, from collaborative design to distributed planning, monitoring and control. Recent development and innovations in this area provide a pool of focused research efforts, relevant to a wide readership from academic researchers to practicing engineers.